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Ann M. Graybiel
Researcher at McGovern Institute for Brain Research
Publications - 360
Citations - 53036
Ann M. Graybiel is an academic researcher from McGovern Institute for Brain Research. The author has contributed to research in topics: Striatum & Basal ganglia. The author has an hindex of 121, co-authored 350 publications receiving 49771 citations. Previous affiliations of Ann M. Graybiel include Case Western Reserve University & Tufts University.
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Journal ArticleDOI
Influence of mesostriatal afferents on the development and transmitter regulation of intrastriatal grafts derived from embryonic striatal primordia
TL;DR: The results suggest that TH-containing afferents from the host striatum, though not required for induction and maintenance of striatal phenotypy in striatal grafts, can chronically regulate neurotransmitter/neuromodulator expression in neurons of the striatum- like P zones in a manner similar to that found for the normal striatum.
Journal ArticleDOI
Striosomes Mediate Value-Based Learning Vulnerable in Age and a Huntington's Disease Model.
Alexander Friedman,Emily Hueske,Sabrina M. Drammis,Sebastian E. Toro Arana,Erik D. Nelson,Cody W. Carter,Sebastien Delcasso,Raimundo X. Rodriguez,Hope Lutwak,Kaden S. DiMarco,Qingyang Zhang,Lara I. Rakocevic,Dan Hu,Joshua K. Xiong,Jiajia Zhao,Leif G. Gibb,Tomoko Yoshida,Cody A. Siciliano,Thomas J. Diefenbach,Charu Ramakrishnan,Karl Deisseroth,Ann M. Graybiel +21 more
TL;DR: It is found that circuit connectivity and function of thestriosome compartment of the striatum are critical for valence-based learning, and that FSIs can modulate the striosomal signal-to-noise ratio, crucial for discrimination and learning.
Journal ArticleDOI
Dynamic ordering of early generated striatal cells destined to form the striosomal compartment of the striatum
TL;DR: In this article, pulse-labeled striosomal cells (S cells) and matrix cells (M cells) in cats with (3) H-thymidine were followed during fetal and postnatal development.
Book ChapterDOI
Role of Basal Ganglia in Sensory Motor Association Learning
Minoru Kimura,Ann M. Graybiel +1 more
TL;DR: A hypothetical scheme of basal ganglia functioning in behavioral learning is presented andLimbic input conveys information related to “reinforcement” or “incentive” either directly to the striatum or indirectly through nigrostriatal dopamine system, and it contributes to acquisition of taskrelated activity and expression of the acquired activity in the Striatum.
Journal ArticleDOI
Tectorecipient zone of cat lateral posterior nucleus: evidence that collicular afferents contain acetylcholinesterase.
David M. Berson,Ann M. Graybiel +1 more
TL;DR: Results are consistent with the view that LP-projecting collicular neurons synthesize AChE and account for much of the histochemically detectable enzyme present both in the lower superficial gray layer and in LPm.