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Alexandre Belisle
Researcher at McGill University
Publications - 15
Citations - 4101
Alexandre Belisle is an academic researcher from McGill University. The author has contributed to research in topics: DNA methylation & Type 2 diabetes. The author has an hindex of 9, co-authored 13 publications receiving 3878 citations.
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Journal ArticleDOI
A genome-wide association study identifies novel risk loci for type 2 diabetes
Robert Sladek,Ghislain Rocheleau,Johan Rung,Christian Dina,Lishuang Shen,David Serre,Philippe Boutin,Daniel Vincent,Alexandre Belisle,Samy Hadjadj,Beverley Balkau,Barbara Heude,Guillaume Charpentier,Thomas J. Hudson,Thomas J. Hudson,Alexandre Montpetit,Alexey V. Pshezhetsky,Marc Prentki,Barry I. Posner,David J. Balding,David Meyre,Constantin Polychronakos,Philippe Froguel,Philippe Froguel +23 more
TL;DR: Four loci containing variants that confer type 2 diabetes risk are identified and constitute proof of principle for the genome-wide approach to the elucidation of complex genetic traits.
Journal ArticleDOI
Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.
Johan Rung,Stéphane Cauchi,Anders Albrechtsen,Lishuang Shen,Lishuang Shen,Ghislain Rocheleau,Ghislain Rocheleau,Christine Cavalcanti-Proença,Francois Bacot,Beverley Balkau,Alexandre Belisle,Knut Borch-Johnsen,Guillaume Charpentier,Christian Dina,Emmanuelle Durand,Paul Elliott,Samy Hadjadj,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Jaana Laitinen,Torsten Lauritzen,Michel Marre,Alexander Mazur,David Meyre,Alexandre Montpetit,Charlotta Pisinger,Barry I. Posner,Pernille Poulsen,Anneli Pouta,Anneli Pouta,Marc Prentki,Rasmus Ribel-Madsen,Aimo Ruokonen,A. Sandbaek,David Serre,David Serre,Jean Tichet,Martine Vaxillaire,Jørgen F. P. Wojtaszewski,Allan Vaag,Allan Vaag,Torben Hansen,Torben Hansen,Constantin Polychronakos,Oluf Pedersen,Oluf Pedersen,Philippe Froguel,Philippe Froguel,Robert Sladek +48 more
TL;DR: The C allele of rs2943641 was associated with insulin resistance and hyperinsulinemia in 14,358 French, Danish and Finnish participants from population-based cohorts; this allele was also associated with reduced basal levels of IRS1 protein and decreased insulin induction of IRS 1-associated phosphatidylinositol-3-OH kinase activity in human skeletal muscle biopsies.
Journal ArticleDOI
Genetic variants of FTO influence adiposity, insulin sensitivity, leptin levels, and resting metabolic rate in the Quebec Family Study.
Ron Do,Swneke D. Bailey,Katia Desbiens,Alexandre Belisle,Alexandre Montpetit,Claude Bouchard,Louis Pérusse,Marie-Claude Vohl,James C. Engert +8 more
TL;DR: It is confirmed that genetic variation at the FTO locus contributes to the etiology of obesity, insulin resistance, and increased plasma leptin levels, as well as several obesity-related phenotypes.
Journal ArticleDOI
Genetic risk factors for post-infectious irritable bowel syndrome following a waterborne outbreak of gastroenteritis.
Alexandra-Chloé Villani,Mathieu Lemire,Marroon Thabane,Alexandre Belisle,Geneviève Geneau,Amit X. Garg,William F. Clark,Paul Moayyedi,Stephen M. Collins,Denis Franchimont,Denis Franchimont,John Marshall +11 more
TL;DR: Genes that encode proteins involved in epithelial cell barrier function and the innate immune response to enteric bacteria are associated with development of IBS following acute gastroenteritis, and four variants were associated with PI-IBS.
Journal ArticleDOI
LINE-1 methylation in visceral adipose tissue of severely obese individuals is associated with metabolic syndrome status and related phenotypes.
Valérie Turcot,André Tchernof,Yves Deshaies,Louis Pérusse,Alexandre Belisle,Simon Marceau,Simon Biron,Odette Lescelleur,Laurent Biertho,Marie-Claude Vohl +9 more
TL;DR: Results suggest that lower global DNA methylation, assessed by LINE-1 repetitive elements methylation analysis, would be associated with a greater risk for MetS in the presence of obesity.