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Barbara L. Weber
Researcher at University of Pennsylvania
Publications - 9
Citations - 1420
Barbara L. Weber is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Breast cancer & Odds ratio. The author has an hindex of 8, co-authored 9 publications receiving 1373 citations. Previous affiliations of Barbara L. Weber include Aarhus University Hospital.
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Journal ArticleDOI
Oral contraceptives and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers
Steven A. Narod,Marie-Pierre Dubé,Jan Klijn,Jan Lubinski,Henry T. Lynch,Parviz Ghadirian,Daine Provencher,Ketil Heimdal,Pål Møller,Mark E. Robson,Kenneth Offit,Claudine Isaacs,Barbara L. Weber,Eitan Friedman,Ruth Gershoni-Baruch,Gad Rennert,Barbara Pasini,Theresa Wagner,Mary B. Daly,Judy Garber,Susan L. Neuhausen,Peter Ainsworth,Håkan Olsson,Gareth Evans,Michael P. Osborne,Fergus J. Couch,William D. Foulkes,Ellen Warner,Charmaine Kim-Sing,Olufunmilayo I. Olopade,Nadine Tung,Howard M. Saal,Jeffrey N. Weitzel,Sofia D. Merajver,Marion Gauthier-Villars,Helena Jernström,Ping Sun,Jean Sébastien Brunet +37 more
TL;DR: Among BRCA1 mutation carriers, women who first used oral contraceptives before 1975, who used them before age 30, or who use them for 5 or more years may have an increased risk of early-onset breast cancer.
Journal ArticleDOI
Pregnancy and risk of early breast cancer in carriers of BRCA1 and BRCA2
Helena Jernström,Caryn Lerman,Parviz Ghadirian,Henry T. Lynch,Barbara L. Weber,Judy Garber,M. Daly,Olufunmilayo I. Olopade,William D. Foulkes,Ellen Warner,Jean-Sébastien Brunet,Steven A. Narod +11 more
TL;DR: Whether pregnancy is a risk factor for hereditary breast cancer is established and an early first pregnancy does not confer protection for carriers of BRCA1 or BRCa2 mutations.
Journal ArticleDOI
ASCO/SSO Review of Current Role of Risk-Reducing Surgery in Common Hereditary Cancer Syndromes
Jose G. Guillem,William C. Wood,Jeffrey F. Moley,Andrew Berchuck,Beth Y. Karlan,David G. Mutch,Robert F. Gagel,Jeffrey N. Weitzel,Monica Morrow,Barbara L. Weber,Francis M. Giardiello,Miguel A. Rodriguez-Bigas,James Church,Stephen B. Gruber,Kenneth Offit +14 more
TL;DR: The issues surrounding the why, how, and when of surgical prophylaxis for inherited forms of cancer are focused on.
Journal ArticleDOI
Effect of pregnancy as a risk factor for breast cancer in BRCA1/BRCA2 mutation carriers.
Carey A. Cullinane,Jan Lubinski,Susan L. Neuhausen,Parviz Ghadirian,Henry T. Lynch,Claudine Isaacs,Barbara L. Weber,Pål Møller,Kenneth Offit,Charmaine Kim-Sing,Eitan Friedman,Susan Randall,Barbara Pasini,Peter Ainsworth,Ruth Gershoni-Baruch,William D. Foulkes,Jan Klijn,Nadine Tung,Gad Rennert,Olufunmilayo I. Olopade,Fergus J. Couch,T Wagner,Håkan Olsson,Ping Sun,Jeffrey N. Weitzel,Steven A. Narod +25 more
TL;DR: Among BRCA2 carriers, increasing parity was associated with a significant increase in the risk of breast cancer before age 50 and this increase was greatest in the 2‐year period following a pregnancy.
Journal ArticleDOI
ASCO/SSO review of current role of risk-reducing surgery in common hereditary cancer syndromes.
Jose G. Guillem,William C. Wood,Jeffrey F. Moley,Andrew Berchuck,Beth Y. Karlan,David G. Mutch,Robert F. Gagel,Jeffrey N. Weitzel,Monica Morrow,Barbara L. Weber,Francis M. Giardiello,Miguel A. Rodriguez-Bigas,James Church,Stephen B. Gruber,Kenneth Offit +14 more
TL;DR: Risk-reducing surgical treatment of hereditary cancer is a complex undertaking that requires a clear understanding of the natural history of the disease, realistic appreciation of the potential benefits and risks of these procedures in potentially otherwise healthy individuals, and the long-term sequelae of such interventions.