A
Alke Meents
Researcher at University of Hamburg
Publications - 82
Citations - 2699
Alke Meents is an academic researcher from University of Hamburg. The author has contributed to research in topics: Femtosecond & Protein crystallization. The author has an hindex of 27, co-authored 73 publications receiving 2137 citations. Previous affiliations of Alke Meents include Paul Scherrer Institute.
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Journal ArticleDOI
Room-temperature macromolecular serial crystallography using synchrotron radiation.
Francesco Stellato,Dominik Oberthür,Mengning Liang,Richard Bean,Cornelius Gati,Oleksandr Yefanov,Anton Barty,Anja Burkhardt,Pontus Fischer,Lorenzo Galli,Richard A. Kirian,Jan Meyer,Saravanan Panneerselvam,Chun Hong Yoon,Fedor Chervinskii,Emily M. Speller,Thomas A. White,Christian Betzel,Alke Meents,Henry N. Chapman +19 more
TL;DR: The room-temperature structure of lysozyme is determined using 40000 individual diffraction patterns from micro-crystals flowing in liquid suspension across a synchrotron microfocus beamline.
Journal ArticleDOI
X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease.
Sebastian Günther,P. Reinke,Yaiza Fernández-García,J. Lieske,Thomas J. Lane,Helen M. Ginn,Faisal Hammad Mekky Koua,Christiane Ehrt,W. Ewert,Dominik Oberthuer,Oleksandr Yefanov,S. Meier,Kristina Lorenzen,Boris Krichel,Janine-Denise Kopicki,Luca Gelisio,W. Brehm,Ilona Dunkel,B. Seychell,Henry Gieseler,Brenna Norton-Baker,Brenna Norton-Baker,Beatriz Escudero-Pérez,M. Domaracky,S. Saouane,A. Tolstikova,Thomas A. White,Anna Hänle,M. Groessler,Holger Fleckenstein,F. Trost,M. Galchenkova,Y. Gevorkov,Chufeng Li,Salah Awel,Ariana Peck,Miriam Barthelmess,Frank Schlünzen,P. Lourdu Xavier,N. Werner,H. Andaleeb,N. Ullah,Sven Falke,Vasundara Srinivasan,Bruno Alves Franca,M. Schwinzer,Hévila Brognaro,Cromarte Rogers,D. Melo,Joanna J. Zaitseva-Doyle,Juraj Knoska,Gisel E. Peña-Murillo,Aida Rahmani Mashhour,V. Hennicke,Pontus Fischer,Johanna Hakanpää,Jan Meyer,Philip Gribbon,Bernhard Ellinger,Maria Kuzikov,Markus Wolf,Andrea R. Beccari,Gleb Bourenkov,David von Stetten,Guillaume Pompidor,Isabel Bento,Saravanan Panneerselvam,Ivars Karpics,Thomas R. Schneider,Maria Garcia-Alai,Stephan Niebling,Christian M. Günther,C. Schmidt,Robin Schubert,Huijong Han,J. Boger,Diana C. F. Monteiro,Linlin Zhang,Xinyuanyuan Sun,J. Pletzer-Zelgert,J. Wollenhaupt,Christian G. Feiler,Manfred S. Weiss,Eike C. Schulz,Pedram Mehrabi,Katarina Karničar,Aleksandra Usenik,Jure Loboda,Henning Tidow,Ashwin Chari,Rolf Hilgenfeld,Charlotte Uetrecht,Russell J. Cox,Andrea Zaliani,Tobias Beck,Matthias Rarey,Stephan Günther,Dušan Turk,Winfried Hinrichs,Winfried Hinrichs,Henry N. Chapman,Arwen R. Pearson,Christian Betzel,Alke Meents +103 more
TL;DR: In this article, a high-throughput x-ray crystallographic screen of two repurposing drug libraries against the SARS-CoV-2 main protease (Mpro), which is essential for viral replication, was performed.
Journal ArticleDOI
Origin and temperature dependence of radiation damage in biological samples at cryogenic temperatures
TL;DR: It is shown that hydrogen gas, formed inside the sample during irradiation, rather than intramolecular bond cleavage between non-hydrogen atoms, is mainly responsible for the loss of high-resolution information and contrast in diffraction experiments and microscopy.
Journal ArticleDOI
Status of the crystallography beamlines at PETRA III
Anja Burkhardt,Tim Pakendorf,Bernd Reime,Jan Meyer,Pontus Fischer,Nicolas Stübe,Saravanan Panneerselvam,Olga Lorbeer,Karolina Stachnik,Martin Warmer,Philip Rödig,Dennis Göries,Alke Meents +12 more
TL;DR: In this article, three beamlines for macromolecular crystallography are available to users at the third-generation synchrotron PETRA III in Hamburg: P11, P13 and P14, the latter two operated by EMBL.
Journal ArticleDOI
X-ray focusing with efficient high-NA multilayer Laue lenses
Saša Bajt,Mauro Prasciolu,Holger Fleckenstein,Martin Domaracký,Henry N. Chapman,Andrew J. Morgan,Oleksandr Yefanov,Marc Messerschmidt,Yang Du,Kevin T. Murray,Valerio Mariani,Manuela Kuhn,Steven Aplin,Kanupriya Pande,Pablo Villanueva-Perez,Karolina Stachnik,Joe P. J. Chen,A. Andrejczuk,Alke Meents,Anja Burkhardt,David Pennicard,Xiaojing Huang,Hanfei Yan,Evgeny Nazaretski,Yong S. Chu,Christian Hamm +25 more
TL;DR: A new pair of materials are introduced—tungsten carbide and silicon carbide—to prepare layered structures with smooth and sharp interfaces and with no material phase transitions that hampered the manufacture of previous lenses.