A
Aimin Tang
Researcher at Merck & Co.
Publications - 49
Citations - 4220
Aimin Tang is an academic researcher from Merck & Co.. The author has contributed to research in topics: Antibody & Human cytomegalovirus. The author has an hindex of 25, co-authored 47 publications receiving 4020 citations. Previous affiliations of Aimin Tang include United States Military Academy.
Papers
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Journal ArticleDOI
Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity.
John W. Shiver,Tong-Ming Fu,Ling Chen,Danilo R. Casimiro,Mary-Ellen Davies,Robert K. Evans,Zhiqiang Zhang,Adam J. Simon,Wendy L. Trigona,Sheri Dubey,Lingyi Huang,Virginia Harris,Romnie Long,Xiaoping Liang,Larry Handt,William A. Schleif,Lan Zhu,Daniel C. Freed,Natasha Persaud,Liming Guan,Kara Punt,Aimin Tang,Minchun Chen,Keith A. Wilson,Kelly B. Collins,Gwendolyn J. Heidecker,V. Rose Fernandez,Helen C. Perry,Joseph G. Joyce,Karen M. Grimm,James C. Cook,Paul M. Keller,Denise S. Kresock,Henryk Mach,Robert D. Troutman,Lynne Isopi,Donna M. Williams,Zheng Xu,Kathryn E. Bohannon,David B. Volkin,David C. Montefiori,Ayako Miura,Georgia R. Krivulka,Michelle A. Lifton,Marcelo J. Kuroda,Jörn E. Schmitz,Norman L. Letvin,Michael J. Caulfield,Andrew J. Bett,Rima Youil,David C. Kaslow,Emilio A. Emini +51 more
TL;DR: The replication-defective adenovirus is a promising vaccine vector for development of an HIV-1 vaccine and elicited by a replication-incompetent Ad5 vector, used either alone or as a booster inoculation after priming with a DNA vector.
Patent
Pd-1 binding proteins
TL;DR: In this article, a subset of PD-1 binding proteins are employed to modulate the immune system through the manipulation of the PD1 signaling pathway, enhancing host immunity to treat infections and cancer.
Journal ArticleDOI
Comparative immunogenicity in rhesus monkeys of DNA plasmid, recombinant vaccinia virus, and replication-defective adenovirus vectors expressing a human immunodeficiency virus type 1 gag gene
Danilo R. Casimiro,Ling Chen,Tong-Ming Fu,Robert K. Evans,Michael J. Caulfield,Mary-Ellen Davies,Aimin Tang,Minchun Chen,Lingyi Huang,Virginia Harris,Daniel C. Freed,Keith A. Wilson,Sheri Dubey,De-Min Zhu,Denise K. Nawrocki,Henryk Mach,Robert D. Troutman,Lynne Isopi,Donna M. Williams,William M. Hurni,Zheng Xu,Jeffrey G. Smith,Su Wang,Xu Liu,Liming Guan,Romnie Long,Wendy L. Trigona,Gwendolyn J. Heidecker,Helen C. Perry,Natasha Persaud,Timothy J. Toner,Qin Su,Xiaoping Liang,Rima Youil,Michael Chastain,Andrew J. Bett,David B. Volkin,Emilio A. Emini,John W. Shiver +38 more
TL;DR: Results are suggestive of an immunization strategy for humans that is centered on use of the adenovirus vector and in which existing adenavirus immunity may be overcome by combined immunization with adjuvanted DNA and adenvirus vector boosting.
Journal ArticleDOI
Attenuation of Simian Immunodeficiency Virus SIVmac239 Infection by Prophylactic Immunization with DNA and Recombinant Adenoviral Vaccine Vectors Expressing Gag
Danilo R. Casimiro,Fubao Wang,William A. Schleif,Xiaoping Liang,Zhiqiang Zhang,Timothy W. Tobery,Mary-Ellen Davies,Adrian B. McDermott,David H. O’Connor,Arthur Fridman,Ansu Bagchi,Lynda G. Tussey,Andrew J. Bett,Adam C. Finnefrock,Tong-Ming Fu,Aimin Tang,Keith A. Wilson,Minchun Chen,Helen C. Perry,Gwendolyn J. Heidecker,Daniel C. Freed,Anthony Carella,Kara Punt,Kara J. Sykes,Lingyi Huang,Virginia I. Ausensi,Margaret Bachinsky,Usha Sadasivan-Nair,David I. Watkins,Emilio A. Emini,John W. Shiver +30 more
TL;DR: The prophylactic efficacy of DNA and replication-incompetent adenovirus serotype 5 (Ad5) vaccine vectors expressing simian immunodeficiency virus (SIV) Gag was examined in rhesus macaques using an SIVmac239 challenge, and virus control was short-lived.
Journal ArticleDOI
Pentameric complex of viral glycoprotein H is the primary target for potent neutralization by a human cytomegalovirus vaccine
Daniel C. Freed,Qi Tang,Aimin Tang,Fengsheng Li,Xi He,Zhao Huang,Weixu Meng,Lin Xia,Adam C. Finnefrock,Eberhard Durr,Amy S. Espeseth,Danilo R. Casimiro,Ningyan Zhang,John W. Shiver,Dai Wang,Zhiqiang An,Tong-Ming Fu +16 more
TL;DR: This work established a panel of 45 monoclonal antibodies (mAbs) from a rabbit immunized with an experimental vaccine virus in which the expression of the pentameric gH complex was restored, establishing this antigen as the key for potent antiviral antibodies by vaccination.