Priyanjalee Banerjee

TL;DR: Basic concepts of synapse structure and function are discussed, and a critical view of how aberrant synapse physiology may contribute to neurodevelopmental disorders as well as neurodegenerative disorders are provided.

TL;DR: The biology of NF-κB and its activation by reactive oxygen species (ROS) and proinflammatory cytokines in the pathogenesis of AD have been specially highlighted citing evidence both from post-mortem studies in AD brain and experimental research in animal or cell-based models of AD.

TL;DR: The review suggests that the oxidative stress could be an early event in the disease process and may trigger various adaptive responses such as the alterations of amyloid beta metabolism and the activation of stress responsive kinases which can subsequently lead to neuronal degeneration and AD pathology.

TL;DR: It is suggested that intracellularly accumulated α‐synuclein can interact with mitochondria in intact SHSY5Y cells causing dysfunction of the organelle which drives the cell death under the authors' experimental conditions, which has clear implications in the pathogenesis of sporadic Parkinson's disease.

TL;DR: Exogenously added iron in the form of ferric ammonium citrate leads to considerable accumulation of amyloid precursor protein (APP) without a corresponding change in the concerned gene expression in cultured SHSY5Y cells during exposure up to 48 h, providing the initial evidence of potential therapeutic effects of negletein.