A
Asta Försti
Researcher at German Cancer Research Center
Publications - 303
Citations - 8714
Asta Försti is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Cancer & Population. The author has an hindex of 40, co-authored 263 publications receiving 6760 citations. Previous affiliations of Asta Försti include Guy's and St Thomas' NHS Foundation Trust & Lund University.
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Journal ArticleDOI
Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes
Nasim Mavaddat,Kyriaki Michailidou,Kyriaki Michailidou,Joe Dennis,Michael Lush,Laura Fachal,Andrew Lee,Jonathan Tyrer,Ting Huei Chen,Qin Wang,Manjeet K. Bolla,Xin Yang,Muriel A. Adank,Thomas U. Ahearn,Kristiina Aittomäki,Jamie Allen,Irene L. Andrulis,Irene L. Andrulis,Hoda Anton-Culver,Natalia Antonenkova,Volker Arndt,Kristan J. Aronson,Paul L. Auer,Paul L. Auer,Päivi Auvinen,Myrto Barrdahl,Laura E. Beane Freeman,Matthias W. Beckmann,Sabine Behrens,Javier Benitez,Marina Bermisheva,Leslie Bernstein,Carl Blomqvist,Carl Blomqvist,Natalia Bogdanova,Stig E. Bojesen,Stig E. Bojesen,Bernardo Bonanni,Anne Lise Børresen-Dale,Anne Lise Børresen-Dale,Hiltrud Brauch,Hiltrud Brauch,Hiltrud Brauch,Michael Bremer,Hermann Brenner,Adam R. Brentnall,Ian W. Brock,Angela Brooks-Wilson,Angela Brooks-Wilson,Sara Y. Brucker,Thomas Brüning,Barbara Burwinkel,Barbara Burwinkel,Daniele Campa,Daniele Campa,Brian D. Carter,Jose E. Castelao,Stephen J. Chanock,Rowan T. Chlebowski,Hans Christiansen,Christine L. Clarke,J. Margriet Collée,Emilie Cordina-Duverger,Sten Cornelissen,Fergus J. Couch,Angela Cox,Simon S. Cross,Kamila Czene,Mary B. Daly,Peter Devilee,Thilo Dörk,Isabel dos-Santos-Silva,Martine Dumont,Lorraine Durcan,Miriam Dwek,Diana Eccles,Arif B. Ekici,A. Heather Eliassen,A. Heather Eliassen,Carolina Ellberg,Christoph Engel,Mikael Eriksson,D. Gareth Evans,Peter A. Fasching,Peter A. Fasching,Jonine D. Figueroa,Jonine D. Figueroa,Olivia Fletcher,Henrik Flyger,Asta Försti,Asta Försti,Lin Fritschi,Marike Gabrielson,Manuela Gago-Dominguez,Susan M. Gapstur,José A. García-Sáenz,Mia M. Gaudet,Vassilios Georgoulias,Graham G. Giles,Graham G. Giles,Graham G. Giles,I. R. Gilyazova,I. R. Gilyazova,Gord Glendon,Mark S. Goldberg,David E. Goldgar,Anna González-Neira,Grethe I. Grenaker Alnæs,Mervi Grip,Jacek Gronwald,Anne Grundy,Pascal Guénel,Lothar Haeberle,Eric Hahnen,Christopher A. Haiman,Niclas Håkansson,Ute Hamann,Susan E. Hankinson,Elaine F. Harkness,Elaine F. Harkness,Steven N. Hart,Wei He,Alexander Hein,Jane Heyworth,Peter Hillemanns,Antoinette Hollestelle,Maartje J. Hooning,Robert N. Hoover,John L. Hopper,Anthony Howell,Guanmengqian Huang,Keith Humphreys,David J. Hunter,David J. Hunter,Milena Jakimovska,Anna Jakubowska,Anna Jakubowska,Wolfgang Janni,Esther M. John,Nichola Johnson,Michael Jones,Arja Jukkola-Vuorinen,Audrey Y. Jung,Rudolf Kaaks,Katarzyna Kaczmarek,Vesa Kataja,Renske Keeman,Michael J. Kerin,Elza Khusnutdinova,Elza Khusnutdinova,Johanna