Journal ArticleDOI
What is the optimal means of preparing the endometrium in frozen–thawed embryo transfer cycles? A systematic review and meta-analysis
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TLDR
All of the current methods of endometrial preparation appear to be equally successful in terms of ongoing pregnancy rate, however, in some comparisons predominantly retrospective studies were included leaving these comparisons subject to selection and publication bias.Abstract:
BACKGROUND Frozen-thawed embryo transfer (FET) enables surplus embryos derived from IVF or IVF-ICSI treatment to be stored and transferred at a later date. In recent years the number of FET cycles performed has increased due to transferring fewer embryos per transfer and improved laboratory techniques. Currently, there is little consensus on the most effective method of endometrium preparation prior to FET. METHODS Using both MEDLINE and EMBASE database a systematic review and meta-analysis of literature was performed. Case-series, case-control studies and articles in languages other than English, Dutch or Spanish were excluded. Those studies comparing clinical and ongoing pregnancy rates as well as live birth rates in (i) true natural cycle FET (NC-FET) versus modified NC-FET, (ii) NC-FET versus artificial cycle FET (AC-FET), (iii) AC-FET versus artificial with GnRH agonist cycle FET and (iv) NC-FET versus artificial with GnRH agonist cycle FET were included. Forest plots were constructed and relative risks or odds ratios were calculated. RESULTS A total of 43 publications were selected for critical appraisal and 20 articles were included in the final review. For all comparisons, no differences in the clinical pregnancy rate, ongoing pregnancy rate or live birth rate could be found. Based on information provided in the articles no conclusions could be drawn with regard to cancellation rates. CONCLUSIONS Based on the current literature it is not possible to identify one method of endometrium preparation in FET as being more effective than another. Therefore, all of the current methods of endometrial preparation appear to be equally successful in terms of ongoing pregnancy rate. However, in some comparisons predominantly retrospective studies were included leaving these comparisons subject to selection and publication bias. Also patients' preferences as well as cost-efficiency were not addressed in any of the included studies. Therefore, prospective randomized studies addressing these issues are needed.read more
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Journal ArticleDOI
Frozen embryo transfers in a natural cycle: how to do it right
TL;DR: In this paper , the authors present an endometrial receptivity in the FET cycle can be achieved through a hormonal replacement cycle or a natural cycle, and the preparation approach has important implications on the pregnancy itself.
Journal ArticleDOI
The relationship between serum oestrogen levels and clinical outcomes of hormone replacement therapy-frozen embryo transfer: a retrospective clinical study
Na Kong,Jingyu Liu,Chunxue Zhang,Yue-hua Jiang,Yingchun Zhu,Guijun Yang,Haixiang Sun,Chenyang Huang +7 more
TL;DR: Wang et al. as mentioned in this paper explored the relationship between serum oestrogen (E2) levels before endometrial transformation and pregnancy outcomes of HRT-FET cycles, which has been investigated for years without any consensus.
Journal ArticleDOI
Comparison of natural and artificial cycles in frozen-thawed embryo transfer: A retrospective analysis of 1696 cycles
Erhan Demirdag,Ismail Güler,M. F. Cevher Akdulum,Esin Şahin,Ayşe Duygu Tufan,Ahmet Erdem,Mehmet Erdem +6 more
TL;DR: Comparisons of pregnancy outcomes of natural cycles (NC) and artificial cycles (AC) in patients undergoing endometrial preparation for frozen-thawed embryo transfer (FET) showed no superiority was determined in NC or AC protocols in frozen- thawed cycles.
Journal ArticleDOI
Luteal phase support for natural cycle frozen embryo transfer: a meta-analysis.
TL;DR: In this paper, the effect of luteal phase support (LPS) on pregnancy outcome in natural cycle frozen embryo transfer (NC-FET) was evaluated using review manager 5.3.
References
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Journal ArticleDOI
Hormonal Dynamics at Midcycle: A Reevaluation*
TL;DR: The data provide a relatively precise picture of the hormonal changes preceding the onset of the gonadotropin surge and the temporal relationship between the multiphasic P4 rise and pituitary-ovarian function.
Journal ArticleDOI
Estrogen is a critical determinant that specifies the duration of the window of uterine receptivity for implantation
TL;DR: It is demonstrated here that levels of estrogen within a very narrow range determine the duration of the window of uterine receptivity, and it is suggested that careful regulation of estrogen levels is one of the important factors for improvement of female fertility in IVF/ET programs.
Journal ArticleDOI
Luteal phase support for assisted reproduction cycles
TL;DR: The relative effectiveness and safety of methods of luteal phase support provided to subfertile women undergoing assisted reproduction using progesterone, hCG or GnRH agonist supplementation in ART cycles was determined.
Journal ArticleDOI
Cycle regimens for frozen-thawed embryo transfer
TL;DR: There was no evidence of a difference in multiple pregnancy rates between women in natural cycles and those in HT FET cycle, and very low-quality evidence suggested that women innatural cycles (without HCG trigger) may have higher ongoing pregnancy rates.
Journal ArticleDOI
Relationship between endometrial thickness and embryo implantation, based on 1,294 cycles of in vitro fertilization with transfer of two blastocyst-stage embryos
TL;DR: Clinical pregnancy and live-birth or ongoing pregnancy rates increase significantly with increasing endometrial thickness, independent of the effects of patient age and embryo quality.
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