D
Daniel S. Day
Researcher at Massachusetts Institute of Technology
Publications - 27
Citations - 6175
Daniel S. Day is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Gene & Enhancer. The author has an hindex of 20, co-authored 25 publications receiving 4780 citations. Previous affiliations of Daniel S. Day include Harvard University.
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Journal ArticleDOI
Coactivator condensation at super-enhancers links phase separation and gene control
Benjamin R. Sabari,Alessandra Dall’Agnese,Ann Boija,Isaac A. Klein,Isaac A. Klein,Eliot L. Coffey,Krishna Shrinivas,Brian J. Abraham,Nancy M. Hannett,Alicia V. Zamudio,John C. Manteiga,Charles H. Li,Yang Eric Guo,Daniel S. Day,Jurian Schuijers,Eliza Vasile,Sohail Malik,Denes Hnisz,Tong Ihn Lee,Ibrahim I Cisse,Robert G. Roeder,Phillip A. Sharp,Arup K. Chakraborty,Richard A. Young +23 more
TL;DR: It is postulated that super-enhancers are phase-separated multimolecular assemblies, also known as biomolecular condensates, which provide a means to compartmentalize and concentrate biochemical reactions within cells.
Journal ArticleDOI
Activation of proto-oncogenes by disruption of chromosome neighborhoods
Denes Hnisz,Abraham S. Weintraub,Daniel S. Day,Anne-Laure Valton,Rasmus O. Bak,Charles H. Li,Johanna Goldmann,Bryan R. Lajoie,Zi Peng Fan,Alla A. Sigova,Jessica Reddy,Diego Borges-Rivera,Tong Ihn Lee,Rudolf Jaenisch,Matthew H. Porteus,Job Dekker,Job Dekker,Richard A. Young +17 more
TL;DR: Insulated neighborhoods in T cell acute lymphoblastic leukemia (T-ALL) are mapped and it is found that tumor cell genomes contain recurrent microdeletions that eliminate the boundary sites of insulated neighborhoods containing prominent T-ALL proto-oncogenes.
Journal ArticleDOI
YY1 Is a Structural Regulator of Enhancer-Promoter Loops
Abraham S. Weintraub,Charles H. Li,Alicia V. Zamudio,Alla A. Sigova,Nancy M. Hannett,Daniel S. Day,Brian J. Abraham,Malkiel A. Cohen,Behnam Nabet,Dennis L. Buckley,Yang Eric Guo,Denes Hnisz,Rudolf Jaenisch,James E. Bradner,Nathanael S. Gray,Richard A. Young +15 more
TL;DR: It is shown that the ubiquitously expressed transcription factor Yin Yang 1 (YY1) contributes to enhancer-promoter structural interactions in a manner analogous to DNA interactions mediated by CTCF.
Activation of proto-oncogenes by disruption of chromosome neighborhoods
Denes Hnisz,Daniel S. Day,Anne-Laure Valton,Rasmus O. Bak,Johanna Goldmann,Bryan R. Lajoie,Alla A. Sigova,Tong Ihn Lee,Matthew H. Porteus,Job Dekker,Abraham S. Weintraub,Charles H. Li,Jessica Reddy,Diego Borges-Rivera,Rudolf Jaenisch,Zi Peng Fan,Richard A. Young +16 more
TL;DR: Wala et al. as discussed by the authors investigated whether proto-oncogenes occur within these structures and whether oncogene activation can occur via disruption of insulated neighborhood boundaries in cancer cells.
Journal ArticleDOI
An assessment of histone-modification antibody quality
Thea A. Egelhofer,Aki Minoda,Aki Minoda,Sarit Klugman,Sarit Klugman,Kyungjoon Lee,P. Kolasinska-Zwierz,Artyom A. Alekseyenko,Ming Sin Cheung,Daniel S. Day,Sarah Gadel,Andrey A. Gorchakov,Tingting Gu,Peter V. Kharchenko,Samantha Kuan,Samantha Kuan,Isabel J. Latorre,Daniela Linder-Basso,Ying Luu,Ying Luu,Que-Minh Ngo,Que-Minh Ngo,Marc D. Perry,Andreas Rechtsteiner,Nicole C. Riddle,Yuri B. Schwartz,Gregory A. Shanower,A. Vielle,Julie Ahringer,Sarah C. R. Elgin,Mitzi I. Kuroda,Vincenzo Pirrotta,Bing Ren,Bing Ren,Susan Strome,Peter J. Park,Gary H. Karpen,Gary H. Karpen,R. David Hawkins,R. David Hawkins,Jason D. Lieb +40 more
TL;DR: The specificity and utility of histone-modification antibodies raised against 57 different histone modifications in Drosophila melanogaster, Caenorhabditis elegans and human cells are tested.