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Aleš Obr
Researcher at Palacký University, Olomouc
Publications - 26
Citations - 625
Aleš Obr is an academic researcher from Palacký University, Olomouc. The author has contributed to research in topics: Mantle cell lymphoma & Lenalidomide. The author has an hindex of 7, co-authored 23 publications receiving 200 citations.
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Journal ArticleDOI
Tafasitamab plus lenalidomide in relapsed or refractory diffuse large B-cell lymphoma (L-MIND): a multicentre, prospective, single-arm, phase 2 study.
Gilles Salles,Johannes Duell,Eva González Barca,Olivier Tournilhac,Wojciech Jurczak,Anna Marina Liberati,Zsolt Nagy,Aleš Obr,Gianluca Gaidano,Marc André,Nagesh Kalakonda,Martin Dreyling,Johannes Weirather,Maren Dirnberger-Hertweck,Sumeet Ambarkhane,Günter Fingerle-Rowson,Kami J. Maddocks +16 more
TL;DR: Tafasitamab in combination with lenalidomide was well tolerated and resulted in a high proportion of patients with relapsed or refractory diffuse large B-cell lymphoma having an objective response according to the 2007 International Working Group response criteria for malignant lymphoma.
Journal ArticleDOI
COVID-19 infection in adult patients with hematological malignancies: a European Hematology Association Survey (EPICOVIDEHA).
Livio Pagano,Livio Pagano,Jon Salmanton-García,Francesco Marchesi,Alessandro Busca,Paolo Corradini,Martin Hoenigl,Martin Hoenigl,Nikolai Klimko,Philipp Koehler,Antonio Pagliuca,Francesco Passamonti,Luisa Verga,Benjamin Víšek,Osman Ilhan,Gianpaolo Nadali,Barbora Weinbergerova,Raúl Córdoba-Mascuñano,Monia Marchetti,Graham P. Collins,Francesca Farina,Chiara Cattaneo,Alba Cabirta,Maria Gomes-Silva,Federico Itri,Jaap van Doesum,Marie-Pierre Ledoux,Martin Čerňan,Ozren Jakšić,Rafael F. Duarte,Gabriele Magliano,Ali S. Omrani,Nicola Stefano Fracchiolla,Austin G. Kulasekararaj,Austin G. Kulasekararaj,Toni Valković,Christian Bjørn Poulsen,Marina Machado,Andreas Glenthøj,Igor Stoma,Zdeněk Ráčil,Klára Piukovics,Milan Navrátil,Ziad Emarah,Uluhan Sili,Johan Maertens,Ola Blennow,Rui Bergantim,Carolina García-Vidal,Lucia Prezioso,Anna Guidetti,Maria Ilaria Del Principe,Marina Popova,Nick de Jonge,Irati Ormazabal-Vélez,Noemí Fernández,Iker Falces-Romero,Annarosa Cuccaro,Stef Meers,Caterina Buquicchio,Darko Antic,Murtadha Al-Khabori,Ramón García-Sanz,Monika Biernat,Maria Chiara Tisi,Ertan Sal,Laman Rahimli,Natasa Colovic,Martin Schönlein,Maria Calbacho,Carlo Tascini,Carolina Miranda-Castillo,Nina Khanna,Gustavo-Adolfo Méndez,Verena Petzer,Jan Novák,Caroline Besson,Rémy Duléry,Sylvain Lamure,Marcio Nucci,Giovanni Zambrotta,Pavel Žák,Guldane Cengiz Seval,Valentina Bonuomo,Jiří Mayer,Alberto López-García,Maria Vittoria Sacchi,Stephen Booth,Fabio Ciceri,Margherita Oberti,Marco Salvini,Macarena Izuzquiza,Raquel Nunes-Rodrigues,Emanuele Ammatuna,Aleš Obr,Raoul Herbrecht,Lucía Núñez-Martín-Buitrago,Valentina Mancini,Hawraa M Shwaylia,Mariarita Sciumè,Jenna Essame,Marietta Nygaard,Josip Batinić,Josip Batinić,Yung Gonzaga,Isabel Regalado-Artamendi,Linda Katharina Karlsson,Maryia Shapetska,Michaela Hanakova,Shaimaa El-Ashwah,Zita Borbényi,Gökçe Melis Çolak,Anna Nordlander,Giulia Dragonetti,Giulia Dragonetti,Alessio Maria Edoardo Maraglino,Alessio Maria Edoardo Maraglino,Amelia Rinaldi,Cristina De Ramón-Sánchez,Oliver A Cornely +119 more
TL;DR: In this paper, the authors studied the risk factors for adverse outcomes in patients with hematological malignancies (HM) who developed COVID-19 and analyzed predictors of mortality.
Journal ArticleDOI
Long-term outcomes from the Phase II L-MIND study of tafasitamab (MOR208) plus lenalidomide in patients with relapsed or refractory diffuse large B-cell lymphoma.
Johannes Duell,Kami J. Maddocks,Eva González-Barca,Wojciech Jurczak,Anna Marina Liberati,Sven de Vos,Zsolt Nagy,Aleš Obr,Gianluca Gaidano,Pau Abrisqueta,Nagesh Kalakonda,Marc André,Martin Dreyling,Tobias Menne,Olivier Tournilhac,Marinela Augustin,Andreas Rosenwald,Maren Dirnberger-Hertweck,Johannes Weirather,Sumeet Ambarkhane,Gilles Salles +20 more
TL;DR: Tafasitamab (MOR208) as discussed by the authors is an Fc-modified, humanized, anti-CD19 monoclonal antibody combined with the immunomodulatory drug lenalidomide was clinically active with a good tolerability profile in the open-label, single-arm, phase II L-MIND study of patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL) ineligible for autologous stem-cell transplantation.
Journal ArticleDOI
Phase 1/2a study of 177Lu-lilotomab satetraxetan in relapsed/refractory indolent non-Hodgkin lymphoma.
Arne Kolstad,Timothy M Illidge,Nils Bolstad,Signe Spetalen,Ulf Madsbu,Caroline Stokke,Johan Blakkisrud,Ayca Løndalen,Noelle O'Rourke,Matthew Beasley,Wojciech Jurczak,Unn-Merete Fagerli,Michal Kaščák,Mike Bayne,Aleš Obr,Jostein Dahle,Lisa Rojkjaer,Veronique Pascal,Harald Holte +18 more
TL;DR: 177Lu-lilotomab satetraxetan may provide a valuable alternative treatment approach in relapsed/refractory non-Hodgkin lymphoma, particularly in patients with comorbidities unsuitable for more intensive approaches.
Journal ArticleDOI
Concurrent TP53 and CDKN2A Gene Aberrations in Newly Diagnosed Mantle Cell Lymphoma Correlate with Chemoresistance and Call for Innovative Upfront Therapy
Diana Malarikova,Adela Berkova,Aleš Obr,P. Blahovcova,Michael Svaton,Kristina Forsterova,Eva Kriegova,Eva Prihodova,Lenka Pavlistova,Anna Petrackova,Zuzana Zemanova,Marek Trneny,Pavel Klener +12 more
TL;DR: Patients with concurrent aberration of TP53 and CDKN2A should be offered innovative anti-lymphoma therapy and upfront consolidation with allogeneic stem cell transplantation as a new, simple, and relevant index of chemoresistance in MCL.