I. Kiiski,Julia A. Knight,Julia A. Knight,Yon-Dschun Ko,Veli-Matti Kosma,Stella Koutros,Vessela N. Kristensen,Vessela N. Kristensen,Ute Krüger,Tabea Kühl,Diether Lambrechts,Loic Le Marchand,Eunjung Lee,Flavio Lejbkowicz,Jenna Lilyquist,Annika Lindblom,Sara Lindström,Sara Lindström,Jolanta Lissowska,Wing-Yee Lo,Wing-Yee Lo,Sibylle Loibl,Jirong Long,Jan Lubinski,Michael P. Lux,Robert J. MacInnis,Robert J. MacInnis,Tom Maishman,Enes Makalic,Ivana Maleva Kostovska,Arto Mannermaa,Siranoush Manoukian,Sara Margolin,John W.M. Martens,Maria Elena Martinez,Dimitrios Mavroudis,Catriona McLean,Alfons Meindl,Usha Menon,Pooja Middha,Pooja Middha,Nicola Miller,Fernando Salvador Moreno,Anna Marie Mulligan,Anna Marie Mulligan,Claire Mulot,Victor Muñoz-Garzón,Susan L. Neuhausen,Heli Nevanlinna,Patrick Neven,William G. Newman,Sune F. Nielsen,Børge G. Nordestgaard,Børge G. Nordestgaard,Aaron D. Norman,Kenneth Offit,Janet E. Olson,Håkan Olsson,Nick Orr,V. Shane Pankratz,Tjoung-Won Park-Simon,Jose Ignacio Arias Perez,Clara Pérez-Barrios,Paolo Peterlongo,Julian Peto,Mila Pinchev,Dijana Plaseska-Karanfilska,Eric C. Polley,Ross L. Prentice,Nadege Presneau,Darya Prokofyeva,Kristen S. Purrington,Katri Pylkäs,Brigitte Rack,Paolo Radice,Rohini Rau-Murthy,Gad Rennert,Hedy S. Rennert,Valerie Rhenius,Mark E. Robson,Atocha Romero,Kathryn J. Ruddy,Matthias Ruebner,Emmanouil Saloustros,Dale P. Sandler,Elinor J. Sawyer,Daniel F. Schmidt,Daniel F. Schmidt,Rita K. Schmutzler,Andreas Schneeweiss,Minouk J. Schoemaker,Fredrick R. Schumacher,Peter Schürmann,Lukas Schwentner,Christopher G. Scott,Rodney J. Scott,Rodney J. Scott,Caroline Seynaeve,Mitul Shah,Mark E. Sherman,Martha J. Shrubsole,Xiao-Ou Shu,Susan L. Slager,Ann Smeets,Christof Sohn,Penny Soucy,Melissa C. Southey,Melissa C. Southey,John J. Spinelli,Christa Stegmaier,Jennifer Stone,Jennifer Stone,Anthony J. Swerdlow,Rulla M. Tamimi,Rulla M. Tamimi,William J. Tapper,Jack A. Taylor,Mary Beth Terry,Kathrin Thöne,Rob A. E. M. Tollenaar,Ian Tomlinson,Ian Tomlinson,Thérèse Truong,Maria Tzardi,Hans-Ulrich Ulmer,Michael Untch,Celine M. Vachon,Elke M van Veen,Joseph Vijai,Clarice R. Weinberg,Camilla Wendt,Alice S. Whittemore,Hans Wildiers,Walter C. Willett,Walter C. Willett,Robert Winqvist,Alicja Wolk,Alicja Wolk,Xiaohong R. Yang,Drakoulis Yannoukakos,Yan Zhang,Wei Zheng,Argyrios Ziogas,Alison M. Dunning,Deborah J. Thompson,Georgia Chenevix-Trench,Jenny Chang-Claude,Jenny Chang-Claude,Marjanka K. Schmidt,Per Hall,Roger L. Milne,Roger L. Milne,Roger L. Milne,Paul D.P. Pharoah,Antonis C. Antoniou,Nilanjan Chatterjee,Nilanjan Chatterjee,Peter Kraft,Montserrat Garcia-Closas,Jacques Simard,Douglas F. Easton +310 more
TL;DR: This PRS, optimized for prediction of estrogen receptor (ER)-specific disease, from the largest available genome-wide association dataset is developed and empirically validated and is a powerful and reliable predictor of breast cancer risk that may improve breast cancer prevention programs.
