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Ann M. Graybiel
Researcher at McGovern Institute for Brain Research
Publications - 360
Citations - 53036
Ann M. Graybiel is an academic researcher from McGovern Institute for Brain Research. The author has contributed to research in topics: Striatum & Basal ganglia. The author has an hindex of 121, co-authored 350 publications receiving 49771 citations. Previous affiliations of Ann M. Graybiel include Case Western Reserve University & Tufts University.
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Basal ganglia: New therapeutic approaches to Parkinson's disease
TL;DR: This data indicates that preoperatively manipulating basal ganglia during surgery is a viable treatment option for Parkinson's disease and may even be beneficial in the absence of other treatments.
Journal Article
Cell-type Specific Optogenetic Mice for Dissecting Neural Circuitry Function
Shengli Zhao,Jonathan T. Ting,Hicham Atallah,Li Qiu,Jie Tan,Bernd Gloss,George J Augustine,Karl Deisseroth,Minmin Luo,Ann M. Graybiel,Guoping Feng +10 more
TL;DR: A Bacterial Artificial Chromosome (BAC) transgenic strategy to express Channelrhodopsin2 (ChR2) under the control of cell-type specific promoter elements will facilitate the precise mapping of neuronal connectivity and the dissection of the neural basis of behavior.
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Learning new sequential stepping patterns requires striatal plasticity during the earliest phase of acquisition.
Toru Nakamura,Toru Nakamura,Masatoshi Nagata,Takeshi Yagi,Ann M. Graybiel,Tetsuo Yamamori,Tetsuo Yamamori,Takashi Kitsukawa,Takashi Kitsukawa,Takashi Kitsukawa +9 more
TL;DR: The findings suggest that the dorsolateral striatum is activated on detecting shifts in environment to adapt motor behavior to the new context via NMDA‐dependent plasticity, and that this plasticity may underlie forming and breaking skills and habits as well as to behavioral difficulties in clinical disorders.
Journal ArticleDOI
Dopamine and beta-band oscillations differentially link to striatal value and motor control.
Helen N. Schwerdt,Helen N. Schwerdt,Ken-ichi Amemori,Daniel J. Gibson,Lauren L. Stanwicks,Tomoko Yoshida,Narcisse P. Bichot,Satoko Amemori,Robert Desimone,Robert Langer,Michael J. Cima,Ann M. Graybiel +11 more
TL;DR: Measurements demonstrated that task-elicited beta suppressions preceded dopamine peaks and that relative dopamine-beta timing and polarity depended on reward value, performance history, movement, and striatal domain, establishing a new view of coordinate dopamine and beta signaling operations.
Dynamic ordering of early generated striatal cells destined to form the striosomal compartment of the striatum
TL;DR: It is suggested that the maturational histories of the striosomal and matrix neurons are influenced by their generation times and local environments, and that future S cells have transient, nonstriosomal distributions prior to their aggregation into Striosomal clusters, including a putative waiting compartment.