Beth E. P. Henderson

TL;DR: Analysis of transcriptomes of more than 100,000 single human cells yields molecular definitions for non-parenchymal cell types that are found in healthy and cirrhotic human liver, and identifies markers for scar-associated macrophages and endothelial cells.

TL;DR: The power of single-cell transcriptomics is illustrated to resolve the key collagen-producing cells driving liver fibrosis with high precision, revealing spatial zonation of HSCs across the hepatic lobule.

TL;DR: A single-cell gene expression atlas of cardiac specific resident ECs, and the transcriptional hierarchy underpinning endogenous vascular repair following MI are presented, which provide a rich resource that could assist in the development of new therapeutic interventions to augment endogenous myocardial perfusion and enhance regeneration in the injured heart.

TL;DR: The omentum is a visceral adipose tissue rich in fat-associated lymphoid clusters (FALCs) that collects peritoneal contaminants and provides a first layer of immunological defense within the abdomen, and inhibition of protein arginine deiminase 4, an enzyme important for the release of neutrophils extracellular traps, abolished neutrophil aggregation and the capture of peritoneAL contaminants by omental FALCs.

TL;DR: Functional recovery mediated by the combination therapy is likely due to a superposition of de novo muscle fiber regeneration and augmented repair of muscle fibers within the remaining musculature, and the capacity for VML therapies to augment regeneration and repair within the remain musculatures may have significant clinical impact and warrants further exploration.