Journal ArticleDOI
Prediction of Breast Cancer Risk Based on Profiling With Common Genetic Variants
Nasim Mavaddat,Paul D.P. Pharoah,Kyriaki Michailidou,Jonathan Tyrer,Mark N. Brook,Mark N. Brook,Manjeet K. Bolla,Qin Wang,Joe Dennis,Alison M. Dunning,Mitul Shah,Robert Luben,Judith E. Brown,Stig E. Bojesen,Børge G. Nordestgaard,Sune F. Nielsen,Henrik Flyger,Kamila Czene,Hatef Darabi,Mikael Eriksson,Julian Peto,Isabel dos-Santos-Silva,Frank Dudbridge,Nichola Johnson,Marjanka K. Schmidt,Annegien Broeks,Senno Verhoef,Emiel J. Th. Rutgers,Anthony J. Swerdlow,Alan Ashworth,Nick Orr,Minouk J. Schoemaker,Jonine D. Figueroa,Stephen J. Chanock,Louise A. Brinton,Jolanta Lissowska,Fergus J. Couch,Janet E. Olson,Celine M. Vachon,Vernon S. Pankratz,Diether Lambrechts,Diether Lambrechts,Hans Wildiers,Chantal Van Ongeval,Erik Van Limbergen,Vessela N. Kristensen,Vessela N. Kristensen,Grethe I. Grenaker Alnæs,Silje Nord,Anne Lise Børresen-Dale,Anne Lise Børresen-Dale,Heli Nevanlinna,Taru A. Muranen,Kristiina Aittomäki,Carl Blomqvist,Jenny Chang-Claude,Anja Rudolph,Petra Seibold,Dieter Flesch-Janys,Peter A. Fasching,Peter A. Fasching,Lothar Haeberle,Arif B. Ekici,Matthias W. Beckmann,Barbara Burwinkel,Barbara Burwinkel,Frederik Marme,Frederik Marme,Andreas Schneeweiss,Andreas Schneeweiss,Christof Sohn,Amy Trentham-Dietz,Polly A. Newcomb,Polly A. Newcomb,Linda Titus,Kathleen M. Egan,David J. Hunter,David J. Hunter,Sara Lindström,Sara Lindström,Rulla M. Tamimi,Peter Kraft,Peter Kraft,Nazneen Rahman,Clare Turnbull,Anthony Renwick,Sheila Seal,Sheila Seal,Jingmei Li,Jianjun Liu,Keith Humphreys,Javier Benitez,Javier Benitez,M. Pilar Zamora,Jose Ignacio Arias Perez,Primitiva Menéndez,Anna Jakubowska,Jan Lubinski,Katarzyna Jaworska-Bieniek,Katarzyna Durda,Natalia Bogdanova,Natalia Bogdanova,Natalia Antonenkova,Thilo Dörk,Hoda Anton-Culver,Susan L. Neuhausen,Argyrios Ziogas,Leslie Bernstein,Peter Devilee,Robert A.E.M. Tollenaar,Caroline M. Seynaeve,Christi J. van Asperen,Angela Cox,Simon S. Cross,Malcolm W.R. Reed,Elza Khusnutdinova,Marina Bermisheva,Marina Bermisheva,Darya Prokofyeva,Zalina Takhirova,Alfons Meindl,Rita K. Schmutzler,Rita K. Schmutzler,Christian Sutter,Rongxi Yang,Rongxi Yang,Peter Schürmann,Michael Bremer,Hans Christiansen,Tjoung Won Park-Simon,Peter Hillemanns,Pascal Guénel,Pascal Guénel,Thérèse Truong,Thérèse Truong,Florence Menegaux,Florence Menegaux,Marie Sanchez,Marie Sanchez,Paolo Radice,Paolo Peterlongo,Siranoush Manoukian,Valeria Pensotti,John L. Hopper,Helen Tsimiklis,Carmel Apicella,Melissa C. Southey,Hiltrud Brauch,Hiltrud Brauch,Hiltrud Brauch,Thomas Brüning,Yon Ko,Yon Ko,Alice J. Sigurdson,Michele M. Doody,Ute Hamann,Diana