Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression
TLDR
Preliminary data from patients with inflammatory disorders, as well as medically healthy depressed patients, suggest that inhibiting proinflammatory cytokines or their signaling pathways may improve depressed mood and increase treatment response to conventional antidepressant medication.About:
This article is published in Biological Psychiatry.The article was published on 2009-05-01 and is currently open access. It has received 3084 citations till now. The article focuses on the topics: Proinflammatory cytokine & Neurotransmitter metabolism.read more
Citations
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Inflammatory responses and inflammation-associated diseases in organs
Linlin Chen,Huidan Deng,Hengmin Cui,Jing Fang,Zhicai Zuo,Junliang Deng,Yinglun Li,Xun Wang,Ling Zhao +8 more
TL;DR: Inflammation is a biological response of the immune system that can be triggered by a variety of factors, including pathogens, damaged cells and toxic compounds, potentially leading to tissue damage or disease.
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The role of inflammation in depression: from evolutionary imperative to modern treatment target
TL;DR: Current understanding of the mechanisms by which the innate and adaptive immune systems interact with neurotransmitters and neurocircuits to influence the risk for depression are detailed.
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Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
Luigi Ferrucci,Elisa Fabbri +1 more
TL;DR: Whether therapies to modulate inflammageing can reduce the age-related decline in health is discussed, and the hypothesis that inflammation affects CVD, multimorbidity, and frailty is supported by mechanistic studies but requires confirmation in humans.
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From Stress to Inflammation and Major Depressive Disorder: A Social Signal Transduction Theory of Depression
TL;DR: A biologically plausible, multilevel theory is proposed that describes neural, physiologic, molecular, and genomic mechanisms that link experiences of social-environmental stress with internal biological processes that drive depression pathogenesis and may shed light on several important questions including how depression develops, why it frequently recurs, and why it is strongly predicted by early life stress.
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A Randomized Controlled Trial of the Tumor Necrosis Factor Antagonist Infliximab for Treatment-Resistant Depression The Role of Baseline Inflammatory Biomarkers
Charles L. Raison,Robin E. Rutherford,Bobbi J. Woolwine,Chen Shuo,Pamela J. Schettler,Daniel Drake,Ebrahim Haroon,Andrew H. Miller +7 more
TL;DR: This proof-of-concept study suggests that TNF antagonism does not have generalized efficacy in treatment-resistant depression but may improve depressive symptoms in patients with high baseline inflammatory biomarkers.
References
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From inflammation to sickness and depression: when the immune system subjugates the brain
TL;DR: In response to a peripheral infection, innate immune cells produce pro-inflammatory cytokines that act on the brain to cause sickness behaviour, which can lead to an exacerbation of sickness and the development of symptoms of depression in vulnerable individuals.
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Mammalian MAP kinase signalling cascades
Lufen Chang,Michael Karin +1 more
TL;DR: Recent studies have begun to shed light on the physiological functions of MAPK cascades in the control of gene expression, cell proliferation and programmed cell death.
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Anterior cingulate cortex, error detection, and the online monitoring of performance
Cameron S. Carter,Cameron S. Carter,Todd S. Braver,Todd S. Braver,M Deanna,M Deanna,Matthew Botvinick,Matthew Botvinick,Douglas C. Noll,Douglas C. Noll,Jonathan D. Cohen,Jonathan D. Cohen +11 more
TL;DR: Results confirm that this region shows activity during erroneous responses, but activity was also observed in the same region during correct responses under conditions of increased response competition, which suggests that the ACC detects conditions under which errors are likely to occur rather than errors themselves.
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Depression, chronic diseases, and decrements in health: results from the World Health Surveys
TL;DR: Depression produces the greatest decrement in health compared with the chronic diseases angina, arthritis, asthma, and diabetes, and the urgency of addressing depression as a public-health priority is indicated to improve the overall health of populations.