Vertical nanowire electrode arrays as a scalable platform for intracellular interfacing to neuronal circuits
Jacob T. Robinson,Marsela Jorgolli,Alex K. Shalek,Myung-Han Yoon,Rona S. Gertner,Hongkun Park +5 more
Reads0
Chats0
TLDR
It is shown that the scalability of this platform, combined with its compatibility with silicon nanofabrication techniques, provides a clear path towards simultaneous, high-fidelity interfacing with hundreds of individual neurons.Abstract:
Arrays of vertical silicon nanowires can record and stimulate neuronal activity from within mammalian nerve cells, and can also map multiple individual synaptic connections between these cells.read more
Citations
More filters
Journal ArticleDOI
Pursuing prosthetic electronic skin.
Alex Chortos,Jia Liu,Zhenan Bao +2 more
TL;DR: This Review will cover materials and devices designed for mimicking the skin's ability to sense and generate biomimetic signals.
Journal ArticleDOI
Multi-electrode array technologies for neuroscience and cardiology
Micha E. Spira,Aviad Hai +1 more
TL;DR: This Review describes the novel approaches, identifying their strengths and limitations from the point of view of the end users--with the intention to help steer the bioengineering efforts towards the needs of brain-circuit research.
Journal ArticleDOI
25th Anniversary Article: Semiconductor Nanowires – Synthesis, Characterization, and Applications
Neil P. Dasgupta,Jianwei Sun,Jianwei Sun,Chong Liu,Chong Liu,Sarah Brittman,Sarah Brittman,Sean C. Andrews,Sean C. Andrews,Jongwoo Lim,Jongwoo Lim,Hanwei Gao,Hanwei Gao,Ruoxue Yan,Ruoxue Yan,Peidong Yang +15 more
TL;DR: A detailed explanation of the unique properties associated with the one-dimensional nanowire geometry will be presented, and the benefits of these properties for the various applications will be highlighted.
Journal ArticleDOI
Degradability and Clearance of Silicon, Organosilica, Silsesquioxane, Silica Mixed Oxide, and Mesoporous Silica Nanoparticles.
TL;DR: The degradability and clearance timelines of various siliceous nanomaterials are compared and it is highlighted that researchers can select a specific nanommaterial in this large family according to the targeted applications and the required clearance kinetics.
Journal ArticleDOI
A Review of Organic and Inorganic Biomaterials for Neural Interfaces
TL;DR: An overview of state-of-the-art microelectrode technologies provided, with focus on the material properties of these microdevices for the development of long-lasting functional neural interfaces is provided.
References
More filters
Journal ArticleDOI
Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics
Dae-Hyeong Kim,Jonathan Viventi,Jason J. Amsden,Jianliang Xiao,Leif Vigeland,Yun-Soung Kim,Justin A. Blanco,Bruce Panilaitis,Eric S. Frechette,Diego Contreras,David L. Kaplan,Fiorenzo G. Omenetto,Yonggang Huang,Keh-Chih Hwang,Mitchell R. Zakin,Brian Litt,John A. Rogers +16 more
TL;DR: A material strategy for a type of bio-interfaced system that relies on ultrathin electronics supported by bioresorbable substrates of silk fibroin that provides new capabilities for implantable and surgical devices is described.
Journal ArticleDOI
Network anatomy and in vivo physiology of visual cortical neurons
Davi D. Bock,Wei-Chung Allen Lee,Aaron M. Kerlin,Mark L. Andermann,Greg Hood,Arthur W. Wetzel,Sergey Yurgenson,Edward R. Soucy,Hyon Suk Kim,R. Clay Reid +9 more
TL;DR: This work used two-photon calcium imaging to characterize a functional property—the preferred stimulus orientation—of a group of neurons in the mouse primary visual cortex and large-scale electron microscopy of serial thin sections was used to trace a portion of these neurons’ local network.
Journal ArticleDOI
Detection, Stimulation, and Inhibition of Neuronal Signals with High-Density Nanowire Transistor Arrays
Fernando Patolsky,Brian P. Timko,Guihua Yu,Ying Fang,Andrew B. Greytak,Gengfeng Zheng,Charles M. Lieber +6 more
TL;DR: Electrical properties of hybrid structures consisting of arrays of nanowire field-effect transistors integrated with the individual axons and dendrites of live mammalian neurons, where each nanoscale junction can be used for spatially resolved, highly sensitive detection, stimulation, and/or inhibition of neuronal signal propagation are reported.
Journal ArticleDOI
Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures.
Feng Zhang,Viviana Gradinaru,Antoine Roger Adamantidis,Remy Durand,Raag D. Airan,Luis de Lecea,Karl Deisseroth +6 more
TL;DR: In this paper, the authors collected in detail the strategies for delivering microbial opsin genes to deep mammalian brain structures in vivo, along with protocols for integrating the resulting optical control with compatible readouts (electrophysiological, optical and behavioral).
Journal ArticleDOI
Three-Dimensional, Flexible Nanoscale Field-Effect Transistors as Localized Bioprobes
TL;DR: In this article, a nanoscale field effect transistor (nanoFET) is integrated at the tip of an acute-angle kinked silicon nanowire, where the arms of the nanostructure are made by the arms and multilayer interconnects allow three-dimensional (3D) probe presentation.