Torres,Hans Ulrich Ulmer,Asta Försti,Elinor J. Sawyer,Ian Tomlinson,Michael J. Kerin,Nicola Miller,Irene L. Andrulis,Irene L. Andrulis,Julia A. Knight,Gord Glendon,Anna Marie Mulligan,Anna Marie Mulligan,Georgia Chenevix-Trench,Rosemary L. Balleine,Graham G. Giles,Roger L. Milne,Catriona McLean,Annika Lindblom,Sara Margolin,Christopher A. Haiman,Brian E. Henderson,Fredrick R. Schumacher,Loic Le Marchand,Ursula Eilber,Shan Wang-Gohrke,Maartje J. Hooning,Antoinette Hollestelle,Ans M.W. van den Ouweland,Linetta B. Koppert,Jane Carpenter,Christine L. Clarke,Rodney J. Scott,Arto Mannermaa,Vesa Kataja,Veli-Matti Kosma,Jaana M. Hartikainen,Hermann Brenner,Volker Arndt,Christa Stegmaier,Aida Karina Dieffenbach,Robert Winqvist,Katri Pylkäs,Arja Jukkola-Vuorinen,Mervi Grip,Kenneth Offit,Kenneth Offit,Joseph Vijai,Joseph Vijai,Mark E. Robson,Rohini Rau-Murthy,Miriam Dwek,Miriam Dwek,Ruth Swann,Katherine Annie Perkins,Mark S. Goldberg,Mark S. Goldberg,Martine Dumont,Diana Eccles,William J. Tapper,Sajjad Rafiq,Esther M. John,Esther M. John,Alice S. Whittemore,Susan L. Slager,Drakoulis Yannoukakos,Amanda E. Toland,Song Yao,Wei Zheng,Sandra L. Halverson,Anna González-Neira,G Pita,M. Rosario Alonso,Nuria Álvarez,Daniel Herrero,Daniel C. Tessier,Daniel Vincent,Francois Bacot,Craig Luccarini,Caroline Baynes,Shahana Ahmed,Mel Maranian,Catherine S. Healey,Jacques Simard,Per Hall,Douglas F. Easton,Montserrat Garcia-Closas +242 more
TL;DR: The PRS stratifies breast cancer risk in women both with and without a family history of breast cancer, and the observed level of risk discrimination could inform targeted screening and prevention strategies.
Journal ArticleDOI
Breast Cancer Risk Genes - Association Analysis in More than 113,000 Women
Leila Dorling,Sara Carvalho,Jamie Allen,Anna González-Neira,Craig Luccarini,Cecilia Wahlström,Karen A. Pooley,Michael T. Parsons,Cristina Fortuno,Qin Wang,Manjeet K. Bolla,Joe Dennis,Renske Keeman,M. Rosario Alonso,Nuria Álvarez,Belen Herraez,Victoria Fernández,Rocio Núñez-Torres,Ana Osorio,Jeanette Valcich,Minerva Li,Therese Törngren,Patricia Harrington,Caroline Baynes,Don M. Conroy,Brennan Decker,Laura Fachal,Nasim Mavaddat,Thomas U. Ahearn,Kristiina Aittomäki,Natalia Antonenkova,Norbert Arnold,Patrick Arveux,Margreet G. E. M. Ausems,Päivi Auvinen,Heiko Becher,Matthias W. Beckmann,Sabine Behrens,Marina Bermisheva,Katarzyna Białkowska,Carl Blomqvist,Natalia Bogdanova,Nadja Bogdanova-Markov,Stig E. Bojesen,Bernardo Bonanni,Anne Lise Børresen-Dale,Hiltrud Brauch,Michael Bremer,Ignacio Briceño,Thomas Brüning,Barbara Burwinkel,David Cameron,Nicola J. Camp,Archie Campbell,Angel Carracedo,Jose E. Castelao,Melissa