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Expert opinion: The prospects for mRNA vaccines are very promising.
As new cancer antigens come to the forefront with novel RNA encapsulation and targeting techniques, RNA vaccines may prove to be a vital, safe and robust method to initiate patient-specific anti-tumor efficacy.
This suggests that protein-based vaccines formulated using RNA adjuvant function as live-attenuated vaccines.
Naked, non-infectious, self-replicating RNA may be an excellent candidate for the development of new cancer vaccines.
Based on experience in recent clinical trials, mRNA-based vaccines are a promising novel platform that might be useful for the development of vaccines against emerging pandemic infectious diseases.
Journal ArticleDOI
22 Jun 2012-Vaccine
150 Citations
Possible drawbacks related to the cost and feasibility of manufacturing RNA vaccines are being addressed, increasing the likelihood that RNA-based vaccines will be commercially viable.
From this we conclude that sa-RNA is a promising platform for vaccines against viral diseases.
Therefore, RNA adjuvants have broad applicability and can be used with all conventional vaccines to improve vaccine efficacy qualitatively and quantitively.
Notably, our data demonstrate that mRNA vaccines can compete with licensed vaccines based on inactivated virus or are even superior in respect of functional antibody and T cell responses.