Weight Loss and Regain and Effects on Body Composition: The Health, Aging, and Body Composition Study
Jung Sun Lee,Marjolein Visser,Marjolein Visser,Frances A. Tylavsky,Stephen B. Kritchevsky,Ann V. Schwartz,Nadine R. Sahyoun,Tamara B. Harris,Anne B. Newman +8 more
TLDR
It is suggested that weight loss even with regain may contribute to a net loss of lean mass in older men but warrant further studies.Abstract:
Background. Older adults are less able to conserve lean mass relative to fat mass with weight change. A cycle of weight loss and regain in an older individual could accelerate sarcopenia. We examined whether older adults experiencing weight loss and regain would show a greater loss of lean mass during a weight-loss period than gain in lean mass during the weight-regain period, thus have overall a greater net loss of lean mass compared with those who maintained weight in the Health, Aging, and Body Composition Study. Methods. We compared the body composition change in 147 older weight changers (54% women, 38% black) with the gender- and race-matched weight-stable individuals over the weight-cycling period. A weight cycle was defi ned as weight loss of 3% or more with regain of within ± 3% of baseline weight for a period of 2 years. Results. Both men and women showed signifi cantly lower total body mass after the weight loss and regain. Proportionally, more lean mass was lost during the weight-loss period than was gained during the weight-regain period, especially in men. After weight regain, men showed only a slightly lower lean mass than the stable group, and this was not statistically signifi cant, although the failure to fully regain total weight explained most of the defi cit in lean mass after the weight cycle. Conclusion. These data suggest that weight loss even with regain may contribute to a net loss of lean mass in older men but warrant further studies.read more
Citations
More filters
Journal ArticleDOI
Bone Metabolism in Obesity and Weight Loss
Sue A. Shapses,Deeptha Sukumar +1 more
TL;DR: Future obesity and weight loss trials would benefit from assessment of key hormones, adipokine and gut peptides that regulate calcium absorption, and bone mineral density and quality by using sensitive techniques in high-risk populations.
Journal ArticleDOI
Physiologic Frailty As a Sign of Accelerated Aging Among Adult Survivors of Childhood Cancer: A Report From the St Jude Lifetime Cohort Study
Kirsten K. Ness,Kevin R. Krull,Kendra E. Jones,Daniel A. Mulrooney,Gregory T. Armstrong,Daniel M. Green,Wassim Chemaitilly,Webb A. Smith,Carmen L. Wilson,Charles A. Sklar,Kyla Shelton,Deo Kumar Srivastava,Sabeen Ali,Leslie L. Robison,Melissa M. Hudson +14 more
TL;DR: The prevalence of frailty among young adult CCS is similar to that among adults 65 years old and older, suggesting accelerated aging.
Journal ArticleDOI
Weight loss in obese adults 65years and older: a review of the controversy.
TL;DR: It is indicated that healthy weight loss in this age group can be achieved through lifestyle interventions of up to a one-year period, and most interventions reviewed reported a loss of lean body mass and bone mineral density with weight loss.
Journal ArticleDOI
Biological mechanisms that promote weight regain following weight loss in obese humans
TL;DR: Research is discussed on several factors that may contribute to weight regain following weight loss achieved through behavioral interventions, including adipose cellularity, endocrine function, energy metabolism, neural responsivity, and addiction-like neural mechanisms.
Journal ArticleDOI
Longitudinal changes in body composition associated with healthy ageing: men, aged 20-96 years.
TL;DR: BMI and percentage of body fat were sensitive in detecting the increase in fat mass that occurred with healthy ageing, but failed to identify the loss of fat-free mass that started at age 47 years.
References
More filters
Journal ArticleDOI
Weight Change in Old Age and its Association with Mortality
Anne B. Newman,David Yanez,Tamara B. Harris,Andrew S. Duxbury,Paul L. Enright,Linda P. Fried +5 more
TL;DR: The objective was to determine whether 5% weight gain or loss in 3 years was predictive of mortality in a large sample of older adults.
Journal ArticleDOI
The definition of weight maintenance
TL;DR: The authors recommend that long-term weight maintenance in adults be defined as a weight change of <3% of body weight.
Journal ArticleDOI
Validity of fan-beam dual-energy X-ray absorptiometry for measuring fat-free mass and leg muscle mass
TL;DR: The results of this study suggest that fan-beam DEXA offers considerable promise for the measurement of total body FFM and leg MM in elderly persons.
Journal ArticleDOI
Weight change and the conservation of lean mass in old age: the Health, Aging and Body Composition Study.
Anne B. Newman,Jung Sun Lee,Marjolein Visser,Bret H. Goodpaster,Stephen B. Kritchevsky,Frances A. Tylavsky,Michael C. Nevitt,Tamara B. Harris +7 more
TL;DR: Findings suggest that weight loss, even with regain, could accelerate sarcopenia in older adults, and a greater proportion of lean mass than of fat mass was conserved.
Journal ArticleDOI
QDR 4500A dual-energy X-ray absorptiometer underestimates fat mass in comparison with criterion methods in adults
Dale A. Schoeller,Frances A. Tylavsky,David J. Baer,William Cameron Chumlea,Carrie P. Earthman,Thomas Fuerst,Tamara B. Harris,Steven B. Heymsfield,Mary Horlick,Timothy G. Lohman,Henry C. Lukaski,John A. Shepherd,Roger M. Siervogel,Lori G. Borrud +13 more
TL;DR: It is recommended that the lean soft tissue mass estimate with the fan-beam QDR 4500A be reduced by 5% and that for fat mass be increased by that same mass.