P
Patrick Sullivan
Researcher at University of North Carolina at Chapel Hill
Publications - 48
Citations - 2763
Patrick Sullivan is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Genome-wide association study & Indigenous. The author has an hindex of 17, co-authored 43 publications receiving 2029 citations. Previous affiliations of Patrick Sullivan include Karolinska Institutet & Australian Institute of Aboriginal and Torres Strait Islander Studies.
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Journal ArticleDOI
Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence
Jeanne E. Savage,Philip R. Jansen,Philip R. Jansen,Sven Stringer,Kyoko Watanabe,Julien Bryois,Christiaan de Leeuw,Mats Nagel,Swapnil Awasthi,Peter B. Barr,Jonathan R. I. Coleman,Katrina L. Grasby,Anke R. Hammerschlag,Jakob Kaminski,Robert Karlsson,Eva Krapohl,Max Lam,Marianne Nygaard,Chandra A. Reynolds,Joey W. Trampush,Hannah Young,Delilah Zabaneh,Sara Hägg,Narelle K. Hansell,Ida K. Karlsson,Sten Linnarsson,Grant W. Montgomery,Grant W. Montgomery,Ana B. Muñoz-Manchado,Erin Burke Quinlan,Gunter Schumann,Nathan G. Skene,Nathan G. Skene,Bradley T. Webb,Tonya White,Dan E. Arking,Dimitrios Avramopoulos,Robert M. Bilder,Panos Bitsios,Katherine E. Burdick,Katherine E. Burdick,Katherine E. Burdick,Tyrone D. Cannon,Ornit Chiba-Falek,Andrea Christoforou,Elizabeth T. Cirulli,Eliza Congdon,Aiden Corvin,Gail Davies,Ian J. Deary,Pamela DeRosse,Pamela DeRosse,Dwight Dickinson,Srdjan Djurovic,Srdjan Djurovic,Gary Donohoe,Emily Drabant Conley,Johan G. Eriksson,Thomas Espeseth,Nelson A. Freimer,Stella G. Giakoumaki,Ina Giegling,Michael Gill,David C. Glahn,Ahmad R. Hariri,Alex Hatzimanolis,Alex Hatzimanolis,Matthew C. Keller,Emma Knowles,Deborah C. Koltai,Bettina Konte,Jari Lahti,Stephanie Le Hellard,Todd Lencz,Todd Lencz,David C. Liewald,Edythe D. London,Astri J. Lundervold,Anil K. Malhotra,Anil K. Malhotra,Ingrid Melle,Ingrid Melle,Derek W. Morris,Anna C. Need,William Ollier,Aarno Palotie,Aarno Palotie,Aarno Palotie,Antony Payton,Neil Pendleton,Russell A. Poldrack,Katri Räikkönen,Ivar Reinvang,Panos Roussos,Panos Roussos,Dan Rujescu,Fred W. Sabb,Matthew A. Scult,Olav B. Smeland,Nikolaos Smyrnis,Nikolaos Smyrnis,John M. Starr,Vidar M. Steen,Nikos C. Stefanis,Nikos C. Stefanis,Richard E. Straub,Kjetil Sundet,Henning Tiemeier,Aristotle N. Voineskos,Daniel R. Weinberger,Elisabeth Widen,Jin Yu,Gonçalo R. Abecasis,Ole A. Andreassen,Gerome Breen,Lene Christiansen,Birgit Debrabant,Danielle M. Dick,Andreas Heinz,Jens Hjerling-Leffler,M. Arfan Ikram,Kenneth S. Kendler,Nicholas G. Martin,Sarah E. Medland,Nancy L. Pedersen,Robert Plomin,Tinca J. C. Polderman,Stephan Ripke,Stephan Ripke,Stephan Ripke,Sophie van der Sluis,Patrick Sullivan,Patrick Sullivan,Scott I. Vrieze,Margaret J. Wright,Danielle Posthuma +135 more
TL;DR: A large-scale genetic association study of intelligence identifies 190 new loci and implicates 939 new genes related to neurogenesis, neuron differentiation and synaptic structure, a major step forward in understanding the neurobiology of cognitive function as well as genetically related neurological and psychiatric disorders.
Journal ArticleDOI
Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways
David M. Howard,Mark Adams,Masoud Shirali,Toni-Kim Clarke,Riccardo E. Marioni,Gail Davies,Jonathan R. I. Coleman,Jonathan R. I. Coleman,Clara Alloza,Xueyi Shen,Miruna C. Barbu,Eleanor M. Wigmore,Jude Gibson,Saskia P. Hagenaars,Saskia P. Hagenaars,Cathryn M. Lewis,Cathryn M. Lewis,Joey Ward,Daniel J. Smith,Patrick Sullivan,Patrick Sullivan,Chris Haley,Gerome Breen,Gerome Breen,Ian J. Deary,Andrew M. McIntosh +25 more
TL;DR: It is suggested that broad depression is the most tractable UK Biobank phenotype for discovering genes and gene sets that further the understanding of the biological pathways underlying depression.
