A
Anne Jörns
Researcher at Hannover Medical School
Publications - 98
Citations - 4026
Anne Jörns is an academic researcher from Hannover Medical School. The author has contributed to research in topics: Insulin & Beta cell. The author has an hindex of 29, co-authored 95 publications receiving 3598 citations.
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Journal ArticleDOI
Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities.
TL;DR: Cytokines and nutrients trigger beta-cell death by fundamentally different mechanisms, namely an NF-kappaB-dependent mechanism that culminates in caspase-3 activation for cytokines and anNF-kappB-independent mechanism for nutrients.
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Mitochondrial Catalase Overexpression Protects Insulin-Producing Cells Against Toxicity of Reactive Oxygen Species and Proinflammatory Cytokines
TL;DR: It can be concluded that targeted overexpression of catalase in the mitochondria provides particularly effective protection against cell death in all situations in which ROS are generated intramitochondrially.
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Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes
Michele Solimena,Michele Solimena,Anke M. Schulte,Lorella Marselli,Florian Ehehalt,Daniela Richter,Manuela Kleeberg,Hassan Mziaut,Klaus-Peter Knoch,Julia Parnis,Marco Bugliani,Afshan Siddiq,Afshan Siddiq,Anne Jörns,Frédéric Burdet,Robin Liechti,Mara Suleiman,Daniel Margerie,Farooq Syed,Marius Distler,Robert Grützmann,Enrico Petretto,Enrico Petretto,Aida Moreno-Moral,Aida Moreno-Moral,C. Wegbrod,Anke Sönmez,Katja Pfriem,A. Friedrich,Jörn Meinel,Claes B. Wollheim,Gustavo B. Baretton,Raphael Scharfmann,Everson Nogoceke,Ezio Bonifacio,Dorothée Sturm,Birgit Meyer-Puttlitz,Ugo Boggi,Hans-Detlev Saeger,Franco Filipponi,Mathias Lesche,Paolo Meda,Andreas Dahl,Leonore Wigger,Ioannis Xenarios,Mario Falchi,Bernard Thorens,Jürgen Weitz,Krister Bokvist,Sigurd Lenzen,Guy A. Rutter,Philippe Froguel,Manon von Bulow,Mark Ibberson,Piero Marchetti +54 more
TL;DR: These studies enabled the stringent definition of a novel transcriptomic signature of type 2 diabetic islets, regardless of islet source and isolation procedure, which indicates differences possibly due to peculiarities of these hyperglycaemic conditions.
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Norovirus Triggered Microbiota-driven Mucosal Inflammation in Interleukin 10-deficient Mice
Marijana Basic,Lydia M. Keubler,Manuela Buettner,Marcel Achard,Gerhard Breves,Bernd Schröder,Anna Smoczek,Anne Jörns,Dirk Wedekind,Nils H. Zschemisch,Claudia Günther,Detlef Neumann,Stefan Lienenklaus,Siegfried Weiss,Mathias W. Hornef,Michael Mähler,André Bleich +16 more
TL;DR: Despite its subclinical course in wild-type animals, MNV causes epithelial barrier disruption in Il10−/− animals representing a potent colitogenic stimulus that largely depends on the presence of the enteric microbiota.
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Immune Cell Infiltration, Cytokine Expression, and β-Cell Apoptosis During the Development of Type 1 Diabetes in the Spontaneously Diabetic LEW.1AR1/Ztm-iddm Rat
TL;DR: A sequence of pathological changes leading to apoptotic beta-cell death in the IDDM rat provides a mechanistic explanation for the development of the diabetic syndrome in this animal model of human type 1 diabetes.