Journal ArticleDOI
Visualization of neurokinin-3 receptor sites in rat brain using the highly selective ligand [3H]senktide
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TLDR
Autoradiographic data show that [3H]senktide binding sites are concentrated in mid-cortical layers, supraoptic nucleus, zona incerta, basolateral nucleus of the amygdala and interpeduncular nucleus, and much lower densities of binding are seen in most other areas such as the caudate-putamen and cerebellum.About:
This article is published in Brain Research.The article was published on 1990-01-01. It has received 110 citations till now. The article focuses on the topics: Ligand (biochemistry) & Eledoisin.read more
Citations
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Neurotransmitter regulation of dopamine neurons in the ventral tegmental area.
TL;DR: Understanding the dynamic range of a transmitter's action and how this couples in concert with other transmitters to modulate dopamine neurons in the VTA is essential to defining the role of dopamine cells in the etiology and maintenance of neuropsychiatric disorders.
Journal ArticleDOI
Synaptic Control of Motoneuronal Excitability
TL;DR: A background description of motoneurons: their development, anatomical organization, and membrane properties, both passive and active, and a description of the major transmitter systems that affect mot oneuronal excitability, focusing on synaptic and cellular properties.
Journal ArticleDOI
Diversity in mammalian tachykinin peptidergic neurons: multiple peptides, receptors, and regulatory mechanisms.
TL;DR: Analysis of the functional significance of multiple tachykinin peptide systems, receptor‐second messenger coupling mechanisms, and developmental and regulatory mechanisms underlying peptide mRNA and receptor expression represent areas of current and future investigation.
Journal ArticleDOI
Tachykinin receptor types: Classification and membrane signalling mechanisms
Steven Guard,Stephen P. Watson +1 more
TL;DR: The purpose of this article is to review recent developments in the pharmacology of each receptor with emphasis on the NK(3) type and the need to use selective agonists and antagonists to identify each receptor type is stressed.
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Tachykinins: receptor to effector.
Aamir M Khawaja,Duncan F. Rogers +1 more
TL;DR: With the development of potent, selective non-peptide antagonists, there could be potential benefits in the treatment of a variety of clinical conditions, including chronic pain, Parkinson’s disease, Alzheimer's disease, depression, rheumatoid arthritis, irritable bowel syndrome and asthma.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
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The tachykinin peptide family
TL;DR: An update on the current body of knowledge regarding tachykinin occurrence and distribution in the animal kingdom, from the lowest invertebrates to man, and the physiological and pharmacological actions of tachyKinins outlining the pregnant importance of this large peptide family is provided.
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Pharmacological receptors for substance P and neurokinins.
TL;DR: A neurokinin receptor classification is attempted using the neurokinins and their fragments to determine the order of potency of agonists and some potent compounds have been identified that could provide selective receptor ligands.
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Autoradiographic localization and characterization of tachykinin receptor binding sites in the rat brain and peripheral tissues
TL;DR: The present classification of tachykinin receptors places a lower limit on the number of mammalian tachy Kinin receptor types and provides a functional/morphological framework for exploring the diverse actions of tachkinin peptides in both the CNS and peripheral tissues.
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Highly selective agonists for substance P receptor subtypes.
TL;DR: The action of selective SP‐N agonists in the guinea pig ileum is antagonized by opioid peptides, suggesting a functional counteraction between opiate andSP‐N receptors, indicating that the tachykinin receptors are distinct entities which may mediate different physiological functions.