S
Sven Falke
Researcher at University of Hamburg
Publications - 44
Citations - 650
Sven Falke is an academic researcher from University of Hamburg. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 8, co-authored 34 publications receiving 305 citations.
Papers
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Journal ArticleDOI
X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease.
Sebastian Günther,P. Reinke,Yaiza Fernández-García,J. Lieske,Thomas J. Lane,Helen M. Ginn,Faisal Hammad Mekky Koua,Christiane Ehrt,W. Ewert,Dominik Oberthuer,Oleksandr Yefanov,S. Meier,Kristina Lorenzen,Boris Krichel,Janine-Denise Kopicki,Luca Gelisio,W. Brehm,Ilona Dunkel,B. Seychell,Henry Gieseler,Brenna Norton-Baker,Brenna Norton-Baker,Beatriz Escudero-Pérez,M. Domaracky,S. Saouane,A. Tolstikova,Thomas A. White,Anna Hänle,M. Groessler,Holger Fleckenstein,F. Trost,M. Galchenkova,Y. Gevorkov,Chufeng Li,Salah Awel,Ariana Peck,Miriam Barthelmess,Frank Schlünzen,P. Lourdu Xavier,N. Werner,H. Andaleeb,N. Ullah,Sven Falke,Vasundara Srinivasan,Bruno Alves Franca,M. Schwinzer,Hévila Brognaro,Cromarte Rogers,D. Melo,Joanna J. Zaitseva-Doyle,Juraj Knoska,Gisel E. Peña-Murillo,Aida Rahmani Mashhour,V. Hennicke,Pontus Fischer,Johanna Hakanpää,Jan Meyer,Philip Gribbon,Bernhard Ellinger,Maria Kuzikov,Markus Wolf,Andrea R. Beccari,Gleb Bourenkov,David von Stetten,Guillaume Pompidor,Isabel Bento,Saravanan Panneerselvam,Ivars Karpics,Thomas R. Schneider,Maria Garcia-Alai,Stephan Niebling,Christian M. Günther,C. Schmidt,Robin Schubert,Huijong Han,J. Boger,Diana C. F. Monteiro,Linlin Zhang,Xinyuanyuan Sun,J. Pletzer-Zelgert,J. Wollenhaupt,Christian G. Feiler,Manfred S. Weiss,Eike C. Schulz,Pedram Mehrabi,Katarina Karničar,Aleksandra Usenik,Jure Loboda,Henning Tidow,Ashwin Chari,Rolf Hilgenfeld,Charlotte Uetrecht,Russell J. Cox,Andrea Zaliani,Tobias Beck,Matthias Rarey,Stephan Günther,Dušan Turk,Winfried Hinrichs,Winfried Hinrichs,Henry N. Chapman,Arwen R. Pearson,Christian Betzel,Alke Meents +103 more
TL;DR: In this article, a high-throughput x-ray crystallographic screen of two repurposing drug libraries against the SARS-CoV-2 main protease (Mpro), which is essential for viral replication, was performed.
Journal ArticleDOI
Processing of the SARS-CoV pp1a/ab nsp7-10 region.
TL;DR: In this paper, the authors analyzed processing of the coronavirus nsp7-10 region using native mass spectrometry showing consumption of substrate, rise and fall of intermediate products and complexation.
Journal ArticleDOI
Crystal Structure of a Mirror-Image L-RNA Aptamer (Spiegelmer) in Complex with the Natural L-Protein Target CCL2
Dominik Oberthür,John Achenbach,Azat Gabdulkhakov,Klaus Buchner,Christian Maasch,Sven Falke,Dirk Rehders,Sven Klussmann,Christian Betzel +8 more
TL;DR: The crystal structure of a 40mer mirror-image RNA oligonucleotide completely built from nucleotides of the non-natural L-chirality in complex with the pro-inflammatory chemokine L-CLL2 (monocyte chemoattractant protein-1), a natural protein composed of regular L-amino acids is reported.
Book ChapterDOI
Dynamic Light Scattering (DLS)
Sven Falke,Christian Betzel +1 more
TL;DR: In this paper, the photon-correlation spectroscopy (PCS) is used in dynamic light scattering (DLS), which is a widely used analytical method applied in different fields of life and material sciences, as well as in industrial quality control processes.
Journal ArticleDOI
Cm3+/Eu3+ induced structural, mechanistic and functional implications for calmodulin.
Björn Drobot,Moritz Schmidt,Yuji Mochizuki,Yuji Mochizuki,Takaya Abe,Koji Okuwaki,Florian Brulfert,Sven Falke,Sergey A. Samsonov,Yuto Komeiji,Christian Betzel,Thorsten Stumpf,Johannes Raff,Satoru Tsushima,Satoru Tsushima +14 more
TL;DR: A comprehensive picture of the CaM-actinide/lanthanide system from the molecular level to its functional impact is generated, which confirms the higher affinity of Cm3+ and Eu3+ compared to Ca2+ to all 4 binding sites of CaM, with one site differing from the remaining three.