B
Bernhard Ellinger
Researcher at Fraunhofer Society
Publications - 61
Citations - 1907
Bernhard Ellinger is an academic researcher from Fraunhofer Society. The author has contributed to research in topics: Medicine & Trypanosoma brucei. The author has an hindex of 17, co-authored 51 publications receiving 1345 citations. Previous affiliations of Bernhard Ellinger include Max Planck Society.
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Journal ArticleDOI
The Palmitoylation Machinery Is a Spatially Organizing System for Peripheral Membrane Proteins
Oliver Rocks,Marc Gerauer,Nachiket Vartak,Sebastian Koch,Zhi-Ping Huang,Markos Pechlivanis,Jürgen Kuhlmann,Lucas Brunsveld,Anchal Chandra,Bernhard Ellinger,Herbert Waldmann,Philippe I. H. Bastiaens +11 more
TL;DR: This generic spatially organizing system differs from conventional receptor-mediated targeting mechanisms and efficiently counteracts entropy-driven redistribution of palmitoylated peripheral membrane proteins over all membranes.
Journal ArticleDOI
X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease.
Sebastian Günther,P. Reinke,Yaiza Fernández-García,J. Lieske,Thomas J. Lane,Helen M. Ginn,Faisal Hammad Mekky Koua,Christiane Ehrt,W. Ewert,Dominik Oberthuer,Oleksandr Yefanov,S. Meier,Kristina Lorenzen,Boris Krichel,Janine-Denise Kopicki,Luca Gelisio,W. Brehm,Ilona Dunkel,B. Seychell,Henry Gieseler,Brenna Norton-Baker,Brenna Norton-Baker,Beatriz Escudero-Pérez,M. Domaracky,S. Saouane,A. Tolstikova,Thomas A. White,Anna Hänle,M. Groessler,Holger Fleckenstein,F. Trost,M. Galchenkova,Y. Gevorkov,Chufeng Li,Salah Awel,Ariana Peck,Miriam Barthelmess,Frank Schlünzen,P. Lourdu Xavier,N. Werner,H. Andaleeb,N. Ullah,Sven Falke,Vasundara Srinivasan,Bruno Alves Franca,M. Schwinzer,Hévila Brognaro,Cromarte Rogers,D. Melo,Joanna J. Zaitseva-Doyle,Juraj Knoska,Gisel E. Peña-Murillo,Aida Rahmani Mashhour,V. Hennicke,Pontus Fischer,Johanna Hakanpää,Jan Meyer,Philip Gribbon,Bernhard Ellinger,Maria Kuzikov,Markus Wolf,Andrea R. Beccari,Gleb Bourenkov,David von Stetten,Guillaume Pompidor,Isabel Bento,Saravanan Panneerselvam,Ivars Karpics,Thomas R. Schneider,Maria Garcia-Alai,Stephan Niebling,Christian M. Günther,C. Schmidt,Robin Schubert,Huijong Han,J. Boger,Diana C. F. Monteiro,Linlin Zhang,Xinyuanyuan Sun,J. Pletzer-Zelgert,J. Wollenhaupt,Christian G. Feiler,Manfred S. Weiss,Eike C. Schulz,Pedram Mehrabi,Katarina Karničar,Aleksandra Usenik,Jure Loboda,Henning Tidow,Ashwin Chari,Rolf Hilgenfeld,Charlotte Uetrecht,Russell J. Cox,Andrea Zaliani,Tobias Beck,Matthias Rarey,Stephan Günther,Dušan Turk,Winfried Hinrichs,Winfried Hinrichs,Henry N. Chapman,Arwen R. Pearson,Christian Betzel,Alke Meents +103 more
TL;DR: In this article, a high-throughput x-ray crystallographic screen of two repurposing drug libraries against the SARS-CoV-2 main protease (Mpro), which is essential for viral replication, was performed.
Journal ArticleDOI
Multi-endpoint toxicological assessment of polystyrene nano- and microparticles in different biological models in vitro
Michelle Hesler,Leonie Aengenheister,Bernhard Ellinger,Roland Drexel,Susanne Straskraba,Carsten Jost,Sylvia Wagner,Florian Meier,Hagen von Briesen,Claudia Büchel,Peter Wick,Tina Buerki-Thurnherr,Yvonne Kohl +12 more
TL;DR: This study investigated the transport and effects of 50 nm and 0.5 μm COOH-modified polystyrene (PS) particles, as representatives for NP and MP, in different biological models in vitro, and identified them as weak embryotoxic and non-genotoxic.
Journal ArticleDOI
Synthesis and Structure-Activity Correlation of Natural-Product Inspired Cyclodepsipeptides Stabilizing F-Actin
René Tannert,Lech-Gustav Milroy,Bernhard Ellinger,Tai-Shan Hu,Hans-Dieter Arndt,Herbert Waldmann +5 more
TL;DR: An efficient solid-phase approach has been developed and successfully applied to the total synthesis of jasplakinolide and chondramide C and diverse analogues, and a number of potent unnatural and simplified analogues have been found.
Journal ArticleDOI
Biology-oriented synthesis of a natural-product inspired oxepane collection yields a small-molecule activator of the Wnt-pathway.
Sudipta Basu,Bernhard Ellinger,Stefano Rizzo,Céline Deraeve,Markus Schürmann,Hans Preut,Hans-Dieter Arndt,Herbert Waldmann +7 more
TL;DR: A one pot 4–7 step synthesis of mono-, bi-, and tricyclic oxepanes that resemble the core scaffolds of numerous NPs with diverse bioactivities and makes productive use of polymer-immobilized scavenger reagents is developed.