H. Cessna,Stephen J. Chanock,Hans Christiansen,J. Margriet Collée,Emilie Cordina-Duverger,Sten Cornelissen,Kamila Czene,Thilo Dörk,Arif B. Ekici,Christoph Engel,Mikael Eriksson,Peter A. Fasching,Jonine D. Figueroa,Henrik Flyger,Asta Försti,Marike Gabrielson,Manuela Gago-Dominguez,Vassilios Georgoulias,Fabián Gil,Graham G. Giles,Gord Glendon,Encarna B. Gomez Garcia,Grethe I. Grenaker Alnæs,Pascal Guénel,Andreas Hadjisavvas,Lothar Haeberle,Eric Hahnen,Per Hall,Ute Hamann,Elaine F. Harkness,Jaana M. Hartikainen,Mikael Hartman,Wei He,Bernadette A M Heemskerk-Gerritsen,Peter Hillemanns,Frans B. L. Hogervorst,Antoinette Hollestelle,Weang Kee Ho,Maartje J. Hooning,Anthony Howell,Keith Humphreys,Faiza Idris,Anna Jakubowska,Audrey Y. Jung,Pooja Middha Kapoor,Michael J. Kerin,Elza Khusnutdinova,Sung-Won Kim,Yon-Dschun Ko,Veli-Matti Kosma,Vessela N. Kristensen,Kyriacos Kyriacou,Inge M. M. Lakeman,Jong Won Lee,Min Hyuk Lee,Jingmei Li,Annika Lindblom,Wing-Yee Lo,Maria A. Loizidou,Artitaya Lophatananon,Jan Lubinski,Robert J. MacInnis,Michael J. Madsen,Arto Mannermaa,Mehdi Manoochehri,Siranoush Manoukian,Sara Margolin,Maria Elena Martinez,Tabea Maurer,Dimitrios Mavroudis,Catriona McLean,Alfons Meindl,Arjen R. Mensenkamp,Kyriaki Michailidou,Nicola Miller,Nur Aishah Taib,Kenneth Muir,Anna Marie Mulligan,Heli Nevanlinna,William G. Newman,Børge G. Nordestgaard,Pei-Sze Ng,Jan C. Oosterwijk,Sue K. Park,Tjoung-Won Park-Simon,Jose Ignacio Arias Perez,Paolo Peterlongo,David J. Porteous,Karolina Prajzendanc,Darya Prokofyeva,Paolo Radice,Muhammad Usman Rashid,Valerie Rhenius,Matti A. Rookus,Thomas Rüdiger,Emmanouil Saloustros,Elinor J. Sawyer,Rita K. Schmutzler,Andreas Schneeweiss,Peter Schürmann,Mitul Shah,Christof Sohn,Melissa C. Southey,Harald Surowy,Maija Suvanto,Somchai Thanasitthichai,Ian Tomlinson,Diana Torres,Thérèse Truong,Maria Tzardi,Yana Valova,Christi J. van Asperen,Rob M. van Dam,Ans M.W. van den Ouweland,Lizet E. van der Kolk,Elke M van Veen,Camilla Wendt,Justin A. Williams,Xiaohong R. Yang,Sook-Yee Yoon,M. Pilar Zamora,D. Gareth Evans,Miguel de la Hoya,Jacques Simard,Antonis C. Antoniou,Åke Borg,Irene L. Andrulis,Jenny Chang-Claude,Montserrat Garcia-Closas,Georgia Chenevix-Trench,Roger L. Milne,Paul D.P. Pharoah,Marjanka K. Schmidt,Amanda B. Spurdle,Maaike P.G. Vreeswijk,Javier Benitez,Alison M. Dunning,Anders Kvist,Soo Hwang Teo,Peter Devilee,Douglas F. Easton +196 more
TL;DR: The results of this study define the genes that are most clinically useful for inclusion on panels for the prediction of breast cancer risk, as well as provide estimates of the risks associated with protein-truncating variants, to guide genetic counseling.
