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Aynur Unalp
Researcher at Johns Hopkins University
Publications - 30
Citations - 6001
Aynur Unalp is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Nonalcoholic fatty liver disease & Fatty liver. The author has an hindex of 19, co-authored 30 publications receiving 5142 citations.
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Journal ArticleDOI
Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis
Arun J. Sanyal,Naga Chalasani,Kris V. Kowdley,Arthur J. McCullough,Anna Mae Diehl,Nathan M. Bass,Brent A. Neuschwander-Tetri,Joel E. Lavine,James Tonascia,Aynur Unalp,Mark L. Van Natta,Jeanne M. Clark,Elizabeth M. Brunt,David E. Kleiner,Jay H. Hoofnagle,Patricia R. Robuck +15 more
TL;DR: Vitamin E was superior to placebo for the treatment of nonalcoholic steatohepatitis in adults without diabetes, and significant benefits of pioglitazone were observed for some of the secondary outcomes.
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Effect of Vitamin E or Metformin for Treatment of Nonalcoholic Fatty Liver Disease in Children and Adolescents: The TONIC Randomized Controlled Trial
Joel E. Lavine,Jeffrey B. Schwimmer,Mark L. Van Natta,Jean P. Molleston,Jean P. Molleston,Karen F. Murray,Philip J. Rosenthal,Stephanie H. Abrams,Ann O. Scheimann,Arun J. Sanyal,Naga Chalasani,James Tonascia,Aynur Unalp,Jeanne M. Clark,Elizabeth M. Brunt,David E. Kleiner,Jay H. Hoofnagle,Patricia R. Robuck +17 more
TL;DR: Neither vitamin E nor metformin was superior to placebo in attaining the primary outcome of sustained reduction in ALT level in patients with pediatric NAFLD.
Journal ArticleDOI
Association between diabetes, family history of diabetes, and risk of nonalcoholic steatohepatitis and fibrosis
Rohit Loomba,Maria Roselle Abraham,Aynur Unalp,Laura A. Wilson,Joel E. Lavine,Ed Doo,Nathan M. Bass +6 more
TL;DR: Family history of diabetes, especially among nondiabetics, is associated with NASH and fibrosis in NAFLD, and diabetes is strongly associated with risk of NASH, fibrosis, and advanced fibrosis.
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Portal chronic inflammation in nonalcoholic fatty liver disease (NAFLD): a histologic marker of advanced NAFLD-Clinicopathologic correlations from the nonalcoholic steatohepatitis clinical research network
Elizabeth M. Brunt,David E. Kleiner,Laura Wilson,Aynur Unalp,Cynthia E. Behling,Joel E. Lavine,Brent A. Neuschwander-Tetri,Stephanie H. Abrams,Diana Arceo,Denise Espinosa,Leanel Fairly,Diane Bringman,Carol Hawkins,Yao Chang Liu,Nicholette Rogers,Margaret Stager,Arthur J. McCullough,Srinivasan Dasarathy,Kevin Edwards,Ruth Sargent,Melissa J. Coffey,Karen F. Murray,Melissa Young,Parvathi Mohan,Kavita Nair,Manal F. Abdelmalek,Anna Mae Diehl,Marcia R. Gottfried,Cynthia D. Guy,Paul G. Killenberg,Samantha Kwan,Yi Ping Pan,Dawn Piercy,Melissa Smith,Prajakta Bhimalli,Naga Chalasani,Oscar W. Cummings,Lydia Lee,Linda Ragozzino,Raj Vuppalanchi,Barbara Calabrese,Debra Peglow,Ann O. Scheimann,Michael Torbenson,Ann Klipsch,Jean P. Molleston,Girish Subbarao,Sarah E. Barlow,Jose Derdoy,Joyce Hoffmann,Debra King,Joan Siegner,Susan Stewart,Brent A. Tetri,Judy Thompson,Cynthia Behling,Manual Celedon,Lisa Clark,Janis Durelle,Tarek Hassanein,Susana Mendoza,Jeffrey B. Schwimmer,Claude B. Sirlin,Tanya Stein,Allison Tobin,Kiran Bambha,Nathan M. Bass,Linda D. Ferrell,Danuta Filipowski,Raphael B. Merriman,Mark Pabst,Monique Rosenthal,Philip J. Rosenthal,Tessa Steel,Sherry Boyett,Daphne Bryan,Melissa J. Contos,Michael Fuchs,Martin F. Graham,Amy Jones,Velimir A. Luketic,Bimalijit Sandhu,Arun J. Sanyal,Carol Sargeant,Kimberly Selph,Melanie B. White,Kris V. Kowdley,Grace Gyurkey,Jody Mooney,James E. Nelson,Sarah Roberts,Cheryl Saunders,Alice Stead,Chia Wang,Matthew M. Yeh,Elizabeth M. Brunt,D Kleiner,Gilman D. Grave,Terry T.-K. Huang,Edward Doo,Jay E. Everhart,Jay H. Hoofnagle,Patricia R. Robuck,Leonard B. Seeff,Patricia Belt,Fred Brancati,Jeanne M. Clark,Ryan Colvin,Michel Donithan,Mika Green,Rosemary Hollick,Milana Isaacson,Wana Kim,Alison Lyndecker,Laura Miriel,Alice L. Sternberg,James Tonascia,Aynur Unalp-Arida,Mark L. Van Natta,Laura A. Wilson,Katherine P. Yates +120 more
TL;DR: Increased portal CI is associated with many clinical and pathologic features of progressive NAFLD in both adults and children, but not with ALT, autoantibodies, or lobular inflammation.
Journal ArticleDOI
Relationship of steatosis grade and zonal location to histological features of steatohepatitis in adult patients with non-alcoholic fatty liver disease
Naga Chalasani,Laura A. Wilson,David E. Kleiner,Oscar W. Cummings,Elizabeth M. Brunt,Aynur Unalp +5 more
TL;DR: Patients with severe steatosis are more likely to have steatohepatitis, and pan-acinar ste atosis was more often associated with ballooning, Mallory bodies, and advanced fibrosis.