R
Ray Lowry
Researcher at Newcastle University
Publications - 22
Citations - 3409
Ray Lowry is an academic researcher from Newcastle University. The author has contributed to research in topics: Social marketing & Cancer. The author has an hindex of 13, co-authored 21 publications receiving 3244 citations. Previous affiliations of Ray Lowry include Palacký University, Olomouc & University of Newcastle.
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Journal ArticleDOI
A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25
Rayjean J. Hung,James McKay,Valerie Gaborieau,Paolo Boffetta,Mia Hashibe,David Zaridze,Anush Mukeria,Neonilia Szeszenia-Dabrowska,Jolanta Lissowska,Peter Rudnai,Eleonora Fabianova,Dana Mates,Vladimir Bencko,Lenka Foretova,Vladimir Janout,Chu Chen,Gary E. Goodman,John K. Field,Triantafillos Liloglou,George Xinarianos,Adrian Cassidy,John R. McLaughlin,Geoffrey Liu,Steven A. Narod,Hans E. Krokan,Frank Skorpen,Maiken Bratt Elvestad,Kristian Hveem,Lars J. Vatten,Jakob Linseisen,Françoise Clavel-Chapelon,Paolo Vineis,H. Bas Bueno-de-Mesquita,Eiliv Lund,Carmen Martinez,Sheila Bingham,Torgny Rasmuson,Pierre Hainaut,Elio Riboli,Wolfgang Ahrens,Simone Benhamou,Pagona Lagiou,Dimitrios Trichopoulos,Ivana Holcatova,Franco Merletti,Kristina Kjærheim,Antonio Agudo,Gary J. Macfarlane,Renato Talamini,Lorenzo Simonato,Ray Lowry,David I. Conway,Ariana Znaor,Claire M. Healy,Diana Zelenika,Anne Boland,Marc Delepine,Mario Foglio,Doris Lechner,Fumihiko Matsuda,Hélène Blanché,Ivo Gut,Simon Heath,Mark Lathrop,Paul Brennan +64 more
TL;DR: The results provide compelling evidence of a locus at 15q25 predisposing to lung cancer, and reinforce interest in nicotinic acetylcholine receptors as potential disease candidates and chemopreventative targets.
Journal ArticleDOI
Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Helena Furberg,Yunjung Kim,Jennifer Dackor,Eric Boerwinkle,Nora Franceschini,Diego Ardissino,Luisa Bernardinelli,Luisa Bernardinelli,Pier Mannuccio Mannucci,Francesco Mauri,Piera Angelica Merlini,Devin Absher,Themistocles L. Assimes,Stephen P. Fortmann,Carlos Iribarren,Joshua W. Knowles,Thomas Quertermous,Luigi Ferrucci,Toshiko Tanaka,Joshua C. Bis,Curt D. Furberg,Talin Haritunians,Barbara McKnight,Bruce M. Psaty,Bruce M. Psaty,Kent D. Taylor,Evan L. Thacker,Peter Almgren,Leif Groop,Claes Ladenvall,Michael Boehnke,Anne U. Jackson,Karen L. Mohlke,Heather M. Stringham,Jaakko Tuomilehto,Jaakko Tuomilehto,Emelia J. Benjamin,Shih-Jen Hwang,Daniel Levy,Sarah R. Preis,Ramachandran S. Vasan,Jubao Duan,Pablo V. Gejman,Douglas F. Levinson,Alan R. Sanders,Jianxin Shi,Esther H. Lips,James McKay,Antonio Agudo,Luigi Barzan,Vladimir Bencko,Simone Benhamou,Simone Benhamou,Xavier Castellsagué,Cristina Canova,David I. Conway,Eleonora Fabianova,Lenka Foretova,Vladimir Janout,Claire M. Healy,Ivana Holcatova,Kristina Kjærheim,Pagona Lagiou,Jolanta Lissowska,Ray Lowry,Tatiana V. Macfarlane,Dana Mates,Lorenzo Richiardi,Peter Rudnai,Neonilia Szeszenia-Dabrowska,David Zaridze,Ariana Znaor,Mark Lathrop,Paul Brennan,Stefania Bandinelli,Timothy M. Frayling,Jack M. Guralnik,Yuri Milaneschi,John R. B. Perry,David Altshuler,David Altshuler,Roberto Elosua,S. Kathiresan,S. Kathiresan,Gavin Lucas,Olle Melander,Christopher J. O'Donnell,Veikko Salomaa,Stephen M. Schwartz,Benjamin