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Ann M. Graybiel
Researcher at McGovern Institute for Brain Research
Publications - 360
Citations - 53036
Ann M. Graybiel is an academic researcher from McGovern Institute for Brain Research. The author has contributed to research in topics: Striatum & Basal ganglia. The author has an hindex of 121, co-authored 350 publications receiving 49771 citations. Previous affiliations of Ann M. Graybiel include Case Western Reserve University & Tufts University.
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Guanine nucleotide exchange factors CalDAG-GEFI and CalDAG-GEFII are colocalized in striatal projection neurons.
TL;DR: It is suggested that the CalDAG‐GEFs may be key intracellular regulators whereby calcium and diacylglycerol signals can regulate cellular functions through small GTPases in the basal ganglia circuits.
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On somatic recombination in the central nervous system of transgenic mice
TL;DR: This work constructed a plasmid that contained the transcriptional promoter and enhancer of the mouse phosphoglycerate kinase-1 gene, a pair of RSSs derived from the Ig VK21C and JLI gene segments, and a reporter gene lacZ encoding bacterial P-galactosidase, and prepared a Tg V(D)J recombination substrate.
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Identification and localization of a neuron-specific isoform of TAF1 in rat brain: implications for neuropathology of DYT3 dystonia.
Wataru Sako,Ryoma Morigaki,Ryuji Kaji,Ikuo Tooyama,Shinya Okita,Keiko T. Kitazato,Shinji Nagahiro,Ann M. Graybiel,Satoshi Goto +8 more
TL;DR: In this article, a specific monoclonal antibody against the TAF1 protein was developed to determine the expression pattern of N-TAF1 transcripts in the rat brain.
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Approach-Avoidance Conflict in Major Depressive Disorder: Congruent Neural Findings in Humans and Nonhuman Primates
Maria Ironside,Ken-ichi Amemori,Callie L. McGrath,Mads Lund Pedersen,Min Su Kang,Satoko Amemori,Michael J. Frank,Ann M. Graybiel,Diego A. Pizzagalli,Diego A. Pizzagalli +9 more
TL;DR: There is conservation of anterior cingulate activation across species and that frontal and striatal regions, in unmedicated humans with MDD, are abnormally responsive during cost-benefit decision making.
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Pharmacologically defined M1 and M2 muscarinic cholinergic binding sites in the cat's substantia nigra: development and maturity
Mary A. Nastuk,Ann M. Graybiel +1 more
TL;DR: Findings provide further evidence that the substantia nigra is a site of cholinergic transmission and suggest that the functional balance between acetylcholine and dopamine in the basal ganglia acts here as well as in the striatum.