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xenografts in immunodeficient mice Live attenuated measles virus induces regression of human lymphoma
Adele Kay Fielding,Deanna M. Grote,Stephen J. Russell,Tatjana I. Cornu,Roberto Cattaneo,Richard G. Vile,Gregory A. Poland +6 more
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The article was published on 2013-01-01 and is currently open access. It has received 0 citations till now. The article focuses on the topics: Measles virus.read more
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An adenovirus mutant that replicates selectively in p53-deficient human tumor cells.
James R. Bischoff,David H. Kirn,Angelica Williams,Carla Heise,Sharon Horn,Mike Muna,Lelia Ng,Julie Nye,Adam Sampson-Johannes,Ali Fattaey,Frank McCormick +10 more
TL;DR: Injection of the mutant virus into p53-deficient human cervical carcinomas grown in nude mice caused a significant reduction in tumor size and caused complete regression of 60 percent of the tumors, raising the possibility that mutant adenoviruses can be used to treat certain human tumors.
Journal ArticleDOI
A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer
Fadlo R. Khuri,John Nemunaitis,Ian Ganly,James Arseneau,Ian F. Tannock,Larry Romel,Martin Gore,J. Ironside,Robert Hugh MacDougall,Carla Heise,Britta Randlev,Ann M. Gillenwater,Patricia A. Bruso,Stanley B. Kaye,Waun Ki Hong,David H. Kirn +15 more
TL;DR: A phase II trial of a combination of intratumoral ONYX-015 injection with cisplatin and 5-fluorouracil in patients with recurrent squamous cell cancer of the head and neck found substantial objective responses, including a high proportion of complete responses.
Journal ArticleDOI
The human CD46 molecule is a receptor for measles virus (Edmonston strain)
TL;DR: Results prove that human CD46 permits cells both to bind measles virus and to support infection and polyclonal antisera against CD46 inhibited virus binding and infection.
Journal ArticleDOI
Human membrane cofactor protein (CD46) acts as a cellular receptor for measles virus.
Denise Naniche,Gayathri Varior-Krishnan,F. Cervoni,Wild Tf,B. Rossi,Chantal Rabourdin-Combe,Denis Gerlier +6 more
TL;DR: Results show that the human CD46 molecule serves as an MV receptor allowing virus-cell binding, fusion, and viral replication and open new perspectives in the study of MV pathogenesis.