Worldwide Trends in Incidence Rates for Oral Cavity and Oropharyngeal Cancers
Anil K. Chaturvedi,William F. Anderson,Joannie Lortet-Tieulent,Maria Paula Curado,Jacques Ferlay,Silvia Franceschi,Philip S. Rosenberg,Freddie Bray,Maura L. Gillison +8 more
TLDR
OPC incidence significantly increased during 1983 to 2002 predominantly in developed countries and at younger ages, underscore a potential role for HPV infection on increasing OPC incidence, particularly among men.Abstract:
Purpose Human papillomavirus (HPV) has been identified as the cause of the increasing oropharyngeal cancer (OPC) incidence in some countries. To investigate whether this represents a global phenomenon, we evaluated incidence trends for OPCs and oral cavity cancers (OCCs) in 23 countries across four continents. Methods We used data from the Cancer Incidence in Five Continents database Volumes VI to IX (years 1983 to 2002). Using age-period-cohort modeling, incidence trends for OPCs were compared with those of OCCs and lung cancers to delineate the potential role of HPV vis-a-vis smoking on incidence trends. Analyses were country specific and sex specific. Results OPC incidence significantly increased during 1983 to 2002 predominantly in economically developed countries. Among men, OPC incidence significantly increased in the United States, Australia, Canada, Japan, and Slovakia, despite nonsignificant or significantly decreasing incidence of OCCs. In contrast, among women, in all countries with increasing ...read more
Citations
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Variation in cancer risk among tissues can be explained by the number of stem cell divisions
TL;DR: It is shown that the lifetime risk of cancers of many different types is strongly correlated with the total number of divisions of the normal self-renewing cells maintaining that tissue’s homeostasis, suggesting that only a third of the variation in cancer risk among tissues is attributable to environmental factors or inherited predispositions.
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Epidemiology of Human Papillomavirus–Positive Head and Neck Squamous Cell Carcinoma
TL;DR: Recent data are reviewed to provide insight into several topics, including incidence trends and projections for HPV-positive HNC; the worldwide HPV-attributable fraction; sex disparities in cancer risk; the epidemiology of oral HPV infection; the latency period between infection and cancer; the potential impact of prophylactic HPV vaccination; and prospects for secondary prevention.
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Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
TL;DR: The changing epidemiology, advances in diagnosis, and treatment options for squamous cell cancers of the head and neck, along with data on risk stratification specific to oropharyngeal cancer are focused on, and the direction of current trials is highlighted.
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Oral cavity and oropharyngeal squamous cell carcinoma—an update
TL;DR: In this article, the authors compare and contrast tumors at these two sites with respect to epidemiology, etiopathogenesis, clinicopathologic presentation, clinical assessment, imaging, management, and prognosis.
Journal ArticleDOI
HPV DNA, E6/E7 mRNA, and p16INK4a detection in head and neck cancers: a systematic review and meta-analysis
Cathy Ndiaye,Marisa Mena,Laia Alemany,Marc Arbyn,Xavier Castellsagué,Louise Laporte,F. Xavier Bosch,Silvia de Sanjosé,Helen Trottier +8 more
TL;DR: The contribution of HPV prevalence in head and neck squamous cell carcinoma and in particular that of HPV16 in the oropharynx shows the potential benefit of prophylactic vaccines.
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Book
Cancer Incidence in Five Continents
Freddie Bray,J. Ferlay,Mathieu Laversanne,David H. Brewster,C. Gombe Mbalawa,B. Kohler,Marion Piñeros,Eva Steliarova-Foucher,Rajaraman Swaminathan,Sebastien Antoni,Isabelle Soerjomataram,David Forman +11 more
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Journal ArticleDOI
Permutation tests for joinpoint regression with applications to cancer rates
TL;DR: A joinpoint regression model is applied to describe continuous changes in the recent trend and the grid-search method is used to fit the regression function with unknown joinpoints assuming constant variance and uncorrelated errors.
Journal ArticleDOI
Human Papillomavirus and Rising Oropharyngeal Cancer Incidence in the United States
Anil K. Chaturvedi,Eric A. Engels,Ruth M. Pfeiffer,Brenda Y. Hernandez,Weihong Xiao,Esther Kim,Bo Jiang,Marc T. Goodman,Maria Sibug-Saber,Wendy Cozen,Lihua Liu,Charles F. Lynch,Nicolas Wentzensen,Richard C.K. Jordan,Sean F. Altekruse,William F. Anderson,Philip S. Rosenberg,Maura L. Gillison +17 more
TL;DR: In this article, the prevalence of human papillomavirus (HPV) infection in oropharyngeal cancer was determined for all 271 oropharygeal cancers (1984-2004) collected by the three population-based cancer registries in the Surveillance, Epidemiology, and End Results (SEER) Residual Tissue Repositories Program.
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