YLR099C (ICT1) Encodes a Soluble Acyl-CoA-dependent Lysophosphatidic Acid Acyltransferase Responsible for Enhanced Phospholipid Synthesis on Organic Solvent Stress in Saccharomyces cerevisiae
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TLDR
This study provides a mechanism for organic solvent tolerance from the point of membrane dynamics in S. cerevisiae by reporting for the first time that an increase in the synthesis of phosphatidic acid is responsible for enhanced phospholipid synthesis that confers tolerance to the organic solvent in Saccharomyces Cerevisiae.About:
This article is published in Journal of Biological Chemistry.The article was published on 2008-04-11 and is currently open access. It has received 69 citations till now. The article focuses on the topics: Phosphatidic acid & Lysophosphatidic acid.read more
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FAT SIGNALS - Lipases and Lipolysis in Lipid Metabolism and Signaling
Rudolf Zechner,Robert Zimmermann,Thomas O. Eichmann,Sepp D. Kohlwein,Guenter Haemmerle,Achim Lass,Frank Madeo +6 more
TL;DR: New findings that lipolytic products and intermediates participate in cellular signaling processes and that “lipolytic signaling” is particularly important in many nonadipose tissues unveil a previously underappreciated aspect of lipolysis, which may be relevant for human disease.
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Metabolic engineering of lipid catabolism increases microalgal lipid accumulation without compromising growth
Emily M. Trentacoste,Roshan P. Shrestha,Sarah R. Smith,Corine Glé,Aaron C. Hartmann,Mark Hildebrand,William H. Gerwick,William H. Gerwick +7 more
TL;DR: The targeted knockdown of a multifunctional lipase/phospholipase/acyltransferase increased lipid yields without affecting growth in the diatom Thalassiosira pseudonana, demonstrating that targeted metabolic manipulations can be used to increase lipid accumulation in eukaryotic microalgae without compromising growth.
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Biochemistry and pathophysiology of intravascular and intracellular lipolysis
Stephen G. Young,Rudolf Zechner +1 more
TL;DR: Current views of lipolysis are summarized and the relevance of this process to human disease is highlighted and the molecule that moves lipoprotein lipase from the interstitial spaces to the capillary lumen is highlighted.
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Molecular mechanisms of yeast tolerance and in situ detoxification of lignocellulose hydrolysates
TL;DR: Improved understanding of yeast tolerance and in situ detoxification provide insight into phenotype-genotype relationships, dissection of tolerance mechanisms, and strategies for more tolerant strain development for biofuels applications.
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Acyltransferases and transacylases that determine the fatty acid composition of glycerolipids and the metabolism of bioactive lipid mediators in mammalian cells and model organisms.
Atsushi Yamashita,Yasuhiro Hayashi,Yoko Nemoto-Sasaki,Makoto Ito,Saori Oka,Takashi Tanikawa,Keizo Waku,Takayuki Sugiura +7 more
TL;DR: Recent progresses in acyltransferase research including the identification of the enzyme's genes are described in this review of fatty acid remodeling systems for phospholipids.
References
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The neighbor-joining method: a new method for reconstructing phylogenetic trees.
Naruya Saitou,Masatoshi Nei +1 more
TL;DR: The neighbor-joining method and Sattath and Tversky's method are shown to be generally better than the other methods for reconstructing phylogenetic trees from evolutionary distance data.
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Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.
TL;DR: A method has been devised for the electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets that results in quantitative transfer of ribosomal proteins from gels containing urea.
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A rapid method of total lipid extraction and purification.
E. G. Bligh,W. J. Dyer +1 more
TL;DR: The lipid decomposition studies in frozen fish have led to the development of a simple and rapid method for the extraction and purification of lipids from biological materials that has been applied to fish muscle and may easily be adapted to use with other tissues.
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High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrier.
Robert H. Schiestl,R D Gietz +1 more
TL;DR: A method, using LiAc to yield competent cells, is described that increased the efficiency of genetic transformation of intact cells of Saccharomyces cerevisiae to more than 1 × 105 transformant per microgram of vector DNA and to 1.5% transformants per viable cell.