A
Ann M. Graybiel
Researcher at McGovern Institute for Brain Research
Publications - 360
Citations - 53036
Ann M. Graybiel is an academic researcher from McGovern Institute for Brain Research. The author has contributed to research in topics: Striatum & Basal ganglia. The author has an hindex of 121, co-authored 350 publications receiving 49771 citations. Previous affiliations of Ann M. Graybiel include Case Western Reserve University & Tufts University.
Papers
More filters
Proceedings ArticleDOI
Chronic multi-modal monitoring of neural activity in rodents and primates
Helen N. Schwerdt,Daniel J. Gibson,Ken-ichi Amemori,Lauren L. Stanwicks,Tomoko Yoshida,Michael J. Cima,Ann M. Graybiel +6 more
TL;DR: Multi-modal systems comprising implantable carbon fiber (CF)-based electrodes to record synchronously chemical and electrical forms of activity in the brain were used to examine the relationship between dopamine and beta-band LFPs, prominent biomarkers of untreated Parkinson’s disease.
Posted ContentDOI
Microstimulation of primate neocortex targeting striosomes induces negative decision-making
Satoko Amemori,Ken-ichi Amemori,Tomoko Yoshida,Georgios K. Papageorgiou,Rui Xu,Hideki Shimazu,Robert Desimone,Ann M. Graybiel +7 more
TL;DR: It is demonstrated that circumscribed pACC and cOFC microstimulation sites that induce negative decision-making preferentially project to striosomes in the anterior striatum.
Journal ArticleDOI
Spatiotemporal Up-Regulation of Mu Opioid Receptor 1 in Striatum of Mouse Model of Huntington's Disease Differentially Affecting Caudal and Striosomal Regions.
Ryoma Morigaki,Jannifer H. Lee,Tomoko Yoshida,Tomoko Yoshida,Christian Wüthrich,Christian Wüthrich,Dan Hu,Dan Hu,Jill R. Crittenden,Jill R. Crittenden,Alexander Friedman,Alexander Friedman,Yasuo Kubota,Yasuo Kubota,Ann M. Graybiel,Ann M. Graybiel +15 more
TL;DR: It is demonstrated that, contrary to the loss of many markers for striosomes, there is a pronounced up-regulation of MOR1 in these Q175 knock-in mice, and this MOR1 up- regulation progressed with advancing age and disease progression, and was particularly remarkable at caudal levels of the striatum.
Journal ArticleDOI
The Guanine-Nucleotide Exchange Factor Caldag Gefi Fine-Tunes Functional Properties of Regulatory T Cells.
Jana Niemz,Stefanie Kliche,Marina C. Pils,Eliot Morrison,Annika Manns,Christian Freund,Jill R. Crittenden,Ann M. Graybiel,Melanie Galla,Lothar Jänsch,Jochen Huehn +10 more
TL;DR: It is speculated that deficiency in CalDAG GEFI impairs adherence of Tregs to antigen-presenting cells, thereby impeding formation of a fully functional immunological synapse, which finally results in a reduced suppressive potential.