CCL18 from Tumor-Associated Macrophages Promotes Breast Cancer Metastasis via PITPNM3
Jingqi Chen,Jingqi Chen,Yandan Yao,Chang Gong,Fengyan Yu,Shicheng Su,Jianing Chen,Bodu Liu,Hui Deng,Fengsong Wang,Ling Lin,Herui Yao,Fengxi Su,Karen S. Anderson,Qiang Liu,Qiang Liu,Mark E. Ewen,Xuebiao Yao,Erwei Song +18 more
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TLDR
In this article, the authors show that breast TAMs abundantly produce CCL18, and its expression in blood or cancer stroma is associated with metastasis and reduced patient survival.About:
This article is published in Cancer Cell.The article was published on 2011-04-12 and is currently open access. It has received 495 citations till now. The article focuses on the topics: Metastasis & Cancer.read more
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Macrophage plasticity and polarization: in vivo veritas
Antonio Sica,Alberto Mantovani +1 more
TL;DR: The identification of mechanisms and molecules associated with macrophage plasticity and polarized activation provides a basis for Macrophage-centered diagnostic and therapeutic strategies.
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Macrophage biology in development, homeostasis and disease
TL;DR: This Review discusses how macrophage regulate normal physiology and development, and provides several examples of their pathophysiological roles in disease, and defines the ‘hallmarks’ of macrophages according to the states that they adopt during the performance of their various roles.
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Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms.
Eran Elinav,Roni Nowarski,Christoph A. Thaiss,Bo Hu,Chengcheng Jin,Richard A. Flavell,Richard A. Flavell +6 more
TL;DR: It is proposed that understanding this microbial influence will be crucial for targeted therapy in modern cancer treatment and the recently suggested role of commensal microorganisms in inflammation-induced cancer is discussed.
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Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy
TL;DR: This Review focuses on the main chemokines that are found in the human tumour microenvironment, and elaborate on their patterns of expression, their regulation and their roles in immune cell recruitment and in cancer and stromal cell biology.
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Immune cell promotion of metastasis
TL;DR: How tumour-infiltrating immune cells contribute to the metastatic cascade is described and potential therapeutic strategies to target these cells are discussed.
References
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Epithelial-Mesenchymal Transitions in Development and Disease
Jean Paul Thiery,Jean Paul Thiery,Hervé Acloque,Ruby Yun-Ju Huang,Ruby Yun-Ju Huang,M. Angela Nieto +5 more
TL;DR: The mesenchymal state is associated with the capacity of cells to migrate to distant organs and maintain stemness, allowing their subsequent differentiation into multiple cell types during development and the initiation of metastasis.
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Alternative activation of macrophages
TL;DR: The evidence in favour of alternative macrophage activation by the TH2-type cytokines interleukin-4 (IL-4) and IL-13 is assessed, and its limits and relevance to a range of immune and inflammatory conditions are defined.
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Tumour-educated macrophages promote tumour progression and metastasis
TL;DR: Macrophages are educated by the tumour microenvironment, so that they adopt a trophic role that facilitates angiogenesis, matrix breakdown and tumour-cell motility — all of which are elements of the metastatic process.
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Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis
TL;DR: Macrophages within the tumor microenvironment facilitate angiogenesis and extracellular-matrix breakdown and remodeling and promote tumor cell motility and are an important drug target for cancer therapy.
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Alternative Activation of Macrophages: An Immunologic Functional Perspective
TL;DR: The cellular sources of these cytokines, receptor signaling pathways, and induced markers and gene signatures are reviewed and the concept of macrophage activation in the context of the immune response is revisit.
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