Taibo Li

TL;DR: It is illustrated that InWeb_InBioMap enables functional interpretation of >4,700 cancer genomes and genes involved in autism and better functional biological relevance than comparable resources.

TL;DR: While MS is most likely initially triggered by perturbation of peripheral immune responses the functional responses of microglia and other brain cells are also altered and may have a role in targeting an autoimmune process to the central nervous system.

TL;DR: A new method to identify the causal genes by integrating GWAS summary statistics with gene expression, biological pathway, and predicted protein-protein interaction data is introduced, demonstrating that a polygenic approach is a powerful tool for gene prioritization and, in combination with locus-specific signal, improves upon existing methods.

TL;DR: A study integrating single-cell RNA-sequencing and electrophysiology data shows that in mouse, the cellular repertoire of the thalamic reticular nucleus is characterized by a transcriptomic gradient defined at its extremes by mutually exclusive expression of Spp1 and Ecel1, providing insights into the organizational principles underlying the divergent functions of this brain region.

TL;DR: In this paper, the authors evaluated the efficacy of replacement gene therapy in a murine model of Leber congenital amaurosis (LCA) carrying a targeted disruption of RPGRIP1.