Open AccessJournal Article
Vital signs: carbapenem-resistant Enterobacteriaceae.
Jesse T. Jacob,Eili Y. Klein,Ramanan Laxminarayan,Zintars G. Beldavs,Ruth Lynfield,Alexander J. Kallen,Philip Ricks,Jonathan R. Edwards,Arjun Srinivasan,Scott K. Fridkin,J. Kamile Rasheed,David Lonsway,Sandie Bulens,Rosa Herrera,L. Clifford McDonald,Jean B. Patel,Brandi Limbago,Michael Bell,Denise M. Cardo +18 more
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TLDR
Carbapenem resistance among common Enterobacteriaceae has increased over the past decade; most CRE are associated with health-care exposures; Implications for Public Health Interventions exist that could slow the dissemination of CRE.Abstract:
Background
Enterobacteriaceae are a family of bacteria that commonly cause infections in health-care settings as well as in the community. Among Enterobacteriaceae, resistance to broad-spectrum carbapenem antimicrobials has been uncommon. Over the past decade, however, carbapenem-resistant Enterobacteriaceae (CRE) have been recognized in health-care settings as a cause of difficult-to-treat infections associated with high mortality.read more
Citations
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Antibiotic resistance—the need for global solutions
Ramanan Laxminarayan,Ramanan Laxminarayan,Ramanan Laxminarayan,Adriano Duse,Chand Wattal,Anita K. M. Zaidi,Heiman F. L. Wertheim,Nithima Sumpradit,Erika Vlieghe,Gabriel Levy Hara,Ian M. Gould,Herman Goossens,Christina Greko,Anthony D. So,Maryam Bigdeli,Goeran Tomson,Will Woodhouse,Eva Ombaka,Arturo Quizhpe Peralta,Farah Naz Qamar,Fatima Mir,Sam Kariuki,Zulfigar A. Bhutta,Anthony R.M. Coates,Richard Bergstrom,Gerard D. Wright,Eric D. Brown,Otto Cars +27 more
TL;DR: The global situation of antibiotic resistance, its major causes and consequences, and key areas in which action is urgently needed are described and identified.
Journal ArticleDOI
Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society
Andre C. Kalil,Mark L. Metersky,Michael Klompas,John Muscedere,Daniel A. Sweeney,Lucy B. Palmer,Lena M. Napolitano,Naomi P. O'Grady,John G. Bartlett,Jordi Carratalà,Ali A. El Solh,Santiago Ewig,Paul D. Fey,Thomas M. File,Marcos I. Restrepo,Jason A. Roberts,Jason A. Roberts,Grant W. Waterer,Peggy E. Cruse,Shandra L Knight,Jan Brozek +20 more
TL;DR: These guidelines are intended for use by healthcare professionals who care for patients at risk for hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP), including specialists in infectious diseases, pulmonary diseases, critical care, and surgeons, anesthesiologists, hospitalists, and any clinicians and healthcare providers caring for hospitalized patients with nosocomial pneumonia.
Journal ArticleDOI
Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases
L. Silvia Munoz-Price,L. Silvia Munoz-Price,Laurent Poirel,Robert A. Bonomo,Robert A. Bonomo,Mitchell J. Schwaber,George L. Daikos,Martin Cormican,Giuseppe Cornaglia,Javier Garau,Marek Gniadkowski,Mary K. Hayden,Karthikeyan Kumarasamy,David M. Livermore,David M. Livermore,Juan J. Maya,Patrice Nordmann,Jean B. Patel,David L. Paterson,Johann D. D. Pitout,Maria Virginia Villegas,Hui Wang,Neil Woodford,John P. Quinn +23 more
TL;DR: The epidemiology of Klebsiella pneumoniae carbapenemases across continents is summarized, issues around detection, present antibiotic options and those in development, treatment outcome and mortality, and infection control are discussed.
Journal ArticleDOI
Klebsiella pneumoniae: Going on the Offense with a Strong Defense
Michelle K. Paczosa,Joan Mecsas +1 more
TL;DR: Recent studies have identified additional K. pneumoniae virulence factors and led to more insights about factors important for the growth of this pathogen at a variety of tissue sites, but much work is left to be done in characterizing these newly discovered factors.
Journal ArticleDOI
The Epidemiology of Carbapenem-Resistant Enterobacteriaceae: The Impact and Evolution of a Global Menace.
TL;DR: The evolution of CRE is discussed, with a focus on the epidemiology of the CPE pandemic; risk factors for colonization and infection with the most common transmissible CPE worldwide, Klebsiella pneumoniae carbapenemase-producing K. pneumoniae are reviewed; and strategies used to halt the striking spread of these deadly pathogens are presented.
References
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Performance standards for antimicrobial susceptibility testing
TL;DR: The supplemental information presented in this document is intended for use with the antimicrobial susceptibility testing procedures published in the following Clinical and Laboratory Standards Institute (CLSI)–approved standards.
Book
Principles and Practice of Infectious Diseases
TL;DR: This updated and expanded edition now offers 297 chapters that cover the basic principles of diagnosis and management, major clinical syndromes, all important pathogenic microbes and the diseases they cause, plus a number of specialised topics useful to the practitioner.
Journal ArticleDOI
Antimicrobial-Resistant Pathogens Associated with Healthcare- Associated Infections: Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2009-2010
Dawn M. Sievert,Philip Ricks,Jonathan R. Edwards,Amy Schneider,Jean B. Patel,Arjun Srinivasan,Alex Kallen,Brandi Limbago,Scott K. Fridkin +8 more
TL;DR: The frequency of selected antimicrobial resistance patterns among pathogens causing device-associated and procedure-associated healthcare-associated infections reported by hospitals in the National Healthcare Safety Network (NHSN) is described.
Journal ArticleDOI
Novel Carbapenem-Hydrolyzing β-Lactamase, KPC-1, from a Carbapenem-Resistant Strain of Klebsiella pneumoniae
Hesna Yigit,Anne Marie Queenan,Gregory J. Anderson,Antonio Doménech-Sánchez,James W. Biddle,Christine D. Steward,Sebastián Albertí,Karen Bush,Fred C. Tenover +8 more
TL;DR: K. pneumoniae strain 1534 is mainly due to production of a novel Bush group 2f, class A, carbapenem-hydrolyzing β-lactamase, KPC-1, although alterations in porin expression may also play a role.
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