F. Voight,Brenda W.J.H. Penninx,Johannes H. Smit,Nicole Vogelzangs,Dorret I. Boomsma,Eco J. C. de Geus,Jacqueline M. Vink,Gonneke Willemsen,Stephen J. Chanock,Fangyi Gu,Susan E. Hankinson,David J. Hunter,Albert Hofman,Henning Tiemeier,André G. Uitterlinden,Cornelia M. van Duijn,Stefan Walter,Daniel I. Chasman,Brendan M. Everett,Guillaume Paré,Paul M. Ridker,Ming D. Li,Hermine H. Maes,Janet Audrain-McGovern,Danielle Posthuma,Laura M. Thornton,Caryn Lerman,Jaakko Kaprio,Jaakko Kaprio,Jed E. Rose,John P. A. Ioannidis,John P. A. Ioannidis,Peter Kraft,Danyu Lin,Patrick F. Sullivan +123 more
TL;DR: A meta-analyses of several smoking phenotypes within cohorts of the Tobacco and Genetics Consortium found the strongest association was a synonymous 15q25 SNP in the nicotinic receptor gene CHRNA3, and three loci associated with number of cigarettes smoked per day were identified.
Journal ArticleDOI
A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium
James McKay,Thérèse Truong,Valerie Gaborieau,Amelie Chabrier,Shu Chun Chuang,Graham Byrnes,David Zaridze,Oxana Shangina,Neonila Szeszenia-Dabrowska,Jolanta Lissowska,Peter Rudnai,Eleonora Fabianova,Alexandru Bucur,Vladimir Bencko,Ivana Holcatova,Vladimir Janout,Lenka Foretova,Pagona Lagiou,Dimitrios Trichopoulos,Simone Benhamou,Christine Bouchardy,Wolfgang Ahrens,Franco Merletti,Lorenzo Richiardi,Renato Talamini,Luigi Barzan,Kristina Kjærheim,Gary J. Macfarlane,Tatiana V. Macfarlane,Lorenzo Simonato,Cristina Canova,Cristina Canova,Antonio Agudo,Xavier Castellsagué,Ray Lowry,David I. Conway,Patricia A. McKinney,Claire M. Healy,Mary Toner,Ariana Znaor,Maria Paula Curado,Sergio Koifman,Ana M. B. Menezes,Victor Wünsch-Filho,José Eluf Neto,Leticia Fernández Garrote,Stefania Boccia,Gabriella Cadoni,Dario Arzani,Andrew F. Olshan,Mark C. Weissler,William K. Funkhouser,Jingchun Luo,Jan Lubinski,Joanna Trubicka,Marcin Lener,Dorota Oszutowska,Stephen M. Schwartz,Chu Chen,Sherianne Fish,David R. Doody,Joshua E. Muscat,Philip Lazarus,Carla J. Gallagher,Shen Chih Chang,Zuo-Feng Zhang,Qingyi Wei,Erich M. Sturgis,Li E. Wang,Silvia Franceschi,Rolando Herrero,Karl T. Kelsey,Michael D. McClean,Carmen J. Marsit,Heather H. Nelson,Marjorie Romkes,Shama Buch,Tomoko Nukui,Shilong Zhong,Martin Lacko,Johannes J. Manni,Wilbert H.M. Peters,Rayjean J. Hung,John R. McLaughlin,Lars J. Vatten,Inger Njølstad,Gary E. Goodman,John K. Field,Triantafillos Liloglou,Paolo Vineis,Paolo Vineis,Françoise Clavel-Chapelon,Domenico Palli,Rosario Tumino,Vittorio Krogh,Salvatore Panico,Carlos A. González,J. Ramón Quirós,Carmen Enid Martínez,Carmen Navarro,Eva Ardanaz,Nerea Larrañaga,Kay-Tee Khaw,Timothy J. Key,H. Bas Bueno-de-Mesquita,Petra H.M. Peeters,Antonia Trichopoulou,Jakob Linseisen,Heiner Boeing,Göran Hallmans,Kim Overvad,Anne Tjønneland,Merethe Kumle,Elio Riboli,Kristjan Välk,Tõnu Voodern,Andres Metspalu,Diana Zelenika,Anne Boland,Marc Delepine,Mario Foglio,Doris Lechner,Hélène Blanché,Ivo Gut,Pilar Galan,Simon Heath,Mia Hashibe,Richard B. Hayes,Paolo Boffetta,Mark Lathrop,Paul Brennan +130 more
TL;DR: A genome-wide association study to identify common genetic variation involved in susceptibility to upper aero-digestive tract (UADT) cancers implicate two variants at 4q21 and 12q24 and further highlight three ADH variants in UADT cancer susceptibility.