Journal ArticleDOI
Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases A Mendelian Randomization Study
Philip C Haycock,Stephen Burgess,Aayah Nounu,Jie Zheng,G N Okoli,Jack Bowden,Kaitlin H Wade,Nicholas J. Timpson,David M. Evans,Peter Willeit,Abraham Aviv,Tom R. Gaunt,Gibran Hemani,Massimo Mangino,Hayley P Ellis,Kathreena M Kurian,Karen A. Pooley,Rosalind A. Eeles,Jeffrey E. Lee,Shenying Fang,Wei V. Chen,Matthew Law,Lisa Bowdler,Mark M. Iles,Qiong Yang,Bradford B. Worrall,Hugh S. Markus,Rayjean J. Hung,Christopher I. Amos,Amanda B. Spurdle,Deborah J. Thompson,Tracy A. O'Mara,Brian M. Wolpin,Laufey T. Amundadottir,Rachael Z. Stolzenberg-Solomon,Antonia Trichopoulou,N. Charlotte Onland-Moret,Eiliv Lund,Eric J. Duell,Federico Canzian,Gianluca Severi,Kim Overvad,Marc J. Gunter,Rosario Tumino,Ulrika Svenson,Andre M. van Rij,Annette F. Baas,Matthew J. Bown,Nilesh J. Samani,Femke N G van t'Hof,Gerard Tromp,Gregory T. Jones,Helena Kuivaniemi,James R. Elmore,Mattias Johansson,James McKay,Ghislaine Scelo,Robert Carreras-Torres,Valerie Gaborieau,Paul Brennan,Paige M. Bracci,Rachel E. Neale,Sara H. Olson,Steven Gallinger,Donghui Li,Gloria M. Petersen,Harvey A. Risch,Alison P. Klein,Jiali Han,Christian C. Abnet,Neal D. Freedman,Philip R. Taylor,John M. Maris,Katja K.H. Aben,Lambertus A. Kiemeney,Sita H. Vermeulen,John K. Wiencke,Kyle M. Walsh,Margaret Wrensch,Terri Rice,Clare Turnbull,Kevin Litchfield,Lavinia Paternoster,Marie Standl,Gonçalo R. Abecasis,John Paul SanGiovanni,Yong Li,Vladan Mijatovic,Yadav Sapkota,Siew-Kee Low,Krina T. Zondervan,Grant W. Montgomery,Dale R. Nyholt,David A. van Heel,Karen A. Hunt,Dan E. Arking,Foram N. Ashar,Nona Sotoodehnia,Daniel Woo,Jonathan Rosand,Mary E. Comeau,W. Mark Brown,Edwin K. Silverman,John E. Hokanson,Michael H. Cho,Jennie Hui,Manuel A. R. Ferreira,Philip J. Thompson,Alanna C. Morrison,Janine F. Felix,Nicholas L. Smith,Angela M. Christiano,Lynn Petukhova,Regina C. Betz,Xing Fan,Xuejun Zhang,Caihong Zhu,Carl D. Langefeld,Susan D. Thompson,Feijie Wang,Xu Lin,David A. Schwartz,Tasha E. Fingerlin,Jerome I. Rotter,Mary Frances Cotch,Richard A. Jensen,Matthias Munz,Henrik Dommisch,Arne S. Schaefer,Fang Han,Hanna Ollila,Ryan P. Hillary,Omar M. E. Albagha,Stuart H. Ralston,Chenjie Zeng,Wei Zheng,Xiao-Ou Shu,André Reis,Steffen Uebe,Ulrike Hüffmeier,Yoshiya Kawamura,Takeshi Otowa,Tsukasa Sasaki,Martin L. Hibberd,Sonia Davila,Gang Xie,Katherine A. Siminovitch,Jin-Xin Bei,Yi Xin Zeng,Asta Försti,Bowang Chen,Stefano Landi,Andre Franke,Annegret Fischer,David Ellinghaus,Carlos Flores,Imre Noth,Shwu-Fan Ma,Jia Nee Foo,Jianjun Liu,Jong-Won Kim,David G. Cox,Olivier Delattre,Olivier Mirabeau,Christine F. Skibola,Clara S. Tang,Merce Garcia-Barcelo,Kai-Ping Chang,Wen-Hui Su,Yu-Sun Chang,Nicholas G. Martin,Scott D. Gordon,Tracey D. Wade,Chaeyoung Lee,Michiaki Kubo,Pei-Chieng Cha,Yusuke Nakamura,Daniel Levy,Masayuki Kimura,Shih-Jen Hwang,Steven C. Hunt,Tim D. Spector,Nicole Soranzo,Ani Manichaikul,R. Graham Barr,Bratati Kahali,Elizabeth K. Speliotes,Laura M. Yerges-Armstrong,Ching-Yu Cheng,Jost B. Jonas,Tien Yin Wong,Isabella Fogh,Kuang Lin,John Powell,Kenneth Rice,Caroline L Relton,Richard M. Martin,George Davey Smith +197 more
TL;DR: It is likely that longer telomeres increase risk for several cancers but reduce risk for some non-neoplastic diseases, including cardiovascular diseases, as well as single nucleotide polymorphisms (SNPs) that are strongly associated with telomere length in the general population.
