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Claudia S. Huettner
Researcher at Harvard University
Publications - 31
Citations - 3656
Claudia S. Huettner is an academic researcher from Harvard University. The author has contributed to research in topics: Progenitor cell & Haematopoiesis. The author has an hindex of 19, co-authored 31 publications receiving 3466 citations. Previous affiliations of Claudia S. Huettner include Gulf Coast Regional Blood Center & University of Toronto.
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Journal ArticleDOI
miR-328 Functions as an RNA Decoy to Modulate hnRNP E2 Regulation of mRNA Translation in Leukemic Blasts
Anna M. Eiring,Jason G. Harb,Paolo Neviani,Christopher Garton,Joshua J. Oaks,Riccardo Spizzo,Shujun Liu,Sebastian Schwind,Ramasamy Santhanam,Christopher Hickey,Heiko Becker,Jason C. Chandler,Raul Andino,Jorge E. Cortes,Peter Hokland,Claudia S. Huettner,Ravi Bhatia,Denis C. Roy,Stephen A. Liebhaber,Michael A. Caligiuri,Guido Marcucci,Ramiro Garzon,Carlo M. Croce,George A. Calin,Danilo Perrotti +24 more
TL;DR: It is reported that loss of miR-328 occurs in blast crisis chronic myelogenous leukemia in a BCR/ABL dose- and kinase-dependent manner through the MAPK-hnRNP E2 pathway.
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Enhancement of Hematopoietic Stem Cell Repopulating Capacity and Self-Renewal in the Absence of the Transcription Factor C/EBPα
Pu Zhang,Junko Iwasaki-Arai,Hiromi Iwasaki,Maris Fenyus,Tajhal Dayaram,Bronwyn M. Owens,Hirokazu Shigematsu,Elena Levantini,Claudia S. Huettner,Julie A. Lekstrom-Himes,Koichi Akashi,Daniel G. Tenen +11 more
TL;DR: Disruption of C/EBP alpha blocks the transition from the common myeloid to the granulocyte/monocyte progenitor but is not required beyond this stage for terminal granulocytes maturation, supporting the notion that disruption of EBP alpha cooperates with other events in the development of leukemia.
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Reversibility of acute B-cell leukaemia induced by BCR-ABL1.
TL;DR: It is demonstrated that BCR–ABL1 is required for both induction and maintenance of leukaemia.
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Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation.
Hiromi Iwasaki,Chamorro Somoza,Hirokazu Shigematsu,Estelle Duprez,Junko Iwasaki-Arai,Shinichi Mizuno,Yojiro Arinobu,Kristin Geary,Pu Zhang,Tajhal Dayaram,Maris Fenyus,Shannon Elf,Susan Chan,Philippe Kastner,Claudia S. Huettner,R Murray,Daniel G. Tenen,Koichi Akashi +17 more
TL;DR: HSCs express PU.1, and its constitutive expression is necessary for maintenance of the HSC pool in the bone marrow, which plays indispensable and distinct roles in hematopoietic development through supporting HSC self-renewal as well as commitment and maturation of myeloid and lymphoid lineages.
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Altered Microenvironmental Regulation of Leukemic and Normal Stem Cells in Chronic Myelogenous Leukemia
Bin Zhang,Yin Wei Ho,Qin Huang,Takahiro Maeda,Allen Lin,Sung-Uk Lee,Alan Hair,Tessa L. Holyoake,Claudia S. Huettner,Ravi Bhatia +9 more
TL;DR: CML LTHSC demonstrated reduced homing and retention in the bone marrow, related to decreased CXCL12 expression in CML BM, resulting from increased G-CSF production by leukemia cells.