S
Shuichiro Nakabo
Researcher at National Institutes of Health
Publications - 34
Citations - 988
Shuichiro Nakabo is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Rheumatoid arthritis & Systemic lupus erythematosus. The author has an hindex of 10, co-authored 30 publications receiving 401 citations. Previous affiliations of Shuichiro Nakabo include Kyoto University.
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Journal ArticleDOI
Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease.
David B. Beck,Marcela A. Ferrada,Keith A. Sikora,Amanda K. Ombrello,Jason C. Collins,Wuhong Pei,Nicholas Balanda,Daron L. Ross,Daniela Ospina Cardona,Zhijie Wu,Bhavisha A Patel,Kalpana Manthiram,Emma M. Groarke,Fernanda Gutierrez-Rodrigues,Patrycja Hoffmann,Sofia Rosenzweig,Shuichiro Nakabo,Laura W. Dillon,Christopher S. Hourigan,Wanxia L. Tsai,Sarthak Gupta,Carmelo Carmona-Rivera,Anthony J. Asmar,Lisha Xu,Hirotsugu Oda,Wendy Goodspeed,Karyl S. Barron,Michele Nehrebecky,Anne Jones,Ryan S. Laird,Natalie Deuitch,Dorota Rowczenio,Emily Rominger,Kristina V. Wells,Chyi-Chia Richard Lee,Weixin Wang,Megan Trick,James C. Mullikin,Gustaf Wigerblad,Stephen R. Brooks,Stefania Dell'Orso,Zuoming Deng,Jae Jin Chae,Alina Dulau-Florea,May Christine V. Malicdan,Danica Novacic,Robert A. Colbert,Mariana J. Kaplan,Massimo Gadina,Sinisa Savic,Helen J. Lachmann,Mones Abu-Asab,Benjamin D. Solomon,Kyle Retterer,William A. Gahl,Shawn M. Burgess,Ivona Aksentijevich,Neal S. Young,Katherine R. Calvo,Achim Werner,Daniel L. Kastner,Peter C. Grayson +61 more
TL;DR: Using a genotype-driven approach, this disorder is identified that connects seemingly unrelated adult-onset inflammatory syndromes and is named the VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome.
Journal ArticleDOI
Transcriptomic, epigenetic, and functional analyses implicate neutrophil diversity in the pathogenesis of systemic lupus erythematosus.
Pragnesh Mistry,Shuichiro Nakabo,Liam J. O’Neil,Rishi R. Goel,Kan Jiang,Carmelo Carmona-Rivera,Sarthak Gupta,Diana Chan,Philip M. Carlucci,Xinghao Wang,Faiza Naz,Zerai Manna,Amit K. Dey,Nehal N. Mehta,Sarfaraz Hasni,Stefania Dell'Orso,Gustavo Gutierrez-Cruz,Hong-Wei Sun,Mariana J. Kaplan +18 more
TL;DR: Phenotypic, functional, and pathogenic neutrophil heterogeneity are prevalent in SLE and may promote immune dysregulation and prominent vascular damage characteristic of this disease.
Journal ArticleDOI
Sex differences in neutrophil biology modulate response to type I interferons and immunometabolism
Sarthak Gupta,Shuichiro Nakabo,Luz P. Blanco,Liam J. O’Neil,Gustaf Wigerblad,Rishi R. Goel,Pragnesh Mistry,Kan Jiang,Carmelo Carmona-Rivera,Diana Chan,Xinghao Wang,Hege Lynum Pedersen,Manasi Gadkari,Katherine N Howe,Faiza Naz,Stefania Dell'Orso,Sarfaraz Hasni,Caeden Dempsey,Ashley Buscetta,Pamela A. Frischmeyer-Guerrerio,Paul Kruszka,Maximilian Muenke,Luis M. Franco,Hong-Wei Sun,Mariana J. Kaplan +24 more
TL;DR: It is reported that healthy young adult females have an activated/mature neutrophil profile characterized by enhanced type I IFN pathway activity, enhanced proinflammatory responses, and distinct bioenergetics, and it is shown that these differences are cell specific and likely driven by sex hormones.
Journal ArticleDOI
Interferon lambda promotes immune dysregulation and tissue inflammation in TLR7-induced lupus.
Rishi R. Goel,Xinghao Wang,Liam J. O’Neil,Shuichiro Nakabo,Kowser Hasneen,Sarthak Gupta,Gustaf Wigerblad,Luz P. Blanco,Jeffrey B. Kopp,Maria I. Morasso,Sergei V. Kotenko,Zu-Xi Yu,Carmelo Carmona-Rivera,Mariana J. Kaplan +13 more
TL;DR: Evidence is presented that interferon lambda is pathogenic and has nonredundant functions in TLR7-associated lupus inflammation, and it is found that interFERon lambda promotes systemic immune dysregulation through localized effects in the skin and kidneys.
Journal ArticleDOI
Amino acid signatures of HLA Class-I and II molecules are strongly associated with SLE susceptibility and autoantibody production in Eastern Asians.
Julio E. Molineros,Loren L. Looger,Kwangwoo Kim,Yukinori Okada,Chikashi Terao,Chikashi Terao,Chikashi Terao,Celi Sun,Xu-jie Zhou,Prithvi Raj,Yuta Kochi,Akari Suzuki,Shuji Akizuki,Shuichiro Nakabo,So Young Bang,Hye Soon Lee,Young Mo Kang,Chang Hee Suh,Won Tae Chung,Yong Beom Park,Jung Yoon Choe,Seung Cheol Shim,Shin-Seok Lee,Xiaoxia Zuo,Kazuhiko Yamamoto,Quan Zhen Li,Nan Shen,Nan Shen,Nan Shen,Lauren L. Porter,John B. Harley,John B. Harley,John B. Harley,Kek Heng Chua,Hong Zhang,Edward K. Wakeland,Betty P. Tsao,Sang Cheol Bae,Swapan K. Nath +38 more
TL;DR: In insights about the mechanisms by which the risk residues interact with each other to produce autoantibodies and are involved in SLE pathophysiology, this work identified novel SLE signals in HLA Class I loci (HLA-A, HLA-B), and localized primary Class II signals to five residue-autoantibody association.