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Afrânio Lineu Kritski
Researcher at Federal University of Rio de Janeiro
Publications - 216
Citations - 3852
Afrânio Lineu Kritski is an academic researcher from Federal University of Rio de Janeiro. The author has contributed to research in topics: Tuberculosis & Mycobacterium tuberculosis. The author has an hindex of 30, co-authored 198 publications receiving 3376 citations. Previous affiliations of Afrânio Lineu Kritski include Universidade Federal de Minas Gerais.
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Journal ArticleDOI
II Consenso Brasileiro de Tuberculose: Diretrizes Brasileiras para Tuberculose 2004
Adauto Castelo Filho,Afrânio Lineu Kritski,Ângela Werneck Barreto,Antônio Carlos Moreira Lemos,Antônio Ruffino Netto,Carlos Alberto Guimarães,Célio Lopes Silva,Clemax Couto Sant'Anna,David Jamil Haddad,Dinalva Soares Lima,Eliana Dias Matos,Fernanda Carvalho de Queiroz Melo,Fernando Augusto Fiuza de Melo,Germano Gerhardt Filho,Giovanni Antonio Marsico,Guida Silva,Helio Ribeiro de Siqueira,Hisbello da Silva Campos,Humberto Saconato,Inês Dourado,José Rosemberg,José Ueleres Braga,Joseney Raimundo dos Santos,Márcia Seiscento,Marcus Barreto Conde,Margareth Pretti Dalcolmo,Margarida Maria Mattos Brito de Almeida,Maria Lúcia Fernandes Penna,Mauricio Lima Barreto,Miguel Aiub Hijjar,Mônica Kramer de Noronha Andrade,Ninarosa Calvazara Cardoso,Norma Irene Soza Pineda,Olavo Henrique Munhoz Leite,Pedro Dornelles Picon,Rodney Luiz Frare e Silva,Solange B. Cavalcanti,Susan Martins Pereira,Valéria Maria Augusto,Vera Maria Neder Galesi,Walkyria Pereira Pinto +40 more
TL;DR: “.” ˛˚ ˛ ˜ˇ 2 ˆ````龍左 𝚘 , 7˚, 7˘ ݘ ンジャック, ݚ വ’ “’Benedictine’s Law”, 2 January 2017.
Journal ArticleDOI
Down-Modulation of Lung Immune Responses by Interleukin-10 and Transforming Growth Factor β (TGF-β) and Analysis of TGF-β Receptors I and II in Active Tuberculosis
M. Glória Bonecini-Almeida,John L. Ho,Neio Boechat,Richard C. Huard,Sadhana Chitale,Howard Doo,Jiayuan Geng,Lorena Rego,Luiz Claudio Oliveira Lazzarini,Luiz Claudio Oliveira Lazzarini,Afrânio Lineu Kritski,Warren D. Johnson,Timothy A. McCaffrey,José Roberto Lapa e Silva +13 more
TL;DR: The data suggest that the combined production of the immunosuppressants IL-10 and TGF-β, as well as coexpression of T GF-β RI and RII, may act to down-modulate host anti-Mycobacterium tuberculosis immunity and thereby allow uncontrolled bacterial replication and overt disease.
Journal ArticleDOI
Tuberculosis Is Associated with a Down-Modulatory Lung Immune Response That Impairs Th1-Type Immunity
Alexandre S. de Almeida,Patrícia Martins Lago,Neio Boechat,Richard C. Huard,Richard C. Huard,Luiz Claudio Oliveira Lazzarini,Luiz Claudio Oliveira Lazzarini,Adalberto R. Santos,Marcelo Nociari,Hongxia Zhu,Beatriz M. Perez-Sweeney,Heejung Bang,Quanhong Ni,Jie Huang,Andrea L. Gibson,Vera C. Flores,Vera C. Flores,Lorena R. Pecanha,Afrânio Lineu Kritski,José Roberto Lapa e Silva,José Roberto Lapa e Silva,John L. Ho,John L. Ho +22 more
TL;DR: Low levels of NO synthase-2 produced by alveolar macrophages at TB diagnosis, along with the heightened amounts of suppressive mediators, support the conclusion that M. tuberculosis actively promotes down-modulatory mediators to counteract Th1-type and innate immunity as an immunopathological strategy.
Journal ArticleDOI
Transmission of tuberculosis to close contacts of patients with multidrug-resistant tuberculosis.
Afrânio Lineu Kritski,M J Marques,Marcelo Fouad Rabahi,M. A. Vieira,Eduardo Werneck-Barroso,Carlos Eduardo Carvalho,G. De Noronha Andrade,R. Bravo-De-Souza,L M Andrade,P P Gontijo,Lee W. Riley +10 more
TL;DR: BCG vaccination appears to offer protection against tuberculosis during prolonged exposures to persons with MDRTB, which identifies a novel and specific indication of BCG use.
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Mutations in katG, inhA, and ahpC genes of Brazilian isoniazid-resistant isolates of Mycobacterium tuberculosis
Márcia Susana Nunes Silva,Simone Gonçalves Senna,Marta Osório Ribeiro,Andréia Rosane de Moura Valim,Maria Alice da Silva Telles,Afrânio Lineu Kritski,Glenn P. Morlock,Robert C. Cooksey,Arnaldo Zaha,Maria Lucia Rosa Rossetti +9 more
TL;DR: The presence of mutations in specific regions of the katG, inhA, and ahpC genes was analyzed with 69 Mycobacterium tuberculosis isoniazid-resistant isolates from three Brazilian states.