Alisa M. Goldstein

TL;DR: The clinical data reliably identify individuals likely to carry a dominantly inherited gene conferring susceptibility to a specific constellation of neoplasms and have implications for ultimately defining the component tumors of the Li-Fraumeni cancer family syndrome and for the causes and prevention of those tumors arising outside these families.

TL;DR: The presence of multiple primary melanomas but without family histories of the disease have germ-line mutations of the CDKN2A gene, which may signal a genetic susceptibility to melanoma not only in the index patient but also in family members, who may benefit from melanoma-surveillance programs.

TL;DR: Using high-resolution array-CGH, unique duplications of a region on 6q27 in four multiplex families with at least three cases of chordoma are identified, highlighting the value of screening for complex genomic rearrangements in searches for cancer-susceptibility genes.

TL;DR: A joint analysis showed that drinkers with both of the ADH1B and ALDH2 risk alleles had a fourfold increased risk for ESCC compared to drinkers without these risk allels, which underscores the direct genetic contribution to ESCC risk, as well as the genetic contribution through interaction with alcohol consumption.

TL;DR: Exposure to wood exposure during childhood, exposure to wood, and betel nut consumption were all associated with elevated NPC risk using conditional logistic regression, although these associations were not as strong as in the case-control study possibly due to shared environment among family members.