Journal ArticleDOI
Visceral pain: a review of experimental studies.
Timothy J. Ness,G.F. Gebhart +1 more
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TLDR
This paper proposes a definition of an adequate noxious visceral stimulus and speculate on spinal mechanisms of visceral pain, and reviews clinical and basic science research reports on visceral pain.Abstract:
This paper reviews clinical and basic science research reports and is directed toward an understanding of visceral pain, with emphasis on studies related to spinal processing. Four main types of visceral stimuli have been employed in experimental studies of visceral nociception: (1) electrical, (2) mechanical, (3) ischemic, and (4) chemical. Studies of visceral pain are discussed in relation to the use and 'adequacy' of these stimuli and the responses produced (e.g., behavioral, pseudoaffective, neuronal, etc.). We propose a definition of an adequate noxious visceral stimulus and speculate on spinal mechanisms of visceral pain.read more
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Animal Models of Nociception
TL;DR: It is concluded that although the neural basis of the most used tests is poorly understood, their use will be more profitable if pain is considered within, rather than apart from, the body's homeostatic mechanisms.
Journal ArticleDOI
The induction of pain: an integrative review
TL;DR: A global account of mechanisms involved in the induction of pain is provided, including neuronal pathways for the transmission of nociceptive information from peripheral nerve terminals to the dorsal horn, and therefrom to higher centres.
Journal ArticleDOI
The Vanilloid Receptor: A Molecular Gateway to the Pain Pathway
Michael J. Caterina,David Julius +1 more
TL;DR: The analysis of vanilloid receptor gene knockout mice confirms the involvement of this channel in pain sensation, as well as in hypersensitivity to noxious stimuli following tissue injury, and demonstrates the existence of redundant mechanisms for the sensation of heat-evoked pain.
Journal ArticleDOI
Models and Mechanisms of Hyperalgesia and Allodynia
TL;DR: This review focuses on highly topical spinal mechanisms of hyperalgesia and allodynia including intrinsic and synaptic plasticity, the modulation of inhibitory control, and neuroimmune interactions.
Journal ArticleDOI
Basic and clinical aspects of visceral hyperalgesia
Emeran A. Mayer,G.F. Gebhart +1 more
TL;DR: A model is proposed by which abdominal pain from chronic inflammatory conditions of the gut and functional bowel disorders such as noncardiac chest pain, nonulcer dyspepsia, and irritable bowel syndrome could develop by multiple mechanisms either alone or in combination.
References
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Book
The Integrative Action of the Nervous System
TL;DR: In this article, the Integrative Action of the Nervous System [1906] Charles S. Sherrington, W.B. Hadden, and W.A. Baly have been discussed.
Journal ArticleDOI
Pain from distension of the pelvic colon by inflating a balloon in the irritable colon syndrome
TL;DR: Colonic hyperalgesia of this kind, possibly a random occurrence, may be an important contributory factor in the aetiology of the irritable colon syndrome.
Journal ArticleDOI
Release of prostaglandins E and F in an algogenic reaction and its inhibition.
TL;DR: An examination of cells collected by washing the peritoneum revealed a large decrease between 15 and 30 min after injection of the irritant, which suggested that the prostaglandins could be produced by neutrophil polynuclear cells but also by destruction of macrophages.
Journal ArticleDOI
Evidence for a viscerotopic sensory representation in the cortex and thalamus in the rat
TL;DR: The ascending pathway for visceral sensory information appears to be viscerotopically organized at all levels of the neuraxis, including the insular cortex.
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Colorectal distension as a noxious visceral stimulus: physiologic and pharmacologic characterization of pseudaffective reflexes in the rat
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