P
Philippe Boutin
Researcher at Pasteur Institute
Publications - 44
Citations - 7294
Philippe Boutin is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Single-nucleotide polymorphism & Population. The author has an hindex of 30, co-authored 44 publications receiving 7066 citations. Previous affiliations of Philippe Boutin include Pasteur Institute of Lille & Centre national de la recherche scientifique.
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Journal ArticleDOI
A genome-wide association study identifies novel risk loci for type 2 diabetes
Robert Sladek,Ghislain Rocheleau,Johan Rung,Christian Dina,Lishuang Shen,David Serre,Philippe Boutin,Daniel Vincent,Alexandre Belisle,Samy Hadjadj,Beverley Balkau,Barbara Heude,Guillaume Charpentier,Thomas J. Hudson,Thomas J. Hudson,Alexandre Montpetit,Alexey V. Pshezhetsky,Marc Prentki,Barry I. Posner,David J. Balding,David Meyre,Constantin Polychronakos,Philippe Froguel,Philippe Froguel +23 more
TL;DR: Four loci containing variants that confer type 2 diabetes risk are identified and constitute proof of principle for the genome-wide approach to the elucidation of complex genetic traits.
Journal ArticleDOI
Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the japanese population
Kazuo Hara,Philippe Boutin,Yasumichi Mori,Kazuyuki Tobe,Christian Dina,Kazuki Yasuda,Toshimasa Yamauchi,Shuichi Otabe,Terumasa Okada,Kazuhiro Eto,Hiroko Kadowaki,Ryoko Hagura,Yasuo Akanuma,Yoshio Yazaki,Ryozo Nagai,Matsuo Taniyama,Koichi Matsubara,Madoka Yoda,Yasuko Nakano,Satoshi Kimura,Motowo Tomita,Chikako Ito,Philippe Froguel,Takashi Kadowaki +23 more
TL;DR: Evidence of an association between frequent single nucleotide polymorphisms at positions 45 and 276 in the adiponectin gene and type 2 diabetes is presented, and the observation that adiponECTin improves insulin sensitivity in animal models is concluded.
Journal ArticleDOI
Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians
Francis Vasseur,Nicole Helbecque,Christian Dina,Stéphane Lobbens,Valérie Delannoy,Stéphane Gaget,Philippe Boutin,Martine Vaxillaire,Frédéric Leprêtre,Sophie Dupont,Kazuo Hara,Karine Clément,Bernard Bihain,Takashi Kadowaki,Philippe Froguel +14 more
TL;DR: The results suggest that an at-risk haplotype of common variants located in the promoter and rare mutations in exon 3 contribute to the variation of the adipocyte-secreted adiponectin hormone level, and may be part of the genetic determinants for T2D in the French Caucasian population.
Journal ArticleDOI
Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes
David Meyre,David Meyre,Nabila Bouatia-Naji,Agnès Tounian,Chantal Samson,Cecile Lecoeur,Cecile Lecoeur,Vincent Vatin,Maya Ghoussaini,Christophe Wachter,Serge Hercberg,Guillaume Charpentier,Wolfgang Patsch,François Pattou,Marie-Aline Charles,Patrick Tounian,Karine Clément,Béatrice Jouret,Jacques Weill,Betty A. Maddux,Ira D. Goldfine,Andrew Walley,Philippe Boutin,Christian Dina,Philippe Froguel,Philippe Froguel +25 more
TL;DR: Findings suggest that several variants of ENPP1 have a primary role in mediating insulin resistance and in the development of both obesity and T2D, suggesting that an underlying molecular mechanism is common to both conditions.
Journal ArticleDOI
Common nonsynonymous variants in PCSK1 confer risk of obesity
Michael Benzinou,John W.M. Creemers,Hélène Choquet,Stéphane Lobbens,Christian Dina,Emmanuelle Durand,Audrey Guérardel,Philippe Boutin,Béatrice Jouret,Barbara Heude,Beverley Balkau,Jean Tichet,Michel Marre,Michel Marre,Natascha Potoczna,Fritz F. Horber,Catherine Le Stunff,Sébastien Czernichow,Annelli Sandbæk,Torsten Lauritzen,Knut Borch-Johnsen,Knut Borch-Johnsen,Gitte Andersen,Wieland Kiess,Antje Körner,Peter Kovacs,Peter Jacobson,Lena M. S. Carlsson,Andrew Walley,Torben Jørgensen,Torben Hansen,Oluf Pedersen,Oluf Pedersen,David Meyre,Philippe Froguel,Philippe Froguel +35 more
TL;DR: Functional analysis showed a significant impairment of the N221D-mutant PC1/3 protein catalytic activity, and genotyped tag SNPs were consistently associated with obesity in adults and children.