Hui Deng

TL;DR: In this article, the authors show that breast TAMs abundantly produce CCL18, and its expression in blood or cancer stroma is associated with metastasis and reduced patient survival.

TL;DR: It was found that the downregulated miR-886-3p is closely correlated with the shorter survival of SCLC, and it was further discovered that loss of miR -886- 3p expression was mediated by DNA hypermethylation of its promoter in both cultured S CLC cells and tumor samples.

TL;DR: It is found that Thr567 hyperphosphorylation of the cytoskeletal protein ezrin was tightly correlated to an invasive phenotype of clinical hepatocellular carcinomas and to poor outcomes in tumor xenograft assays, and this findings suggest a strategy to reduce liver tumor metastasis by blocking Rho kinase-mediated phosphorylated eZrin.

TL;DR: The biochemical characterization demonstrated that ACAP4 has a phosphatidylinositol 4,5-bisphosphate-dependent GAP activity specific for ARF6, demonstrating the importance of ACAP2 in cell migration and shedding new light on the biological function of ARf6-mediated cell migration.