A
Alexandra L. Garnham
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 55
Citations - 1158
Alexandra L. Garnham is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 14, co-authored 37 publications receiving 674 citations. Previous affiliations of Alexandra L. Garnham include University of Melbourne & La Trobe University.
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Journal ArticleDOI
Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth
Jonathan B. Baell,Jonathan B. Baell,David J. Leaver,S.J. Hermans,Gemma L. Kelly,Gemma L. Kelly,Margs S. Brennan,Margs S. Brennan,Natalie L. Downer,Nghi H. Nguyen,Johannes Wichmann,Johannes Wichmann,Helen M. McRae,Helen M. McRae,Yuquing Yang,Yuquing Yang,Benjamin Cleary,H. Rachel Lagiakos,Stephen Mieruszynski,Stephen Mieruszynski,Guido Pacini,Hannah K. Vanyai,Hannah K. Vanyai,Maria I. Bergamasco,Maria I. Bergamasco,Rose E. May,Bethany K. Davey,Kimberly J. Morgan,Kimberly J. Morgan,Andrew J. Sealey,Andrew J. Sealey,Beinan Wang,Beinan Wang,Beinan Wang,Natasha Zamudio,Natasha Zamudio,Stephen Wilcox,Stephen Wilcox,Alexandra L. Garnham,Alexandra L. Garnham,Bilal N. Sheikh,Bilal N. Sheikh,Brandon J. Aubrey,Brandon J. Aubrey,Karen Doggett,Karen Doggett,M.C. Chung,Melanie de Silva,John D. Bentley,Pat Pilling,Meghan Hattarki,Olan Dolezal,Matthew L. Dennis,Hendrik Falk,Hendrik Falk,Bin Ren,Susan A. Charman,Karen L. White,Jai Rautela,Jai Rautela,Andrea Newbold,Edwin D. Hawkins,Edwin D. Hawkins,Ricky W. Johnstone,Nicholas D. Huntington,Nicholas D. Huntington,Thomas S. Peat,Joan K. Heath,Joan K. Heath,Andreas Strasser,Andreas Strasser,Michael W. Parker,Michael W. Parker,Gordon K. Smyth,Gordon K. Smyth,Ian P. Street,Ian P. Street,Brendon J. Monahan,Brendon J. Monahan,Anne K. Voss,Anne K. Voss,Tim Thomas,Tim Thomas +82 more
TL;DR: Biochemical and structural studies demonstrate that these compounds are reversible competitors of acetyl coenzyme A and inhibit MYST-catalysed histone acetylation, induce cell cycle exit and cellular senescence without causing DNA damage, and arrest lymphoma progression in mouse models.
Journal ArticleDOI
The neuropeptide VIP confers anticipatory mucosal immunity by regulating ILC3 activity.
Cyril Seillet,Cyril Seillet,Kylie Luong,Kylie Luong,Julie Tellier,Julie Tellier,Nicolas Jacquelot,Nicolas Jacquelot,Rui Dong Shen,Rui Dong Shen,Peter Hickey,Peter Hickey,Verena C. Wimmer,Verena C. Wimmer,Lachlan Whitehead,Lachlan Whitehead,Kelly L. Rogers,Kelly L. Rogers,Gordon K. Smyth,Gordon K. Smyth,Alexandra L. Garnham,Alexandra L. Garnham,Matthew E. Ritchie,Matthew E. Ritchie,Gabrielle T. Belz,Gabrielle T. Belz,Gabrielle T. Belz +26 more
TL;DR: The enteric neuron-derived neuropeptide VIP signals though its receptor VIPR on ILC3s to regulate the cyclic production of IL-22 in response to food intake and synchronize protection of the intestinal epithelium through a VIP–VIPR2 pathway in I LC3s.
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An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell
Michael J Coffey,Brad E. Sleebs,Brad E. Sleebs,Alessandro D. Uboldi,Alessandro D. Uboldi,Alexandra L. Garnham,Alexandra L. Garnham,Magdalena Franco,Nicole D. Marino,Michael W. Panas,David J. P. Ferguson,Marta Enciso,Matthew T. O'Neill,Sash Lopaticki,Rebecca Stewart,Rebecca Stewart,Grant Dewson,Grant Dewson,Gordon K. Smyth,Gordon K. Smyth,Brian J. Smith,Seth L. Masters,Seth L. Masters,John C. Boothroyd,Justin A Boddey,Justin A Boddey,Christopher J. Tonkin,Christopher J. Tonkin +27 more
TL;DR: This work characterizes the first identified machinery required for export of Toxoplasma effectors into the infected host cell, and demonstrates that ASP5 cleaves a highly constrained amino acid motif that has similarity to the PEXEL-motif of Plasmodium parasites.
Journal ArticleDOI
The TNF Receptor Superfamily-NF-κB Axis Is Critical to Maintain Effector Regulatory T Cells in Lymphoid and Non-lymphoid Tissues
Ajithkumar Vasanthakumar,Ajithkumar Vasanthakumar,Yang Liao,Peggy P Teh,Maria Fernanda Pascutti,Anna E. Oja,Alexandra L. Garnham,Alexandra L. Garnham,Renee Gloury,Renee Gloury,Jessica C Tempany,Tom Sidwell,Tom Sidwell,Eloy Cuadrado,Paul Tuijnenburg,Taco W. Kuijpers,Najoua Lalaoui,Lisa A. Mielke,Lisa A. Mielke,Vanessa L. Bryant,Vanessa L. Bryant,Philip D. Hodgkin,Philip D. Hodgkin,John Silke,John Silke,Gordon K. Smyth,Martijn A. Nolte,Wei Shi,Axel Kallies,Axel Kallies +29 more
TL;DR: It is shown that tumor necrosis factor receptor superfamily (TNFRSF) signaling plays a crucial role in the development and maintenance of eTreg cells and mutations in the RelA binding partner NF-κB1 compromised eT Reg cells in humans, suggesting that the TNFRSf-NF-κb axis was required in a non-redundant manner to maintain eTReg cells in mice and humans.
Journal ArticleDOI
SIDT2 Transports Extracellular dsRNA into the Cytoplasm for Innate Immune Recognition
Tan A. Nguyen,Tan A. Nguyen,Blake R. C. Smith,Michelle D. Tate,Michelle D. Tate,Gabrielle T. Belz,Gabrielle T. Belz,Marilou H. Barrios,Marilou H. Barrios,Kirstin Elgass,Alexandra S. Weisman,Paul J. Baker,Paul J. Baker,Simon Preston,Simon Preston,Lachlan Whitehead,Lachlan Whitehead,Alexandra L. Garnham,Alexandra L. Garnham,Rachel J. Lundie,Rachel J. Lundie,Gordon K. Smyth,Gordon K. Smyth,Marc Pellegrini,Marc Pellegrini,Meredith O'Keeffe,Meredith O'Keeffe,Ian P. Wicks,Ian P. Wicks,Seth L. Masters,Seth L. Masters,Craig P. Hunter,Ken C Pang +32 more
TL;DR: It is shown that the mammalian SID-1 ortholog, SIDT2, is required to transport internalized extracellular dsRNA from endocytic compartments into the cytoplasm for immune activation, and this transport is important for antiviral immunity.