Journal ArticleDOI
Multiple ADH genes are associated with upper aerodigestive cancers
Mia Hashibe,James McKay,Maria Paula Curado,José Carlos de Oliveira,Sergio Koifman,Rosalina Jorge Koifman,David Zaridze,Oxana Shangina,Victor Wünsch-Filho,José Eluf-Neto,José Eduardo Levi,Elena Matos,Pagona Lagiou,Areti Lagiou,Simone Benhamou,Christine Bouchardy,Neonilia Szeszenia-Dabrowska,Ana M. B. Menezes,Marinel Mór Dall'Agnol,Franco Merletti,Lorenzo Richiardi,Leticia Fernandez,Juan Lence,Renato Talamini,Luigi Barzan,Dana Mates,Ioan Nicolae Mates,Kristina Kjærheim,Gary J Macfarlane,Tatiana V. Macfarlane,L Simonato,Cristina Canova,Ivana Holcatova,Antonio Agudo,Xavier Castellsagué,Ray Lowry,Vladimir Janout,Helena Kollárová,David I. Conway,Patricia A. McKinney,Ariana Znaor,Eleonora Fabianova,Vladimir Bencko,Jolanta Lissowska,Amelie Chabrier,Rayjean J. Hung,Valerie Gaborieau,Paolo Boffetta,Paul Brennan +48 more
TL;DR: Gene variants rs1229984 (ADH1B) and rs1573496 (ADh7) were significantly protective against aerodigestive cancer in each individual study and overall (P = 10−10 and 10−9, respectively).
Journal ArticleDOI
Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals
Esther H. Lips,Valerie Gaborieau,James McKay,Amelie Chabrier,Rayjean J. Hung,Rayjean J. Hung,Paolo Boffetta,Mia Hashibe,David Zaridze,Neonilia Szeszenia-Dabrowska,Jolanta Lissowska,Peter Rudnai,Eleonora Fabianova,Dana Mates,Vladimir Bencko,Lenka Foretova,Vladimir Janout,John K. Field,Triantafillos Liloglou,George Xinarianos,John R. McLaughlin,John R. McLaughlin,Geoffrey Liu,Frank Skorpen,Maiken Bratt Elvestad,Kristian Hveem,Lars J. Vatten,Epic Study,Simone Benhamou,Simone Benhamou,Pagona Lagiou,Ivana Holcatova,Franco Merletti,Kristina Kjærheim,Antonio Agudo,Xavier Castellsagué,Tatiana V. Macfarlane,Luigi Barzan,Cristina Canova,Ray Lowry,David I. Conway,Ariana Znaor,Claire M. Healy,Maria Paula Curado,Sergio Koifman,José Eluf-Neto,Elena Matos,Ana M. B. Menezes,Leticia Fernandez,Andres Metspalu,Simon Heath,Mark Lathrop,Mark Lathrop,Paul Brennan +53 more
TL;DR: This study confirms the strong association between 15q gene variants and LC and shows an independent association with smoking quantity, as well as an association with UADT cancers.