Journal ArticleDOI
A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer
Christopher A. Haiman,Gary K. Chen,Celine M. Vachon,Federico Canzian,Alison M. Dunning,Robert C. Millikan,Xianshu Wang,Foluso O. Ademuyiwa,Shahana Ahmed,Christine B. Ambrosone,Laura Baglietto,Rosemary L. Balleine,Elisa V. Bandera,Matthias W. Beckmann,Christine D. Berg,Leslie Bernstein,Carl Blomqvist,William J. Blot,Hiltrud Brauch,Hiltrud Brauch,Julie E. Buring,Lisa A. Carey,Jane Carpenter,Jenny Chang-Claude,Stephen J. Chanock,Daniel I. Chasman,Christine L. Clarke,Angela Cox,Simon S. Cross,Sandra L. Deming,Robert B. Diasio,Athanasios M. Dimopoulos,W. Ryan Driver,Thomas Dünnebier,Lorraine Durcan,Diana Eccles,Christopher K. Edlund,Arif B. Ekici,Peter A. Fasching,Peter A. Fasching,Heather Spencer Feigelson,Dieter Flesch-Janys,Florentia Fostira,Asta Försti,Asta Försti,George Fountzilas,S Gerty,Graham G. Giles,Andrew K. Godwin,Paul J. Goodfellow,Nikki Graham,Dario Greco,Ute Hamann,Susan E. Hankinson,Arndt Hartmann,Rebecca Hein,Judith Heinz,Andrea Holbrook,Robert N. Hoover,Jennifer J. Hu,David J. Hunter,Sue A. Ingles,Astrid Irwanto,Jennifer Ivanovich,Esther M. John,Esther M. John,Nicola F. Johnson,Arja Jukkola-Vuorinen,Rudolf Kaaks,Yon Ko,Laurence N. Kolonel,Irene Konstantopoulou,Veli-Matti Kosma,Swati Kulkarni,Diether Lambrechts,Diether Lambrechts,Adam M. Lee,Loic Le Marchand,Timothy G. Lesnick,Jianjun Liu,Sara Lindström,Arto Mannermaa,Sara Margolin,Nicholas G. Martin,Penelope Miron,Grant W. Montgomery,Heli Nevanlinna,Stephan Nickels,Sarah J. Nyante,Curtis Olswold,Julie R. Palmer,Harsh B. Pathak,Dimitrios Pectasides,Charles M. Perou,Julian Peto,Paul D.P. Pharoah,Loreall Pooler,Michael F. Press,Katri Pylkäs,Timothy R. Rebbeck,Jorge L. Rodriguez-Gil,Lynn Rosenberg,Eric A. Ross,Thomas Rüdiger,Isabel dos Santos Silva,Elinor J. Sawyer,Marjanka K. Schmidt,Rüdiger Schulz-Wendtland,Fredrick R. Schumacher,Gianluca Severi,Xin Sheng,Lisa B. Signorello,Hans-Peter Sinn,Kristen N. Stevens,Melissa C. Southey,William J. Tapper,Ian Tomlinson,Frans B. L. Hogervorst,Els Wauters,Els Wauters,JoEllen Weaver,Hans Wildiers,Robert Winqvist,David Van Den Berg,Peggy Wan,Lucy Xia,Drakoulis Yannoukakos,Wei Zheng,Regina G. Ziegler,Afshan Siddiq,Susan L. Slager,Daniel O. Stram,Douglas F. Easton,Peter Kraft,Brian E. Henderson,Fergus J. Couch +135 more
TL;DR: The results identify a genetic locus associated with estrogen receptor negative breast cancer subtypes in multiple populations in multiple population of women.