Ann M. Graybiel

TL;DR: Through genetic fate mapping, it is demonstrated that striosome-matrix compartmentalization arises from a lineage program embedded in lateral ganglionic eminence radial glial progenitors mediating neurogenesis through two distinct types of intermediate progenitor (IPs).

TL;DR: It is suggested that brain mechanisms underlying the emergence of habits, and perhaps unwanted repetitive behaviors in clinical disorders, could follow RL algorithms capturing extremely local explore/exploit tradeoffs.

TL;DR: The results suggest that compartmentalization of afferent and efferent processing by projection neurons in the primate striatum is not absolute, and for a subpopulation of spiny neurons in striosomes and matrix, inputs to one compartment could have a direct influence on output cells of the other.

TL;DR: Evidence is presented that during striatal ontogeny, both neurons and neuropil expressing CaM kinase II-like immunoreactivity and SV48-positive terminals form discrete patches that are in register with dopamine islands, suggesting a developmental sequence in which dopamine-containing fibers invade the striatal anlage prior to forming distinct islandic foci and prior to the maturational events signaled by the production of CaM Kinase II.

TL;DR: It is suggested that neurons of developing striosome and matrix compartments not only have different functional coupling of D1-like receptors to adenylate cyclase, but also have distinct maturational programs for dopaminergic regulation of individual transcription factors.