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Andrew Kirby
Researcher at Harvard University
Publications - 36
Citations - 15705
Andrew Kirby is an academic researcher from Harvard University. The author has contributed to research in topics: Single-nucleotide polymorphism & Genome-wide association study. The author has an hindex of 28, co-authored 36 publications receiving 14101 citations. Previous affiliations of Andrew Kirby include Broad Institute & Allegheny University of the Health Sciences.
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Journal ArticleDOI
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
Shaun Purcell,Shaun Purcell,Naomi R. Wray,Jennifer Stone,Jennifer Stone,Peter M. Visscher,Michael Conlon O'Donovan,Patrick F. Sullivan,Pamela Sklar,Pamela Sklar,Douglas M. Ruderfer,Andrew McQuillin,Derek W. Morris,Colm O'Dushlaine,Aiden Corvin,Peter Holmans,Stuart MacGregor,Hugh Gurling,Douglas Blackwood,Nicholas John Craddock,Michael Gill,Christina M. Hultman,Christina M. Hultman,George Kirov,Paul Lichtenstein,Walter J. Muir,Michael John Owen,Carlos N. Pato,Edward M. Scolnick,Edward M. Scolnick,David St Clair,Nigel Williams,Lyudmila Georgieva,Ivan Nikolov,Nadine Norton,Hywel Williams,Draga Toncheva,Vihra Milanova,Emma Flordal Thelander,Patrick Sullivan,Elaine Kenny,Emma M. Quinn,Khalid Choudhury,Susmita Datta,Jonathan Pimm,Srinivasa Thirumalai,Vinay Puri,Robert Krasucki,Jacob Lawrence,Digby Quested,Nicholas Bass,Caroline Crombie,Gillian Fraser,Soh Leh Kuan,Nicholas Walker,Kevin A. McGhee,Ben S. Pickard,P. Malloy,Alan W Maclean,Margaret Van Beck,Michele T. Pato,Helena Medeiros,Frank A. Middleton,Célia Barreto Carvalho,Christopher P. Morley,Ayman H. Fanous,David V. Conti,James A. Knowles,Carlos Ferreira,António Macedo,M. Helena Azevedo,Andrew Kirby,Andrew Kirby,Manuel A. R. Ferreira,Manuel A. R. Ferreira,Mark J. Daly,Mark J. Daly,Kimberly Chambert,Finny G Kuruvilla,Stacey Gabriel,Kristin G. Ardlie,Jennifer L. Moran +81 more
TL;DR: The extent to which common genetic variation underlies the risk of schizophrenia is shown, using two analytic approaches, and the major histocompatibility complex is implicate, which is shown to involve thousands of common alleles of very small effect.
Journal ArticleDOI
Efficient Control of Population Structure in Model Organism Association Mapping
Hyun Min Kang,Noah Zaitlen,Claire M. Wade,Claire M. Wade,Andrew Kirby,Andrew Kirby,David Heckerman,Mark J. Daly,Mark J. Daly,Eleazar Eskin +9 more
TL;DR: A new method, efficient mixed-model association (EMMA), which corrects for population structure and genetic relatedness in model organism association mapping and takes advantage of the specific nature of the optimization problem in applying mixed models for association mapping, which allows for substantially increase the computational speed and reliability of the results.
Journal ArticleDOI
Patterns and rates of exonic de novo mutations in autism spectrum disorders
Benjamin M. Neale,Yan Kou,Li Liu,Avi Ma'ayan,Kaitlin E. Samocha,Kaitlin E. Samocha,Aniko Sabo,Chiao-Feng Lin,Christine Stevens,Li-San Wang,Vladimir Makarov,Paz Polak,Paz Polak,Seungtai Yoon,Jared Maguire,Emily L. Crawford,Nicholas G. Campbell,Evan T. Geller,Otto Valladares,Chad M. Schafer,Han Liu,Tuo Zhao,Guiqing Cai,Jayon Lihm,Ruth Dannenfelser,Omar Jabado,Zuleyma Peralta,Uma Nagaswamy,Donna M. Muzny,Jeffrey G. Reid,Irene Newsham,Yuanqing Wu,Lora Lewis,Yi Han,Benjamin F. Voight,Benjamin F. Voight,Elaine T. Lim,Elaine T. Lim,Elizabeth J. Rossin,Elizabeth J. Rossin,Andrew Kirby,Andrew Kirby,Jason Flannick,Menachem Fromer,Menachem Fromer,Khalid Shakir,Timothy Fennell,Kiran V. Garimella,Eric Banks,Ryan Poplin,Stacey Gabriel,Mark A. DePristo,Jack R. Wimbish,Braden E. Boone,Shawn Levy,Catalina Betancur,Shamil R. Sunyaev,Shamil R. Sunyaev,Eric Boerwinkle,Eric Boerwinkle,Joseph D. Buxbaum,Edwin H. Cook,Bernie Devlin,Richard A. Gibbs,Kathryn Roeder,Gerard D. Schellenberg,James S. Sutcliffe,Mark J. Daly,Mark J. Daly +68 more
TL;DR: Results from de novo events and a large parallel case–control study provide strong evidence in favour of CHD8 and KATNAL2 as genuine autism risk factors and support polygenic models in which spontaneous coding mutations in any of a large number of genes increases risk by 5- to 20-fold.
Journal ArticleDOI
Integrated detection and population-genetic analysis of SNPs and copy number variation
Steven A. McCarroll,Finny G Kuruvilla,Joshua M. Korn,Simon Cawley,James Nemesh,Alec Wysoker,Michael H. Shapero,Paul I.W. de Bakker,Paul I.W. de Bakker,Paul I.W. de Bakker,Julian Maller,Andrew Kirby,Amanda F. Elliott,Melissa Parkin,Earl Hubbell,Teresa Webster,Rui Mei,James Veitch,Patrick J Collins,Robert E. Handsaker,Steve Lincoln,Marcia M. Nizzari,John E. Blume,Keith W. Jones,Rich Rava,Mark J. Daly,Stacey Gabriel,David Altshuler +27 more
TL;DR: A map of human CNV (at 2-kb breakpoint resolution) informed by integer genotypes for 1,320 copy number polymorphisms (CNPs) that segregate at an allele frequency >1% is developed, indicating that large (>100 kb) CNVs affect much less of the genome than initially reported.
Journal ArticleDOI
A framework for the interpretation of de novo mutation in human disease
Kaitlin E. Samocha,Elise B. Robinson,Stephen Sanders,Christine Stevens,Aniko Sabo,Lauren M. McGrath,Jack A. Kosmicki,Karola Rehnström,Swapan Mallick,Andrew Kirby,Dennis P. Wall,Daniel G. MacArthur,Daniel G. MacArthur,Stacey Gabriel,Mark A. DePristo,Shaun Purcell,Shaun Purcell,Shaun Purcell,Aarno Palotie,Eric Boerwinkle,Joseph D. Buxbaum,Edwin H. Cook,Richard A. Gibbs,Gerard D. Schellenberg,James S. Sutcliffe,Bernie Devlin,Kathryn Roeder,Benjamin M. Neale,Benjamin M. Neale,Mark J. Daly,Mark J. Daly +30 more
TL;DR: This model is used to identify ∼1,000 genes that are significantly lacking in functional coding variation in non-ASD samples and are enriched for de novo loss-of-function mutations identified in ASD cases, suggesting that the role of de noVO mutations in ASDs might reside in fundamental neurodevelopmental processes.