A
Adrian Cassidy
Researcher at University of Liverpool
Publications - 44
Citations - 4959
Adrian Cassidy is an academic researcher from University of Liverpool. The author has contributed to research in topics: Lung cancer & Population. The author has an hindex of 29, co-authored 44 publications receiving 4592 citations. Previous affiliations of Adrian Cassidy include University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25
Rayjean J. Hung,James McKay,Valerie Gaborieau,Paolo Boffetta,Mia Hashibe,David Zaridze,Anush Mukeria,Neonilia Szeszenia-Dabrowska,Jolanta Lissowska,Peter Rudnai,Eleonora Fabianova,Dana Mates,Vladimir Bencko,Lenka Foretova,Vladimir Janout,Chu Chen,Gary E. Goodman,John K. Field,Triantafillos Liloglou,George Xinarianos,Adrian Cassidy,John R. McLaughlin,Geoffrey Liu,Steven A. Narod,Hans E. Krokan,Frank Skorpen,Maiken Bratt Elvestad,Kristian Hveem,Lars J. Vatten,Jakob Linseisen,Françoise Clavel-Chapelon,Paolo Vineis,H. Bas Bueno-de-Mesquita,Eiliv Lund,Carmen Martinez,Sheila Bingham,Torgny Rasmuson,Pierre Hainaut,Elio Riboli,Wolfgang Ahrens,Simone Benhamou,Pagona Lagiou,Dimitrios Trichopoulos,Ivana Holcatova,Franco Merletti,Kristina Kjærheim,Antonio Agudo,Gary J. Macfarlane,Renato Talamini,Lorenzo Simonato,Ray Lowry,David I. Conway,Ariana Znaor,Claire M. Healy,Diana Zelenika,Anne Boland,Marc Delepine,Mario Foglio,Doris Lechner,Fumihiko Matsuda,Hélène Blanché,Ivo Gut,Simon Heath,Mark Lathrop,Paul Brennan +64 more
TL;DR: The results provide compelling evidence of a locus at 15q25 predisposing to lung cancer, and reinforce interest in nicotinic acetylcholine receptors as potential disease candidates and chemopreventative targets.
Journal ArticleDOI
Lung cancer susceptibility locus at 5p15.33
James McKay,Rayjean J. Hung,Rayjean J. Hung,Valerie Gaborieau,Paolo Boffetta,Amelie Chabrier,Graham Byrnes,David Zaridze,Anush Mukeria,Neonilia Szeszenia-Dabrowska,Jolanta Lissowska,Peter Rudnai,Eleonora Fabianova,Dana Mates,Vladimir Bencko,Lenka Foretova,Vladimir Janout,John R. McLaughlin,John R. McLaughlin,Frances A. Shepherd,Alexandre Montpetit,Steven A. Narod,Hans E. Krokan,Frank Skorpen,Maiken Bratt Elvestad,Lars J. Vatten,Inger Njølstad,Tomas Axelsson,Chu Chen,Gary E. Goodman,Matt J. Barnett,Melissa M. Loomis,Jan Lubinski,Joanna Matyjasik,Marcin Lener,Dorota Oszutowska,John K. Field,Triantafillos Liloglou,George Xinarianos,Adrian Cassidy,Diana Zelenika,Anne Boland,Marc Delepine,Mario Foglio,Doris Lechner,Fumihiko Matsuda,Hélène Blanché,Ivo Gut,Simon Heath,Mark Lathrop,Mark Lathrop,Paul Brennan +51 more
TL;DR: The susceptibility region contains two genes, TERT and CLPTM1L, suggesting that one or both may have a role in lung cancer etiology, and two uncorrelated disease markers at 5p15.33 are detected.
Journal ArticleDOI
Cigarette smoking and lung cancer – relative risk estimates for the major histological types from a pooled analysis of case-control studies
Beate Pesch,Benjamin Kendzia,Per Gustavsson,Karl-Heinz Jöckel,Georg Johnen,Hermann Pohlabeln,Ann Olsson,Wolfgang Ahrens,Isabelle M. Gross,Irene Brüske,Heinz Erich Wichmann,Franco Merletti,Lorenzo Richiardi,Lorenzo Simonato,Cristina Fortes,Jack Siemiatycki,Marie-Élise Parent,Dario Consonni,Maria Teresa Landi,Neil E. Caporaso,David Zaridze,Adrian Cassidy,Neonila Szeszenia-Dabrowska,Peter Rudnai,Jolanta Lissowska,Isabelle Stücker,Eleonora Fabianova,Rodica Stanescu Dumitru,Vladimir Bencko,Lenka Foretova,Vladimir Janout,Charles M. Rudin,Paul Brennan,Paolo Boffetta,Kurt Straif,Thomas Brüning +35 more
TL;DR: The major result that smoking exerted a steeper risk gradient on SqCC and SCLC than on AdCa is in line with previous population data and biological understanding of lung cancer development.
Journal ArticleDOI
The LLP risk model: an individual risk prediction model for lung cancer.
Adrian Cassidy,Jonathan P. Myles,M van Tongeren,Richard D. Page,Triantafillos Liloglou,Stephen W. Duffy,John K. Field +6 more
TL;DR: If independent validation studies confirm these results, the LLP risk models’ application as the first stage in an early detection strategy is a logical evolution in patient care.
Journal ArticleDOI
Hypomethylation of retrotransposable elements correlates with genomic instability in non-small cell lung cancer.
Alexandros Daskalos,Georgios Nikolaidis,George Xinarianos,Paraskevi Savvari,Adrian Cassidy,Roubini Zakopoulou,Roubini Zakopoulou,A. Kotsinas,Vassilis G. Gorgoulis,John K. Field,Triantafillos Liloglou +10 more
TL;DR: This study demonstrates the strong link between hypomethylation of transposable elements with genomic instability in non‐small cell lung cancer and provides early evidence for a potential active role of these elements in lung neoplasia.