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Ann M. Graybiel
Researcher at McGovern Institute for Brain Research
Publications - 360
Citations - 53036
Ann M. Graybiel is an academic researcher from McGovern Institute for Brain Research. The author has contributed to research in topics: Striatum & Basal ganglia. The author has an hindex of 121, co-authored 350 publications receiving 49771 citations. Previous affiliations of Ann M. Graybiel include Case Western Reserve University & Tufts University.
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Journal ArticleDOI
Activity of striatal neurons reflects dynamic encoding and recoding of procedural memories
TL;DR: It is proposed that changes in task representation in cortico-basal ganglia circuits represent neural equivalents of the explore–exploit behaviour characteristic of habit learning.
Journal ArticleDOI
Building action repertoires: memory and learning functions of the basal ganglia.
TL;DR: Experimental findings on reward-based learning suggest that neural activity in the striatum and substantia nigra, pars compacta changes during behavioral learning, and new evidence also suggests extreme specificity in the neural connections interrelating the basal ganglia, cerebral cortex and thalamus.
Journal ArticleDOI
Cell type-specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function
Shengli Zhao,Jonathan T. Ting,Jonathan T. Ting,Hisham E Atallah,Li Qiu,Jie Tan,Bernd Gloss,George J. Augustine,George J. Augustine,George J. Augustine,Karl Deisseroth,Minmin Luo,Ann M. Graybiel,Guoping Feng,Guoping Feng +14 more
TL;DR: In this paper, the authors used a bacterial artificial chromosome (BAC) transgenic strategy to express the H134R variant of channelrhodopsin-2, ChR2(H134R), under the control of cell type-specific promoter elements.
Journal ArticleDOI
Responses of tonically active neurons in the primate's striatum undergo systematic changes during behavioral sensorimotor conditioning
Toshihiko Aosaki,Hiroshi Tsubokawa,Akihiro Ishida,Katsushige Watanabe,Ann M. Graybiel,Minoru Kimura +5 more
TL;DR: It is concluded that, during the acquisition of a sensorimotor association, TANs widely distributed through the striatum become responsive to sensory stimuli that induce conditioned behavior.
Cell type–specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function
Shengli Zhao,Jonathan T. Ting,Jonathan T. Ting,Hisham E Atallah,Li Qiu,Jie Tan,Bernd Gloss,George J. Augustine,George J. Augustine,George J. Augustine,Karl Deisseroth,Minmin Luo,Ann M. Graybiel,Guoping Feng,Guoping Feng +14 more
TL;DR: This resource of cell type–specific ChR2(H134R) mouse lines will facilitate the precise mapping of neuronal connectivity and the dissection of the neural basis of behavior.