K
Katarzyna Lepeta
Researcher at Nencki Institute of Experimental Biology
Publications - 6
Citations - 352
Katarzyna Lepeta is an academic researcher from Nencki Institute of Experimental Biology. The author has contributed to research in topics: Synaptic plasticity & Synaptic scaling. The author has an hindex of 4, co-authored 4 publications receiving 246 citations.
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Journal ArticleDOI
Synaptopathies: synaptic dysfunction in neurological disorders - A review from students to students
Katarzyna Lepeta,Mychael V. Lourenco,Barbara Schweitzer,Pamela V. Martino Adami,Priyanjalee Banerjee,Silvina Catuara-Solarz,Mario de la Fuente Revenga,Alain M. Guillem,Mouna Haidar,Omamuyovwi M. Ijomone,Bettina Nadorp,Lin Qi,Nirma D Perera,Louise K. Refsgaard,Kimberley M. Reid,Mariam Sabbar,Arghyadip Sahoo,Natascha Schaefer,Rebecca K. Sheean,Anna Suska,Rajkumar Verma,Cinzia Vicidomini,Dean J. Wright,Xingding Zhang,Constanze I. Seidenbecher +24 more
TL;DR: Basic concepts of synapse structure and function are discussed, and a critical view of how aberrant synapse physiology may contribute to neurodevelopmental disorders as well as neurodegenerative disorders are provided.
Journal ArticleDOI
Matrix Metalloproteinase-9 as a Novel Player in Synaptic Plasticity and Schizophrenia
TL;DR: This commentary critically reviews findings based on the hypothesis that MMP-9 contributes to pathological synaptic plasticity in schizophrenia.
Journal ArticleDOI
The malleable brain: plasticity of neural circuits and behavior – a review from students to students
Natascha Schaefer,Carola Rotermund,Eva-Maria Blumrich,Mychael V. Lourenco,Pooja Joshi,Regina U Hegemann,Sumit Jamwal,Nilufar Ali,Ezra Michelet García Romero,Sorabh Sharma,Shampa Ghosh,Jitendra Kumar Sinha,Hannah Loke,Hannah Loke,Vishal Jain,Katarzyna Lepeta,Ahmad Salamian,Mahima Sharma,Mojtaba Golpich,Katarzyna Nawrotek,Ramesh Kumar Paidi,Sheila M. Shahidzadeh,Tetsadê C. B. Piermartiri,Elham Amini,Verónica Pastor,Yvette M. Wilson,Philip Adeyemi Adeniyi,Ashok Kumar Datusalia,Benham Vafadari,Vedangana Saini,Edna Suárez-Pozos,Neetu Kushwah,Paula Fontanet,Anthony J. Turner +33 more
TL;DR: A review of the role of plasticity during development and the persistent changes of neural circuitry occurring when sensory input is altered during critical developmental stages, and the signaling cascades resulting in the synthesis of new plasticity‐related proteins, which ultimately enable sustained changes in synaptic strength.
Journal ArticleDOI
A normal genetic variation modulates synaptic MMP-9 protein levels and the severity of schizophrenia symptoms
Katarzyna Lepeta,Katarzyna J. Purzycka,Katarzyna Pachulska-Wieczorek,Marina Mitjans,Martin Begemann,Behnam Vafadari,Krystian Bijata,Ryszard W. Adamiak,Hannelore Ehrenreich,Magdalena Dziembowska,Leszek Kaczmarek +10 more
TL;DR: A novel mechanism that involves M MP‐9‐dependent changes in dendritic spine morphology and the pathophysiology of schizophrenia is proposed, providing the first mechanistic insights into the way in which the single base change in the MMP‐9 gene (rs20544) influences gene function and results in phenotypic changes observed in schizophrenia patients.
Book ChapterDOI
Studying Protein Function Using Nanobodies and Other Protein Binders in Drosophila.
TL;DR: The direct manipulation of proteins by nanobodies and other protein binders has become an additional and valuable approach to investigate development and homeostasis in Drosophila as discussed by the authors .