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Ann M. Graybiel
Researcher at McGovern Institute for Brain Research
Publications - 360
Citations - 53036
Ann M. Graybiel is an academic researcher from McGovern Institute for Brain Research. The author has contributed to research in topics: Striatum & Basal ganglia. The author has an hindex of 121, co-authored 350 publications receiving 49771 citations. Previous affiliations of Ann M. Graybiel include Case Western Reserve University & Tufts University.
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Book ChapterDOI
Cholinergic Systems in Alzheimer’s Disease, Parkinson’s Disease and Progressive Supranuclear Palsy
Yves Agid,Ann M. Graybiel,Merle Ruberg,Etienne C. Hirsch,Jean-Philippe Brandel,Pascale Cervera,Jorge L. Juncos,Stéphane Lehéricy,Susanne Malessa,G. Ransmayr +9 more
TL;DR: It is now possible to visualize cholinerigc cell bodies, fibers and varicosites with immunocytochemical techniques using antibodies directed specifically against human ChAT, and this type data can be quantified by computerized image analysis.
Journal ArticleDOI
Predominant Striatal Input to the Lateral Habenula in Macaques Comes from Striosomes
TL;DR: In this article, a method to identify striosomes on-line in awake, behaving macaques was introduced, which combined electrical microstimulation of the striatum with simultaneous electrophysiological recording in the lateral habenula (LHb) followed by immunohistochemistry.
Journal Article
Early-stage loss of dopamine uptake-site binding in MPTP-treated monkeys.
Journal ArticleDOI
5'-nucleotidase: a new marker for striosomal organization in the rat caudoputamen.
TL;DR: It is concluded that 5′‐nucleotidase histochemistry provides an advantageous tool for detecting the striosomal architecture of the rat's caudoputamen and may contribute to the specialized functions of striosomes and matrix.
Journal ArticleDOI
Combinatorial Developmental Controls on Striatonigral Circuits
Ayano Matsushima,Ann M. Graybiel +1 more
TL;DR: This work maps one set of SPNs, those in striosomes, with striatonigral projections to the dopamine-containing substantia nigra pars compacta (SNpc) and highlights a logic intercalating birth date-dependent andBirth date-independent factors in determining the trajectories of SPN axons and organizing specialized units of striatonIGral circuitry that could influence behavioral expression and vulnerabilities to disease.