Journal ArticleDOI
Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders
Tarjinder Singh,Mitja I. Kurki,David Curtis,Shaun M. Purcell,Lucy Crooks,Jeremy F. McRae,Jaana Suvisaari,Himanshu Chheda,Douglas Blackwood,Gerome Breen,Olli Pietilainen,Sebastian S. Gerety,Muhammad Ayub,Moira Blyth,Trevor Cole,David Collier,Eve L. Coomber,Nicholas John Craddock,Mark J. Daly,John Danesh,Marta DiForti,Alison Foster,Nelson B. Freimer,Daniel H. Geschwind,Mandy Johnstone,Shelagh Joss,G. Kirov,Jarmo Körkkö,Outi Kuismin,Peter Holmans,Christina M. Hultman,Conrad Iyegbe,Jouko Lönnqvist,Minna Männikkö,Steve McCarroll,Peter McGuffin,Andrew M. McIntosh,Andrew McQuillin,Jukka S. Moilanen,Carmel Moore,Robin M. Murray,Ruth Newbury-Ecob,Willem H. Ouwehand,Tiina Paunio,Elena Prigmore,Elliott Rees,David J. Roberts,Jennifer G. Sambrook,Pamela Sklar,David St Clair,Juha Veijola,James T.R. Walters,Hywel Williams,Swedish Schizophrenia Study,Interval Study,Ddd Study,Patrick Sullivan,Matthew E. Hurles,Michael Conlon O'Donovan,Aarno Palotie,Michael J. Owen,Jeffrey C. Barrett +61 more
TL;DR: In this article, the authors found a genome-wide significant association between rare loss-of-function (LoF) variants in SETD1A and risk for schizophrenia (P = 3.3 × 10−9).
Journal ArticleDOI
Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia
Douglas M. Ruderfer,Ayman H. Fanous,Ayman H. Fanous,Ayman H. Fanous,Stephan Ripke,Stephan Ripke,Andrew McQuillin,Richard Amdur,Pablo V. Gejman,Michael Conlon O'Donovan,Ole A. Andreassen,Srdjan Djurovic,Christina M. Hultman,John R. Kelsoe,John R. Kelsoe,Stéphane Jamain,Stéphane Jamain,Mikael Landén,Mikael Landén,Marion Leboyer,Marion Leboyer,Vishwajit L. Nimgaonkar,John I. Nurnberger,Jordan W. Smoller,Nicholas John Craddock,Aiden Corvin,Patrick Sullivan,Peter Holmans,Pamela Sklar,Kenneth S. Kendler +29 more
TL;DR: A combined genome-wide association study of bipolar disorder and schizophrenia cases versus controls and a direct comparison GWAS of SCZ cases indicates that combining diseases with similar genetic risk profiles improves power to detect shared risk loci and that future direct comparisons of BP and SCZ are likely to identify loci with significant differential effects.
Journal ArticleDOI
Quantifying the Impact of Rare and Ultra-rare Coding Variation across the Phenotypic Spectrum
Andrea Ganna,F. Kyle Satterstrom,F. Kyle Satterstrom,Seyedeh M. Zekavat,Seyedeh M. Zekavat,Indraniel Das,Indraniel Das,Mitja I. Kurki,Mitja I. Kurki,Mitja I. Kurki,Claire Churchhouse,Claire Churchhouse,Jessica Alföldi,Jessica Alföldi,Alicia R. Martin,Alicia R. Martin,Aki S. Havulinna,Aki S. Havulinna,Andrea Byrnes,Andrea Byrnes,Wesley K. Thompson,Philip R. Nielsen,Philip R. Nielsen,Konrad J. Karczewski,Konrad J. Karczewski,Elmo Saarentaus,Manuel A. Rivas,Namrata Gupta,Olli Pietilainen,Olli Pietilainen,Connor A. Emdin,Francesco Lescai,Francesco Lescai,Jonas Bybjerg-Grauholm,Jonas Bybjerg-Grauholm,Jason Flannick,Jason Flannick,Josep M. Mercader,Josep M. Mercader,Miriam S. Udler,Miriam S. Udler,Markku Laakso,Veikko Salomaa,Christina M. Hultman,Samuli Ripatti,Samuli Ripatti,Eija Hämäläinen,Jukka S. Moilanen,Jarmo Körkkö,Outi Kuismin,Merete Nordentoft,Merete Nordentoft,David M. Hougaard,David M. Hougaard,Ole Mors,Ole Mors,Thomas Werge,Thomas Werge,Thomas Werge,Preben Bo Mortensen,Daniel G. MacArthur,Daniel G. MacArthur,Mark J. Daly,Mark J. Daly,Patrick Sullivan,Patrick Sullivan,Adam E. Locke,Adam E. Locke,Aarno Palotie,Anders D. Børglum,Anders D. Børglum,Sekar Kathiresan,Sekar Kathiresan,Benjamin M. Neale,Benjamin M. Neale +74 more
TL;DR: A thorough investigation of the impact of rare deleterious coding variants on complex traits, suggesting widespread pleiotropic risk is provided.