Journal ArticleDOI
Vitamin D3 insufficiency and colorectal cancer.
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TLDR
The current review addresses some of the key mechanisms that influence the biological actions of vitamin D and its metabolites and may aid in designing new uses for this hormone and its non-hypercalcemic derivatives in the treatment and/or prevention of CRC.Abstract:
Traditionally the main recognized function of vitamin D has been calcium and phosphate homeostasis. Nevertheless, recent evidences have highlighted the importance of vitamin D3 as a protective agent against various cancers. The association between CRC and vitamin D3 was first suggested in ecologic studies, but further was confirmed by observational studies in humans and experimental studies in both animal models and cellular lines. The protective role of vitamin D3 against cancer has been attributed to its influence of on cell proliferation, differentiation, apoptosis, DNA repair mechanisms, inflammation and immune function. In its active (calcitriol) form (1,25-dihydroxyvitamin D3[1α,25-(OH)2D3]) vitamin D3 and the nuclear vitamin D receptor (VDR) regulate hundreds of genes including those coding for proteins involved in cell differentiation and cell proliferation. The current review addresses some of the key mechanisms that influence the biological actions of vitamin D and its metabolites. The insights derived from these mechanisms may aid in designing new uses for this hormone and its non-hypercalcemic derivatives in the treatment and/or prevention of CRC.read more
Citations
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Minireview: vitamin D receptor: new assignments for an already busy receptor. - eScholarship
TL;DR: This minireview summarizes a proposed conformational ensemble model of the VDR that provides insight into how different ligand shapes of 1alpha,25(OH)2D3 acting through theVDR in different cellular locations can selectively mediate both genomic and RR.
OtherDOI
PTH and Vitamin D
TL;DR: PTH and Vitamin D are two major regulators of mineral metabolism and play critical roles in the maintenance of calcium and phosphate homeostasis as well as the development and maintenance of bone health.
Dissertation
Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors
Journal ArticleDOI
Vitamin D receptor agonists' anti-inflammatory properties.
TL;DR: Considering the selective anti‐inflammatory effects of VDR agonists compared to glucocorticoids, sparing microbicidal functions, the fear of hypercalcemia as their only frequent side effect becomes a questionable reason for the lack of clinical studies.
Journal ArticleDOI
Graphene quantum dot-gold hybrid nanoparticles integrated aptasensor for ultra-sensitive detection of vitamin D3 towards point-of-care application
TL;DR: A portable electrochemical aptasensor for the detection of vitamin D3 using graphene quantum dot-gold (GQD-Au) hybrid nanoparticles is reported, which has a linear range of 1–500 nM, limit of detection (LOD), and a response time of 0.90 Ω-nM−1 mm−2.
References
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Journal ArticleDOI
The basics of epithelial-mesenchymal transition
Raghu Kalluri,Robert A. Weinberg +1 more
TL;DR: Processes similar to the EMTs associated with embryo implantation, embryogenesis, and organ development are appropriated and subverted by chronically inflamed tissues and neoplasias and the identification of the signaling pathways that lead to activation of EMT programs during these disease processes is providing new insights into the plasticity of cellular phenotypes.
Book
Vitamin D
TL;DR: In what case do you like reading so much? What about the type of the vitamin d the calcium homeostatic steroid hormone book? The needs to read? Well, everybody has their own reason why should read some books as discussed by the authors.
Journal ArticleDOI
Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis
TL;DR: A coupling between physical adhesion and developmental signaling provides a mechanism to tightly integrate physical aspects of tissue morphogenesis with cell growth and differentiation, a coordination that is essential to achieve the intricate patterns of cells in tissues.
Journal ArticleDOI
AP-1 as a regulator of cell life and death
Eitan Shaulian,Michael Karin +1 more
TL;DR: Interestingly, the growth-promoting activity of c-Jun is mediated by repression of tumour suppressors, as well as upregulation of positive cell cycle regulators, whereas JunB has the converse effect.
Journal ArticleDOI
Vitamin D deficiency : a worldwide problem with health consequences
Michael F. Holick,Tai C. Chen +1 more
TL;DR: Vitamin D deficiency causes rickets in children and will precipitate and exacerbate osteopenia, osteoporosis, and fractures in adults, and foods that are fortified with vitamin D are often inadequate to satisfy either a child's or an adult's vitamin D requirement.