A
Aedín C. Culhane
Researcher at Harvard University
Publications - 98
Citations - 11493
Aedín C. Culhane is an academic researcher from Harvard University. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 42, co-authored 92 publications receiving 8954 citations. Previous affiliations of Aedín C. Culhane include City University of New York & University College Dublin.
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Journal ArticleDOI
The Immune Landscape of Cancer
Vesteinn Thorsson,David L Gibbs,Scott D. Brown,Denise M. Wolf,Dante S. Bortone,Tai-Hsien Ou Yang,Eduard Porta-Pardo,Galen F. Gao,Christopher L. Plaisier,James A. Eddy,Elad Ziv,Aedín C. Culhane,Evan O. Paull,I K Ashok Sivakumar,Andrew J. Gentles,Raunaq Malhotra,Farshad Farshidfar,Antonio Colaprico,Joel S. Parker,Lisle E. Mose,Nam S Vo,Jianfang Liu,Yuexin Liu,Janet S. Rader,Varsha Dhankani,Sheila Reynolds,Reanne Bowlby,Andrea Califano,Andrew D. Cherniack,Dimitris Anastassiou,Davide Bedognetti,Arvind Rao,Ken Chen,Alexander Krasnitz,Hai Hu,Tathiane M. Malta,Houtan Noushmehr,Houtan Noushmehr,Chandra Sekhar Pedamallu,Susan Bullman,Akinyemi I. Ojesina,Andrew Lamb,Wanding Zhou,Hui Shen,Toni K. Choueiri,John N. Weinstein,Justin Guinney,Joel H. Saltz,Robert A. Holt,Charles E Rabkin,Alexander J. Lazar +50 more
TL;DR: An extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA identifies six immune subtypes that encompass multiple cancer types and are hypothesized to define immune response patterns impacting prognosis.
Journal ArticleDOI
Apoptosis: Molecular Regulation of Cell Death
Annette J. Hale,Christopher A. Smith,Leslie C. Sutherland,Victoria E. A. Stoneman,Vanessa L. Longthorne,Aedín C. Culhane,Gwyn T. Williams +6 more
TL;DR: Although apoptosis is now accepted as a critical element in the repertoire of potential cellular responses, the picture of the intra-cellular processes involved is probably still incomplete, not just in its details, but also in the basic outline of the process as a whole.
Journal ArticleDOI
RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites.
Bijan Sobhian,Genze Shao,Dana R. Lilli,Aedín C. Culhane,Lisa A. Moreau,Bing Xia,David M. Livingston,Roger A. Greenberg +7 more
TL;DR: Mutations affecting the BRCT domains of the breast cancer–associated tumor suppressor BRCA1 disrupt the recruitment of this protein to DNA double-strand breaks (DSBs), implicating ubiquitin chain recognition and turnover in the BRCa1-mediated repair of DSBs.
Journal ArticleDOI
Repeatability of published microarray gene expression analyses.
John P. A. Ioannidis,David B. Allison,Catherine A. Ball,Issa Coulibaly,Xiangqin Cui,Aedín C. Culhane,Mario Falchi,Mario Falchi,Cesare Furlanello,Laurence Game,Giuseppe Jurman,Jon Mangion,Tapan Mehta,Michael Nitzberg,Grier P. Page,Grier P. Page,Enrico Petretto,Enrico Petretto,Vera van Noort +18 more
TL;DR: Evaluated the replication of data analyses in 18 articles on microarray-based gene expression profiling published in Nature Genetics in 2005–2006, finding that Repeatability of published microarray studies is apparently limited.
Journal ArticleDOI
Comparison and evaluation of methods for generating differentially expressed gene lists from microarray data
TL;DR: An empirical study in which some of the most commonly used feature selection methods are compared to 9 publicly available datasets, and it is reported that the choice of feature selection method, the number of genes in the genelist, the numbers of cases and the noise in the dataset, substantially influence classification success.