Journal ArticleDOI
What is the optimal means of preparing the endometrium in frozen–thawed embryo transfer cycles? A systematic review and meta-analysis
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TLDR
All of the current methods of endometrial preparation appear to be equally successful in terms of ongoing pregnancy rate, however, in some comparisons predominantly retrospective studies were included leaving these comparisons subject to selection and publication bias.Abstract:
BACKGROUND Frozen-thawed embryo transfer (FET) enables surplus embryos derived from IVF or IVF-ICSI treatment to be stored and transferred at a later date. In recent years the number of FET cycles performed has increased due to transferring fewer embryos per transfer and improved laboratory techniques. Currently, there is little consensus on the most effective method of endometrium preparation prior to FET. METHODS Using both MEDLINE and EMBASE database a systematic review and meta-analysis of literature was performed. Case-series, case-control studies and articles in languages other than English, Dutch or Spanish were excluded. Those studies comparing clinical and ongoing pregnancy rates as well as live birth rates in (i) true natural cycle FET (NC-FET) versus modified NC-FET, (ii) NC-FET versus artificial cycle FET (AC-FET), (iii) AC-FET versus artificial with GnRH agonist cycle FET and (iv) NC-FET versus artificial with GnRH agonist cycle FET were included. Forest plots were constructed and relative risks or odds ratios were calculated. RESULTS A total of 43 publications were selected for critical appraisal and 20 articles were included in the final review. For all comparisons, no differences in the clinical pregnancy rate, ongoing pregnancy rate or live birth rate could be found. Based on information provided in the articles no conclusions could be drawn with regard to cancellation rates. CONCLUSIONS Based on the current literature it is not possible to identify one method of endometrium preparation in FET as being more effective than another. Therefore, all of the current methods of endometrial preparation appear to be equally successful in terms of ongoing pregnancy rate. However, in some comparisons predominantly retrospective studies were included leaving these comparisons subject to selection and publication bias. Also patients' preferences as well as cost-efficiency were not addressed in any of the included studies. Therefore, prospective randomized studies addressing these issues are needed.read more
Citations
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Journal ArticleDOI
Fresh versus frozen embryo transfer: backing clinical decisions with scientific and clinical evidence
Jemma Evans,Natalie J. Hannan,Tracey A. Edgell,Beverley Vollenhoven,Peter Lutjen,Tiki Osianlis,Lois A. Salamonsen,Lois A. Salamonsen,Luk Rombauts +8 more
TL;DR: The literature demonstrates reduced endometrial receptivity in controlled ovarian stimulation cycles and supports the clinical observations that FET reduces the risk of ovarian hyperstimulation syndrome and improves outcomes for both the mother and baby.
Journal ArticleDOI
Cryopreservation of human embryos and its contribution to in vitro fertilization success rates
TL;DR: Interestingly, success rates after frozen-thawed embryo transfer are now nearing the success rates of fresh embryo transfer, which supports the hypothesis of so called freeze-all strategies in IVF, in which all embryos are frozen and no fresh transfer is conducted, to optimize success rates.
Journal ArticleDOI
Frozen embryo transfer: a review on the optimal endometrial preparation and timing.
Shari Mackens,Samuel Santos-Ribeiro,A. van de Vijver,Annalisa Racca,L. Van Landuyt,Herman Tournaye,Christophe Blockeel,Christophe Blockeel +7 more
TL;DR: A standardized timing strategy based on the current available evidence which could assist in the harmonization and comparability of clinic practice and future trials is proposed, with special attention to the timing of the embryo transfer.
Journal ArticleDOI
Clinical rationale for cryopreservation of entire embryo cohorts in lieu of fresh transfer.
TL;DR: There have been reports of greater implantation and pregnancy rates with FET than with fresh autologous embryo transfer, suggesting superior endometrial receptivity in the absence of ovarian stimulation.
Journal ArticleDOI
Forty years of IVF
Craig Niederberger,Antonio Pellicer,Jacques Cohen,David K. Gardner,Gianpiero D. Palermo,C. O'Neill,S. Chow,Zev Rosenwaks,Ana Cobo,Jason E. Swain,William B. Schoolcraft,René Frydman,L.A. Bishop,Davora Aharon,Catherine M. Gordon,Erika New,Alan H. DeCherney,Seang Lin Tan,Richard J. Paulson,James M. Goldfarb,Mats Brännström,Jacques Donnez,Sherman J. Silber,Marie-Madeleine Dolmans,Marie-Madeleine Dolmans,Joe Leigh Simpson,Alan H. Handyside,Santiago Munné,Cristina Eguizabal,Nuria Montserrat,Juan Carlos Izpisua Belmonte,Alan O Trounson,Carlos Simón,Togas Tulandi,Linda C. Giudice,Robert J. Norman,Aaron J. W. Hsueh,Yingpu Sun,Neri Laufer,Ronit Kochman,Talia Eldar-Geva,Bruno Lunenfeld,Diego Ezcurra,Thomas D'Hooghe,Thomas D'Hooghe,Thomas D'Hooghe,Bart C.J.M. Fauser,Basil C. Tarlatzis,David R. Meldrum,Robert F. Casper,Human M. Fatemi,Paul Devroey,Daniela Galliano,Matts Wikland,Mark Sigman,Richard A. Schoor,Marc Goldstein,Larry I. Lipshultz,Peter N. Schlegel,Alayman Hussein,Robert D. Oates,Robert E. Brannigan,Heather E. Ross,Guido Pennings,Susan C. Klock,Simon Brown,Andre Van Steirteghem,Robert W. Rebar,Robert W. Rebar,Andrew R. LaBarbera,Andrew R. LaBarbera,Andrew R. LaBarbera +71 more
TL;DR: This monograph, written by the pioneers of IVF and reproductive medicine, celebrates the history, achievements, and medical advancements made over the last 40 years in this rapidly growing field.
References
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Journal ArticleDOI
The Impact of Endometrial Preparation on Implantation following Cryopreserved-Thawed-Embryo Transfer
TL;DR: The specific method of endometrial preparation for CT-ET had no significant impact upon the implantation rate, and no statistically significant difference was found in implants per embryo transfer.
Journal ArticleDOI
Blastocyst frozen embryo transfer (FET): Comparison of outcome with replacement in natural or programmed/medicated cycle
Steven D. Spandorfer,Sozos J. Fasouliotis,C. Cimmino,M. Shpizner,Lucinda L. Veeck,Zev Rosenwaks +5 more
Journal ArticleDOI
Endocrine and biological factors influencing implantation of human embryos following cryopreservation
TL;DR: There was no difference in the estradiol/progesterone ratio among the three different protocols during the early luteal phase of the cycle, which may indicate that implantation of thawed embryos could be related to their developmental potential rather than to the endometrial environment.
Journal ArticleDOI
Artificial endometrial stimulation for frozen embryo replacement
TL;DR: In this article, the endometrium was prepared using a uniform protocol of exogenous E and P. This approach eliminated cycle cancellations caused by ovulatory dysfunction and gave complete cycle control.
Patent
Ultrasonic monitoring device
TL;DR: In this paper, an ultrasonic monitoring apparatus is provided for use by an operator in detecting ultrasonic vibrations and sound waves, which consists of a hand-held device with a sensor socket 36 that allows a variety of different types of sensors to be interchangeably installed in the hand held device.
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