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Alain M. Guillem
Researcher at Instituto Politécnico Nacional
Publications - 7
Citations - 359
Alain M. Guillem is an academic researcher from Instituto Politécnico Nacional. The author has contributed to research in topics: Glutamatergic & Glutamate receptor. The author has an hindex of 6, co-authored 7 publications receiving 264 citations.
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Journal ArticleDOI
Synaptopathies: synaptic dysfunction in neurological disorders - A review from students to students
Katarzyna Lepeta,Mychael V. Lourenco,Barbara Schweitzer,Pamela V. Martino Adami,Priyanjalee Banerjee,Silvina Catuara-Solarz,Mario de la Fuente Revenga,Alain M. Guillem,Mouna Haidar,Omamuyovwi M. Ijomone,Bettina Nadorp,Lin Qi,Nirma D Perera,Louise K. Refsgaard,Kimberley M. Reid,Mariam Sabbar,Arghyadip Sahoo,Natascha Schaefer,Rebecca K. Sheean,Anna Suska,Rajkumar Verma,Cinzia Vicidomini,Dean J. Wright,Xingding Zhang,Constanze I. Seidenbecher +24 more
TL;DR: Basic concepts of synapse structure and function are discussed, and a critical view of how aberrant synapse physiology may contribute to neurodevelopmental disorders as well as neurodegenerative disorders are provided.
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GLAST/EAAT1-induced Glutamine release via SNAT3 in Bergmann glial cells: evidence of a functional and physical coupling
Zila Martínez-Lozada,Alain M. Guillem,Marco Flores-Méndez,Luisa C. Hernández-Kelly,Carmelita Vela,Enrique Meza,Rossana C. Zepeda,Mario Caba,Angelina Rodríguez,Arturo Ortega +9 more
TL;DR: The results suggest that glial cells surrounding glutamatergic synapses may act as sensors of neuron‐derived glutamate through their contribution to the neurotransmitter turnover.
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Glutamate Transporter-Dependent mTOR Phosphorylation in Müller Glia Cells
TL;DR: The results showed that D-Asp transport induces the time- and dose-dependent phosphorylation of mTOR, mimicked by the transportable GLAST inhibitor THA (threo-β-hydroxyaspartate).
Journal ArticleDOI
Brain-derived neurotrophic factor and its receptors in Bergmann glia cells
Irais Poblete-Naredo,Alain M. Guillem,Claudia Juárez,Rossana C. Zepeda,Leticia Ramírez,Mario Caba,Luisa C. Hernández-Kelly,Luisa C. Hernández-Kelly,José Aguilera,Esther López-Bayghen,Arturo Ortega +10 more
TL;DR: It is shown that Bergmann glia cells are able to express and respond to BDNF stimulation favoring the notion of their pivotal role in neuroprotection and reverse transcription-polymerase chain reaction experiments predicted the expression of full-length and truncated TrkB isoforms.
Journal ArticleDOI
GLAST/EAAT1 regulation in cultured Bergmann glia cells: role of the NO/cGMP signaling pathway.
Alberto Balderas,Alain M. Guillem,Zila Martínez-Lozada,Luisa C. Hernández-Kelly,José Aguilera,Arturo Ortega +5 more
TL;DR: Investigation of the plausible role of the nitric oxide/cGMP-signaling pathway in the regulation of Bergmann glia glutamate transporters provides an insight into the physiological role of cGMP in the cerebellum.