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Alisa M. Goldstein
Researcher at National Institutes of Health
Publications - 309
Citations - 24663
Alisa M. Goldstein is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Cancer & Population. The author has an hindex of 72, co-authored 297 publications receiving 22773 citations. Previous affiliations of Alisa M. Goldstein include United States Department of Health and Human Services.
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Journal ArticleDOI
Characterization of T gene sequence variants and germline duplications in familial and sporadic chordoma
Michael J. Kelley,Michael J. Kelley,Jianxin Shi,Bari J. Ballew,Paula L. Hyland,Wen-Qing Li,Melissa Rotunno,David A. Alcorta,Norbert J. Liebsch,Jason Mitchell,Jason Mitchell,Sara Bass,Sara Bass,David Roberson,David Roberson,Joseph Boland,Joseph Boland,Michael Cullen,Michael Cullen,Ji He,Ji He,Laurie Burdette,Laurie Burdette,Meredith Yeager,Meredith Yeager,Stephen J. Chanock,Dilys M. Parry,Alisa M. Goldstein,Xiaohong R. Yang +28 more
TL;DR: The sequenced T exons in 24 familial cases and 54 unaffected family members from eight chordoma families, three with T duplications, 103 sporadic cases, and 160 unrelated controls found three rare variants that were only observed among sporadic chordoma cases, all of which have potential functional relevance based on in silico predictions.
Journal ArticleDOI
Genome-wide loss of heterozygosity and copy number alteration in esophageal squamous cell carcinoma using the Affymetrix GeneChip Mapping 10 K array
Nan Hu,Chaoyu Wang,Ying Hu,Howard H. Yang,Li Hui Kong,Ning Lu,Hua Su,Quan Hong Wang,Alisa M. Goldstein,Kenneth H. Buetow,Michael R. Emmert-Buck,Philip R. Taylor,Maxwell P. Lee +12 more
TL;DR: These studies demonstrate that the Affymetrix 10 K SNP chip is a valid platform to integrate analyses of LOH and CNA, and will enable improved strategies to prevent, diagnose, and treat ESCC.
Journal ArticleDOI
Affected members of melanoma-prone families with linkage to 9p21 but lacking mutations in CDKN2A do not harbor mutations in the coding regions of either CDKN2B or p19ARF.
Ling Liu,Alisa M. Goldstein,Margaret A. Tucker,Herbert Brill,Nelleke A. Gruis,David Hogg,Norman J. Lassam +6 more
TL;DR: This study examined whether two other potential tumor suppressors, CDKN2B and p19ARF, play a role in the development of familial melanoma, and found no mutations in the coding regions of either gene in melanoma‐prone families with evidence of linkage to 9p21.
Journal ArticleDOI
Genetic susceptibility in familial melanoma from northeastern Italy
Maria Teresa Landi,Alisa M. Goldstein,S Tsang,David J. Munroe,William S. Modi,M Ter-Minassian,R Steighner,Michael Dean,N Metheny,B Staats,Ron Agatep,David W. Hogg,Donato Calista +12 more
TL;DR: Families prone to melanoma from northeastern Italy are studied to characterise genetic susceptibility to melanomas in this population, and a relatively high frequency of CDKN2A mutations is found.
Journal ArticleDOI
Cutaneous phenotype and MC1R variants as modifying factors for the development of melanoma in CDKN2A G101W mutation carriers from 4 countries.
Alisa M. Goldstein,Valérie Chaudru,Paola Ghiorzo,Celia Badenas,Josep Malvehy,Lorenza Pastorino,Karine Laud,Benjamin J. Hulley,Marie-Françoise Avril,Joan Anton Puig-Butille,Annie Miniere,Rosa M. Martí,Agnès Chompret,Francisco Cuellar,Isabel Kolm,Montserrat Milà,Margaret A. Tucker,Florence Demenais,Giovanna Bianchi-Scarrà,Susana Puig,Brigitte Bressac De-Paillerets +20 more
TL;DR: Variation in the effects of the cutaneous phenotypic and MC1R factors across the study sample suggests that these factors differentially contribute to development of melanoma even on a common genetic background of a germline CDKN2A mutation.